119 results about "Anti parasitic" patented technology

Methods of treating, preventing and / or managing various protozoan parasitic disease and disorders are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone, or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with conventional anti-parasitic treatments which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

This application provides and discloses anti-parasitic, anti-pest or insecticidal nucleic acid molecules and their calmodulin target genes for the control of arthropod parasites and pests. This application further provides methods and compositions for the control and treatment of parasites and pests in Apis mellifera (honey bee) hives.

A composition prepared for treating animals suffering from parasites which parasites are known to be susceptible to at least one of the avermectins, milbemycins or salicylanilides, comprises for example ivermectin in an amount of from 0.1 to 10%(w / v), a solvent selected from the group consisting of glycerol formal, propylene glycol, polyethylene glycol and combinations thereof, and a salicylanilide such as closantel in a required dosage amount for the animal to be treated, typically about 2.5 mg / kg live weight of the animal to be treated, a polymeric species selected from the group consisting of polyvinylpyrrolidone and polyoxypropylene / polyoxyethylene block copolymers, the said polymeric species improving the bioavailability of closantel to the extend that blood plasma levels of the said compound greater than about 20 ppm over period of treatment are achievable.

A method for using ganoderma lucidum liquid fermentation liquor to prepare feed and feed additive containing ganoderma lucidum active ingredient, pertains to the field of biofermentation and feed. The invention includes steps of: a. centrifugally separating the ganoderma lucidum liquid fermentation liquor at 5000 per-minute to obtain the ganoderma lucidum fermentation supernatant and ganoderma lucidum residues; b. adopting a rear spraying process to mixing the ganoderma lucidum fermentation supernatant with the feed in a proportionality of adding 0.5-1.5 ml of the supernatant in the feed for preparing feed containing ganoderma lucidum active ingredient; c. performing a second fermentation to the ganoderma lucidum residues for preparing the feed additive containing ganoderma lucidum active ingredient. The invention fully use the ganoderma lucidum fermentation liquor, has no waste water and waste slag discharge, simple steps, low cost, and easy large-scale industrialization. Products are rich in Ganoderma lucidum polysaccharides and ganoderma lucidum acid; have a balance immune system, and antibacterial, antiviral, anti-parasitic, anti-tumor, anti-radiation and the like extensive physiology activities, thereby largely improving the immune disease resistance, maintaining the animal intestinal health, and further improving the production performance and market efficiency of animals.

The present invention provides methods for treating a coronavirus infection. For example, treatment may be effected by administering a neurotransmitter inhibitor, a signaling kinase inhibitor, an estrogen receptor inhibitor, a DNA metabolism inhibitor or an anti-parasitic agent. Also provided are methods for treating a coronavirus infection in which an anti-viral drug also is administered during any of the described methods.

The present invention provides an application of levo-orinidazole in preparation of medicine for resisting parasitization. The tests show that the levo-orinidazole is superior to dextro-orinidazole and racemic orinidazole in therapeutic action for curing parasitization (special for curing infection of trichomonas vaginalis and cecal amebic infection). Said invention also relates to the conventional dosage forms for clinical application, including oral preparation, venous administration preparation and vaginal medication preparation, etc.

The invention presented here establishes the use of a dialkyl ketone peroxide as a sterilizing, antiseptic, disinfecting and anti-parasitic agent, with no apparent toxicity nor ecotoxicity, and a very wide spectrum of activity in terms of the type of organisms on which it acts (bacteria, virus, fungi, spores, mycobacteria, protozoa, algae, prions, arachnids, mites, insects, etc.), and in terms of the type of applications in which it can be employed (human and animal therapy, hygiene, packing, medical and industrial instruments, sanitary surfaces and healthcare environments, premises, surfaces in general, industrial installations, refrigeration towers, sanitary hot water systems, purification of drinking water for human or animal consumption, etc.). Likewise, the current invention illustrates the use of a composition comprising such dialkyl ketone peroxides. Finally, the invention presented here provides a method of sterilisation, disinfection, asepsia or deparasitisation that involves the application of said composition.

The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.

The invention relates to a series of tenvermectin derivatives obtained by modification of tenvermectin A and / or tenvermectin B show in a following formula and a purpose of the tenvermectin derivatives on an anti-parasitic aspect. The control objects of the tenvermectin derivatives relate to parasites on agriculture and forestry crops, people, birds and beasts, and aquatic products. The derivatives have the advantages of good effect, low toxicity, and environment friendliness.

The present invention uses co-expression of protease inhibitors and protease sensitive therapeutic agents including phage and phagemids delivering peptides, therapeutic antibodies, DNA and RNA-based therapeutics that results in treating inflammation of a variety of disorders including psoriasis, atopic dermatitis and inflammatory bowel disease. The invention also provides bacteria that inhibit the growth of intestinal parasites such as worms, and deliver siRNA or miRNA that have specific anti-parasitic effects that results in the reduction or elimination of the parasite.

High load concentrate compositions comprising metaflumizone, a substantially water-insoluble anti-parasitic macrolide compound,such as moxidectin, an optional bridging agent, a surfactant, and a suitable carrier solvent are prepared. These compositions may be topically administered to animals, and are useful for preventing or treating ectoparasitic infestations in warm-blooded animals for prolonged periods of time. Additionally, they may be further diluted to provide other types of formulations useable for both topical and oral administration.

The invention relates to an anti-parasitic ivermectin transdermal solution used for livestock and a preparation method thereof. The anti-parasitic ivermectin transdermal solution comprises the following components respectively according to parts by volume: 5 to 15 parts of ethyl acetate, 20 to 30 parts of dimethyl sulfoxide, 2 to 6 parts of azone, 1 to 3 parts of isopropanol and 50 to 70 parts of propanediol; and the content of ivermectin is 0.3g to 1g in a solution of 100ml, and the finished product is prepared by the processes of dissolving, mixing, filtering and filling. The azone related in the prescription of the invention is a novel skin penetration enhancer, can increase the transdermal absorption of the skin to various medicines of different types, effectively avoids the pass effect of hepar, avoids peak and valley phenomena in the absorption process of the medicine, reduces the toxic or side effect caused by the correlative dosage in the medicine, prolongs the effective effect time, changes the administration area, effectively regulates the administration dosage and reduces differences among individuals. The invention has the characteristic of simple, convenient and fast use, and is more suitable for the anti-parasitic prevention and treatment of a pasturing area compared with other preparation forms.

Described herein is the synthesis, bioassay results and utility of new C-9 and C-10 substituted artemisinin derivatives with easily functionalizable groups attached to the artemisinin skeleton through carbon chain or heteroatoms. Described also is the demonstration of this class of compounds for their broad-spectrum anti-parasitic activity. Certain of these analogs possess noticeable cytotoxicity deliberately focused on treatment of cancerous diseases.

The invention provides a feed additive capable of improving the pig lean meat percentage and resisting the parasitic disease, which consists of kelp powder, nistose trihydrate, D-biotin, pine needle meal and the like. After the kelp powder is pre-processed, the kelp powder is combined with the nistose trihydrate, the D-biotin, phytase, glycine betaine and the like to perform obvious lethal actionon the endoparasite of the live pig and good curative effect on the pig parasitic disease; and pine needle meal and substances, such as L-arginine and L-tryptophan in a formula can be used for supplementing nutrition ingredients in the feed, promoting live pig growth and improving the lean meat percentage. The feed additive capable of improving the pig lean meat percentage and resisting the parasitic disease has good effect on various pig parasitic diseases, especially has a good curative effect on the lungworm and has the advantages of high effect taking speed, and no toxic or side effect, the egg decrement rate and the egg negative conversion ratio are obviously improved, the live pig can be promoted to grow and develop, and the lean meat percentage is improved.

The embodiments herein provide a powdered composition of natural substances for controlling deficiencies in polypeptide alpha and beta hemoglobin chains and a diet plan for treating thalassemia patient. The composition comprises passargad powder, pars powder, purgative material, fumigation material, snuffing material, vinegar syrup and parsomash powder. The passargad powder is a stomach tonic and acts as anti-parasitic, anti-diarrheal, anti-dysentery, anti-bloating and anti-heartburn agents. The pars powder comprises sprouted grains for providing nutrition to cells. The purgative material is body purifier or detoxification agent and helps in motion and bowl movement. The vapor / fumigation material softens and reduces stickiness of sputum and removes sputum. The snuff helps in sneezing and removal of sputum. The vinegar syrup breaks down fat and removes toxins. The parsomash is an detoxification agent. The composition and dietary plan eliminates the need of bone marrow transplant, blood transfusion and defroxamin in thalassemia patients.

The invention is a user friendly, multi-purpose ointment whose simple basic formula is a combination of karaya gum powder and a vehicle for dispersing, such as petrolatum. It can be designed to treat a variety of skin problems by adding some non-essential ingredients such as Vitamin A&D Ointment, Vitamin E cream or Lotion at the discretion of the user, in addition to various pharmaceuticals based on the cause of the problem such as an antibacterial, an antifungal, an anti-inflammatory agent, an antiviral, an anti-parasitic, or an enzymatic agent at the discretion of the health care provider or user.

The present invention relates to a pharmaceutical composition. The pharmaceutical composition comprises: at least one first therapeutically-active substance which is selected from carveol, thymol, eugenol, borneol, carvacrol and the isomers, derivatives and mixtures thereof; and at least one second therapeutically-active substance which is selected from an antiviral agent, an antitumour agent and an antiparasitic agent.

The invention relates to a nutritional feed for eel. The nutritional feed is characterized by comprising the following components by weight parts: 45-50 parts of fish meal, 5-15 parts of shrimp meal, 5-20 parts of soybean meal, 1-15 parts of algae, 0.1-0.5 parts of an adhesive, 1-4 parts of a disease and insect resistant component and .01-1 part of a composite nutritional component. A preparation method of the feed comprises mixing the raw materials according to ratio, crushing the mixed raw materials, with moisture being less than 15 % after the crushing, sieving by using a sieve, uniformly stirring, drying and packaging to obtain finish product. The nutritional feed for the eel provided by the invention is scientific and reasonable, economic and suitable, can timely supplement nutrition according to growth characteristics of the eels, promote growth and effectively resist parasitic diseases, and thus is suitable for culturing of a whole eel growth period.

The invention belongs to the technical field of breeding, and particularly relates to an ecological breeding method for beef cattle. The method comprises the specific steps of cowhouse building, wherein a cowhouse is built by the adoption of a tile structure and a concrete floor; pasture management, wherein a mountainous area in which the mean annual sunshine duration is 8-10 hours per day serves as a pasture, Albizzia julibrissin, Mimosa pudica, orchard grass, sweet elephant grass, barley and clover are planted to serve as a movement area of the beef cattle, and construction is conducted; scatter breeding management, wherein the beef cattle is driven to the pasture for scatter breeding at 8:00-11:30 and 14:00-15:30 every day; breeding management, wherein while scatter breeding is conducted, after scatter breeding and homing, the beef cattle is fed with daily ration every day; disease prevention, wherein the cowhouse is disinfected once every 15 days, preventive vaccine is injected once every two months, and the beef cattle are fed with an anti-parasitic drug; faeces of the beef cattle are fermented, and a fertilizer is prepared to be applied to soil of the pasture. In the method, natural resources are completely used, and no chemical synthetic matter is contained. By means of the method, the production performance of the beef cattle is improved.

The functions of IFNgamma-induced GTPases of the IGTP-family as strong anti-infective agents, and more particularly a strong anti-parasite and / or anti-bacterial agents, are disclosed. These molecules (in both protein and nucleic acid forms) are effective to modify anti-microbial e.g., anti-bacterial and / or anti-parasitic) immune responses in a subject, to prevent or inhibit replication or infectivity of microbe, to treat microbial diseases, and to detect susceptibility of a subject to microbial infection. This invention also provides kits and compounds useful in such methods. Also provided are transgenic non-human animals in which IGTP-family member gene expression has been altered, and the use of such animals to screen for anti-microbial agents.

The present invention provides methods for treating a coronavirus infection. For example, treatment may be effected by administering a neurotransmitter inhibitor, a signaling kinase inhibitor, an estrogen receptor inhibitor, a DNA metabolism inhibitor or an anti-parasitic agent. Also provided are methods for treating a coronavirus infection in which an anti-viral drug also is administered during any of the described methods.

The invention belongs to the technical field of veterinary anti-parasitic medicaments, particularly relates to a compound ivermectin injection and a preparation method thereof, and aims to provide an injection for treating parasitic infection of livestock, expanding an anti-parasitic spectrum and enhancing a therapeutic effect and a preparation method thereof. Every 100ml of compound ivermectin injection comprises 0.5-2g of ivermectin, 2.5-10g of albendazole sulfoxide, 5-15ml of polyethylene glycol 400 (PEG400), 1-10ml of acetic ether, 0.5-2ml of benzyl alcohol, 0.05-0.2ml of alpha-thioglycerol, 10-30ml of dimethyl sulfoxide and the balance of propylene glycol. In the injection, the ivermectin and the albendazole sulfoxide are used as anti-parasitic main components; the injection has double complementary advantages; the anti-parasitic spectrum is expanded; the drug resistance probability of parasites can be effectively reduced; and the sensitivity of the parasites is improved. The invention brings a completely new situation for safely, effectively and conveniently preventing and treating parasitic diseases in animal husbandry and aquaculture of China.

The invention discloses a method for preparing a Sarah rhzomorph nano emulsion medicine composition and a formula. The preparation is an O / W (oil-in-water type) nano emulsion system which consists of ethylis oleas, Tween-80, n-butyl alcohol, ultrapure water and Sarah rhzomorph; the nano emulsion system has high medicine loading quantity (more than 11 percent); the medicine can be diluted by injection water or normal saline according to any rate in accordance with the clinical practical requirements; and the medicine is stably placed, so that the bioavailability of the medicine is greatly improved, the high dosage of the traditional transdermal medicine is effectively overcome; the insecticidal insect repellent function on the Sarah rhzomorph is greatly improved; and the clinical dosage of the Sarah rhzomorph is reduced to an extreme limit. The content of 1 percent of the preparation auxiliary materials (ethylis oleas, Tween-80, n-butyl alcohol and the like) is reduced to 4.1 percent on year-on-year basis; the content of 1 millesimal of the preparation auxiliary materials is reduced to 4.1 millesimal; the external properties are the same as those of true solution; compared with the transdermal preparation, the clinical dosage of the Sarah rhzomorph is reduced from 6mg / kg to 0.2mg / kg, and the curative effect is same; and therefore, at the present of deficiency of raw material medicines, the Sarah rhzomorph nano emulsion medicine is successfully researched, so that the dosage quantity is reduced, the dosage cost of a livestock master is reduced, the damage of the medicines to environment and public hygiene is greatly reduced; and in addition, according to an acute toxicity test and clinical pharmacodynamic test on mice, the nano emulsion medicine is free of toxic and side effects, so that the nano-level anti-parasitic medicine is safe, reliable and effective.

The invention discloses an anti-parasitical medicine in situ setting slow release injection and a preparation method thereof. The injection comprises the following components in ratio: 1-80g of an anti-parasitic disease medicine, 1-100g of a biodegradable high polymer material, 2-300mL of a dispersion medium and 0-50g of a solubilizer, wherein the content of the anti-parasitic disease medicine is1-800mg / mL. The injection can maintain long-term control effect when being medicated to a medicated object only once, the medicated object is protected from being infected by pathogens, propagation ofparasitic diseases can be economically and effectively controlled, material safety is high, prescription of a commercially available anti-parasitic disease medicine is simplified, compliance of the medicated object is improved, and control cost is reduced. Meanwhile, subcutaneous injection slow release injection is prepared by innovatively using a molluscicide, namely niclosamide, of the WHO, andthe effect of preventing schistosoma japonicum infection is achieved. The anti-parasitical medicine in situ setting slow release injection is simple in the preparation method, has good stability andis easy to use and popularize.

The invention relates to a method for preparing an economical and efficient veterinary long-acting injection by adding a proper sustained-release material in an oil-based medium to improve the traditional oil-based injection. The method comprises the following specific steps: dissolving sucrose acetate isobutyrate and dimethicone with viscosity less than 20cs in isopropyl myristate or dissolving the dimethicone with viscosity less than 20cs and aluminum stearate in the isopropyl myristate to prepare the veterinary long-acting injection containing antibacterial agents or containing anti-parasitic drugs or containing non-steroidal anti-inflammatory drugs. The preparation is good in sustained release effect, stable in character, good in tissue compatibility and easy to prepare.

The invention relates to a high-efficiency high-stereoselectivity semisynthesis method of harringtonine and allied alkaloids, which uses optical pure cephalotaxin serving as a raw material to perform reactive synthesis with substituted silicon ketene in Lewis acid catalysis. The structural general formula of the compound is shown as (A), wherein the meaning of each group is shown as the specification. The method has the advantages of high chemical yield and diastereoselectivity of key reactions, convenient operation, short synthesis steps and the like. The method is a universal method for synthesizing the optical pure compound with the structural general formula shown as (A), and is suitable for massive preparation. The compound is widely applied to anti-tumor (malignant and non-malignant tumors), anti-parasitic, antifungal and antimicrobial chemotherapy medicaments.

The invention relates to a veterinary anti-parasitic injection containing carnauba wax. The preparation is mainly prepared from anti-parasitic medicine, the carnauba wax and an oily medium, wherein the anti-parasitic medicine is avermectins, praziquantel and oxfendazole; the oily medium is vegetable oil, ethyl oleate or benzyl benzoate, and more than one of the vegetable oil, ethyl oleate or benzyl benzoate can be combined to use. Glycerol mono-oleate can be added in the preparation, the carnauba wax and the glycerol mono-oleate are compositely applied, and the slow-release effect of the preparation is better. The selected preparation is prepared from 36-80 g of abamectin anti-parasitic medicine, 10-70 g of the carnauba wax, 80-120 g of the glycerol mono-oleate, 0.1-0.3 g of an antioxidant, 10-20 g of benzyl alcohol and the balance of the oily medium (per 1000ml).