Anti-parasitic ivermectin transdermal solution used for livestock and preparation method thereof

Abstract

The invention relates to an anti-parasitic ivermectin transdermal solution used for livestock and a preparation method thereof. The anti-parasitic ivermectin transdermal solution comprises the following components respectively according to parts by volume: 5 to 15 parts of ethyl acetate, 20 to 30 parts of dimethyl sulfoxide, 2 to 6 parts of azone, 1 to 3 parts of isopropanol and 50 to 70 parts of propanediol; and the content of ivermectin is 0.3g to 1g in a solution of 100ml, and the finished product is prepared by the processes of dissolving, mixing, filtering and filling. The azone related in the prescription of the invention is a novel skin penetration enhancer, can increase the transdermal absorption of the skin to various medicines of different types, effectively avoids the pass effect of hepar, avoids peak and valley phenomena in the absorption process of the medicine, reduces the toxic or side effect caused by the correlative dosage in the medicine, prolongs the effective effect time, changes the administration area, effectively regulates the administration dosage and reduces differences among individuals. The invention has the characteristic of simple, convenient and fast use, and is more suitable for the anti-parasitic prevention and treatment of a pasturing area compared with other preparation forms.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to an anti-parasitic ivermectin transdermal solution for livestock and a preparation method thereof. Background technique [0002] Transdermal preparation is a new dosage form of transdermal administration, that is, the drug enters the whole body through the capillary of the skin and reaches the effective blood drug concentration through the blood circulation. Compared with transdermal preparations, it has the advantages of avoiding side effects caused by oral administration and gastrointestinal administration, such as hepatic effect and gastrointestinal inactivation, maintaining a constant blood concentration, and prolonging the effective time of action. [0003] The harm of parasites to livestock is mainly through the consumption of nutrients in livestock, causing mechanical damage, or lack of nutrition, which reduces the utilization rate of feed for livestock, result...

AI Technical Summary

Problems solved by technology

[0003] The harm of parasites to livestock is mainly through the consumption of nutrients in livestock, causing mechanical damage, or lack of nutrition, which reduces the utilization rate of feed for livestock, resulting in slow growth and reduced feed utilization.

At present, the most widely used dosage forms of antiparasitic drugs are injections, tablets, and pour-ons. Among them, pour-ons are mainly used to deworm in vitro, and there are very few drugs that really use the mechanism of transdermal absorption to deworm in vivo and in vitro.