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507 results about "Multiple disorders" patented technology
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Multiple personality disorder, or MPD, is a mental disturbance classified as one of the dissociative disorders in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).
Treatment of conditions through modulation of the autonomic nervous system
ActiveUS20050021092A1Increasing parasympathetic activity/sympathetic activity ratioElectrotherapyArtificial respirationNervous systemSubject matter
Methods are provided for treating a subject for a condition caused by an abnormality in the subject's autonomic nervous system. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is modulated to increase the parasympathetic activity / sympathetic activity ratio in a manner that is effective to treat the subject for the condition. Certain embodiments include modulating at least a portion of a subject's autonomic nervous system by inhibiting and / or increasing activity in at least a portion of the subject's autonomic nervous system. The subject methods find use in the treatment of a variety of different conditions, where such conditions include various disease conditions. Also provided are systems and kits for use in practicing the subject methods.
Owner:PALO ALTO INVESTORS
Treatment of conditions through modulation of the autonomic nervous system
ActiveUS20050240241A1Decreasing and increasing parasympathetic and activityIncreasing parasympathetic activity/sympathetic activity ratioSpinal electrodesAngle modulation detailsNervous systemAnatomy
Methods are provided for treating a subject for a condition by modulating at least a portion of the subject's autonomic nervous system. In accordance with certain embodiments of the subject methods, at least a portion of a subject's autonomic nervous system is electrically or pharmacologically modulated in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, where such conditions include various disease conditions. Also provided are systems and kits for use in practicing the subject methods.
Owner:PALO ALTO INVESTORS
Controlled vagal blockage therapy
A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
Owner:RESHAPE LIFESCIENCES INC
High frequency vagal blockage therapy
A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode at a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency in excess of 3,000 Hz for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus.
Owner:RESHAPE LIFESCIENCES INC
Nerve conduction block treatment
InactiveUS20040172086A1Function increaseAltered autonomic balanceSpinal electrodesImplantable neurostimulatorsDiseaseBlocking nerve
At least one of a plurality of disorders of a patient are treated where the disorders are associated with a gastrointestinal tract of a patient where the disorders are characterized at least in part by hyper-tonal vagal activity innervating at least one of a plurality of alimentary tract organs of the patient at an innervation site. The treatment includes applying a neural conduction block to a vagus nerve of the patient at a blocking site proximal to the innervation site. The neural conduction block is selected to at least partially block nerve impulses on the vagus nerve at the blocking site. A treatment apparatus has an electrically controllable neural conduction electrode adapted to be placed on a vagus nerve of a patient at a blocking site proximal to an innervation site.
Owner:RESHAPE LIFESCIENCES INC
Method, system and device for treating various disorders of the pelvic floor by electrical stimulation of the pudendal nerves and the sacral nerves at different sites
Described are implantable devices and methods for treating various disorders of the pelvic floor by means of electrical stimulation of the pudendal and sacral nerves, or portions thereof, and optional means for delivering drugs in association therewith. Two or more electrical stimulation regimes are applied on a continuous, alternating, intermittent or other basis to the sacral and pudendal nerves, and optionally one or more drugs are infused, injected or otherwise administered, to appropriate portions of a patient's pelvic floor and pudendal nerve and / or sacral nerve, or portions thereof, in an amount and manner effective to treat a number of disorders, including, but not limited to, urinary and / or fecal voiding dysfunctions such as constipation, incontinence disorders such as urge frequency and urinary retention disorders, sexual dysfunctions such as orgasmic and erectile dysfunction, pelvic pain, prostatitis, prostatalgia and prostatodynia.
Owner:MEDTRONIC INC
Treatment of conditions through pharmacological modulation of the autonomic nervous system
Methods are provided for treating a subject for a condition caused by an abnormality in the subject's autonomic nervous system. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is pharmacologically modulated with at least one beta-blocker in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, where such conditions include various disease conditions. Also provided are systems and kits for use in practicing the subject methods.
Owner:PALO ALTO INVESTORS
Rho kinase inhibitors
Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.
Owner:AERIE PHARMA
Selective androgen receptor modulators for treating diabetes
InactiveUS20070281906A1Reduce severityReduce morbidityBiocideSenses disorderSelective androgen receptor modulatorDiabetes retinopathy
This invention provides use of a SARM compound or a composition comprising the same in treating a variety of diseases or conditions in a subject, including, inter-alia, a diabetes disease, and / or disorder such as cardiovascular disease, atherosclerosis, cerebrovascular conditions, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy.
Owner:UNIV OF TENNESSEE RES FOUND
Substituted acylanilides and methods of use thereof
InactiveUS20080076828A1Reduce severityReduce morbidityAntibacterial agentsBiocideTherapy ObjectAniline Compounds
Owner:UNIV OF TENNESSEE RES FOUND
Method and apparatus for programming of autonomic neuromodulation for the treatment of obesity
InactiveUS20090187230A1Reduce or prevent conditionReducing and preventing symptomSensorsDigestive electrodesAfferent NeuronsDisease
The present invention teaches methods and apparatus for user control and operation of physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity. This includes programming of neuromodulatory signal for the modulation of autonomic neural and neuromuscular modulators, used to modulate tissues, including the afferent neurons of the sympathetic nervous system to induce satiety and efferent neurons to modulate metabolism.
Owner:DILORENZO DANIEL J
Polymorphisms in known genes associated with inflammatory autoimmune disease, methods of detection and uses thereof
The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to inflammatory and autoimmune disorders. Such polymorphisms can lead to a variety of disorders that are mediated / modulated by a variant inflammatory and autoimmune disorders associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid / protein sequence as well as methods of identifying and using these variants.
Owner:CELERA CORPORATION +1
Bulimia treatment
At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.
Owner:RESHAPE LIFESCIENCES INC
Amide derivatives as ABL modulators
InactiveUS20050148605A1Precise positioningLow toxicityBiocideOrganic chemistryDisease causeStereochemistry
The invention provides methods and compositions for treating conditions mediated by abl wherein derivatives of amide compounds are employed. The invention also provides methods of using the compounds and / or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
Owner:AMBIT BIOSCIENCES
Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity
InactiveUS7166575B2Improved pharmacokineticImproved pharmacodynamic resultPowder deliveryPeptide/protein ingredientsDiseaseHypodermoclysis
Pharmaceutical compositions and methods are described comprising at least one peptide YY compound and one or more intranasal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity. In one aspect, the intranasal delivery formulations and methods provide enhanced delivery of peptide YY to the blood plasma or central nervous system (CNS) tissue or fluid, for example, by yielding a peak concentration (Cmax) of the peptide YY in the blood plasma or CNS tissue or fluid of the subject that is 20% or greater compared to a peak concentration of the peptide YY in the blood plasma or CNS tissue or fluid of the subject following administration to the subject of a same concentration or dose of the peptide YY to the subject by subcutaneous injection.
Owner:MDRNA
Therapeutic procedures
InactiveUS20060217359A1Exacerbate and accelerate developmentPromote lipid uptakeAntibacterial agentsBiocideCholesterolCytotoxicity
As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cytotoxic cholesterol oxidation or ozonation products. The present application is directed to the products of cholesterol ozonation, binding entities directed against such products, and methods of using such binding entities and cytotoxins to treat a variety of diseases.
Owner:THE SCRIPPS RES INST
Imidazopyrazines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
Owner:MERCK SHARP & DOHME LLC
Selective androgen receptor modulators and methods of use thereof
InactiveUS20060035965A1Preventing and suppressing and inhibiting and reducing incidenceImprove muscle performanceBiocideAnimal repellantsSelective androgen receptor modulatorAndrogen Receptor Gene
Owner:UNIV OF TENNESSEE RES FOUND
Therapeutic methods using electromagnetic radiation
This invention provides methods for treating a variety of disorders using localized electromagnetic radiation directed at excitable tissues, including nerves, muscles and blood vessels. By controlling the wavelength, the wavelength bandpass, pulse duration, intensity, pulse frequency, and / or variations of those characteristics over time, and by selecting sites of exposure to electromagnetic radiation, improvements in the function of different tissues and organs can be provided. By monitoring physiological variables such as muscle tone and activity, temperature gradients, surface electromyography, blood flow and others, the practitioner can optimize a therapeutic regimen suited for the individual patient.
Owner:PHOTOMED TECH
Modified antigen-presenting cells
InactiveUS20050003484A1Efficient presentation of antigenEffective presentationSsRNA viruses negative-sensePeptide/protein ingredientsAntigenAntigen-presenting cell
The invention relates to antigen-presenting cells having specificity against a selected antigen and methods for making the cells. The invention also relates to a method of selecting efficient antigen-presenting cells using reporter fusion constructs. The highly efficient antigen-presenting cells of the invention will provide a therapeutic strategy of modulating immune responses for a variety of diseases.
Owner:DANA FARBER CANCER INST INC
Therapeutic methods using electromagnetic radiation
InactiveUS7150710B2High transparencyFunction increaseElectrotherapyPoint-like light sourceDiseaseElectromagnetic radiation
This invention provides methods for treating a variety of disorders using electromagnetic radiation directed at excitable tissues, including nerves, muscles and blood vessels. By controlling the wavelength, the wavelength bandpass, pulse duration, intensity, pulse frequency, and / or variations of those characteristics over time, and by selecting sites of exposure to electromagnetic radiation, improvements in the function of different tissues and organs can be provided. By monitoring physiological variables such as muscle tone and activity, temperature gradients, surface electromyography, blood flow and others, the practitioner can optimize a therapeutic regimen suited for the individual patient.
Owner:PHOTOMED TECH
Methods for diagnosing irritable bowel syndrome
InactiveUS20080085524A1Accurate classificationAccurate predictionAnalogue computers for chemical processesDisease diagnosisSAPS IIStatistical algorithm
The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with irritable bowel syndrome (IBS). In particular, the present invention is useful for classifying a sample from an individual as an IBS sample using a statistical algorithm and / or empirical data. The present invention is also useful for ruling out one or more diseases or disorders that present with IBS-like symptoms and ruling in IBS using a combination of statistical algorithms and / or empirical data. Thus, the present invention provides an accurate diagnostic prediction of IBS and prognostic information useful for guiding treatment decisions.
Owner:NESTEC SA
Novel imidazopyrazines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
Owner:MERCK SHARP & DOHME CORP
Apolipoprotein A-I agonist compounds
The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
Owner:DASSEUX JEAN LOUIS +5
Quinoline derivatives as pi3 kinase inhibitors
Invented is a method of inhibiting the activity / function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
Owner:GLAXO SMITHKLINE LLC
Selective androgen receptor modulators for treating muscle wasting
InactiveUS20070161608A1Improving lipid profileImproved profileBiocidePeptide/protein ingredientsSelective androgen receptor modulatorDisease
Owner:UNIV OF TENNESSEE RES FOUND
Novel Regimens for Treating Diseases and Disorders
Methods and materials are provided for induction-maintenance regimens of targeted anti-inflammatory therapies (TATs) for treatment of a variety of diseases and disorders. Preferred embodiments include administration of one or more TATs using an induction regimen comprising a lower dose per administration administered by a more invasive and / or more localized route, followed by administration of one or more TATS using a maintenance regimen, comprising a higher dose per administration administered by a less invasive and / or less localized route.
Owner:BIOASSETAB DEV CORP
Selective androgen receptor modulators and method of use thereof
InactiveUS20070173546A1Delaying the progression of prostate cancerDelay the progression of prostate cancerBiocideOrganic chemistrySelective androgen receptor modulatorAndrogen Receptor Gene
Owner:UNIV OF TENNESSEE RES FOUND
SCF Extract Containing Cardiac Glycoside
ActiveUS20080200401A1Good treatment effectDissolve completelyBiocideAntibiotics chemistryDiseaseOleandrin
Owner:PHOENIX BIOTECH INC +1
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
Owner:PHARMACOPEIA DRUG DISCOVERY +1
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