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Sarah rhzomorph nano emulsion medicine composition and preparation method thereof

A technology of selamectin and nanoemulsion, which is applied in the direction of drug combination, pharmaceutical formula, anti-infective drugs, etc., can solve the problems of poor water solubility of selamectin, achieve reduced clinical dosage, good thermodynamic stability, and improve insecticidal The effect of insect repellent

Inactive Publication Date: 2013-03-06
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention makes selamectin into nanoemulsion, which greatly enhances the efficacy of selamectin, and also solves the shortcoming of selamectin's poor water solubility

Method used

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  • Sarah rhzomorph nano emulsion medicine composition and preparation method thereof
  • Sarah rhzomorph nano emulsion medicine composition and preparation method thereof
  • Sarah rhzomorph nano emulsion medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1) Weigh 6g of ethyl oleate, 22g of Tween-80, 11.5g of n-butanol, 3g of selamectin, and 57.5g of ultrapure water for use;

[0044] 2) At room temperature, place the ethyl oleate, Tween-80, n-butanol, and selamectin of the above weight on a constant temperature magnetic stirrer at 200-400rpm and stir until the drug is dissolved in the system middle.

[0045] 3) Slowly add ultrapure water to the mixture, and stir while adding; at the beginning, the viscosity of the system is small, and as the water volume increases to 16ml, the system gradually becomes viscous, and at this time the system may appear liquid crystal phase or W / O (Water-in-oil type) nano-emulsion, continue to drop and stir continuously, when the water volume reaches 32ml, the system will suddenly become clear and thin, and the O / W type nano-emulsion will be produced at this time, add ultra-pure water to 57.5ml, the fluidity of the system is good, and it is prepared into a clear and transparent O / W nanoemuls...

Embodiment 2

[0047] 1) Weigh 1.6g of ethyl oleate, 13.2g of Tween-80, 9.7g of n-butanol, 2g of selamectin, and 73.5g of ultrapure water for each drug component.

[0048] 2) At room temperature, place the ethyl oleate, Tween-80, n-butanol, ultrapure water, and selamectin on a constant temperature magnetic stirrer at 200 to 400 rpm to stir and mix until The drug is dissolved in the above system.

[0049] 3) Slowly add ultra-pure water to the mixture, and stir while adding; at the beginning, the viscosity of the system is small, and as the amount of water increases, the system gradually becomes viscous. At this time, the system may appear liquid crystal phase or W / O (oil-in-oil Water-type) nano-emulsion, continue to drop and stir continuously, when the water volume reaches 50ml, the system will suddenly become clear and thin, at this time, the O / W-type nano-emulsion is produced, add ultra-pure water to 73.5ml, The fluidity of the system is good, and it is prepared into a clear and transparen...

Embodiment 3

[0051] 1) Weigh 5.1 g of ethyl oleate, 27 g of Tween-80, 13.2 g of n-butanol, 43.7 g of ultrapure water, and 11 g of selamectin for each drug component.

[0052] 2) At room temperature, place the ethyl oleate, Tween-80, n-butanol, ultrapure water, and selamectin on a constant temperature magnetic stirrer at 200 to 400 rpm to stir and mix until The drug is dissolved in the above system.

[0053] 3) Slowly add ultrapure water to the mixture, and stir while adding; at the beginning, the viscosity of the system is small, and as the amount of water increases, the system gradually becomes viscous. At this time, the system may appear liquid crystal phase or W / O (oil Water-containing type) nanoemulsion, continue to drop and stir continuously, when the water volume reaches 32ml, the system will suddenly become clear and thin, and the O / W type nanoemulsion will be produced at this time, add ultra-pure water to 49.7ml , the fluidity of the system is good, and it is prepared into a clear...

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Abstract

The invention discloses a method for preparing a Sarah rhzomorph nano emulsion medicine composition and a formula. The preparation is an O / W (oil-in-water type) nano emulsion system which consists of ethylis oleas, Tween-80, n-butyl alcohol, ultrapure water and Sarah rhzomorph; the nano emulsion system has high medicine loading quantity (more than 11 percent); the medicine can be diluted by injection water or normal saline according to any rate in accordance with the clinical practical requirements; and the medicine is stably placed, so that the bioavailability of the medicine is greatly improved, the high dosage of the traditional transdermal medicine is effectively overcome; the insecticidal insect repellent function on the Sarah rhzomorph is greatly improved; and the clinical dosage of the Sarah rhzomorph is reduced to an extreme limit. The content of 1 percent of the preparation auxiliary materials (ethylis oleas, Tween-80, n-butyl alcohol and the like) is reduced to 4.1 percent on year-on-year basis; the content of 1 millesimal of the preparation auxiliary materials is reduced to 4.1 millesimal; the external properties are the same as those of true solution; compared with the transdermal preparation, the clinical dosage of the Sarah rhzomorph is reduced from 6mg / kg to 0.2mg / kg, and the curative effect is same; and therefore, at the present of deficiency of raw material medicines, the Sarah rhzomorph nano emulsion medicine is successfully researched, so that the dosage quantity is reduced, the dosage cost of a livestock master is reduced, the damage of the medicines to environment and public hygiene is greatly reduced; and in addition, according to an acute toxicity test and clinical pharmacodynamic test on mice, the nano emulsion medicine is free of toxic and side effects, so that the nano-level anti-parasitic medicine is safe, reliable and effective.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to an anti-parasitic pharmaceutical preparation for efficiently expelling various arthropod insects such as nematodes in livestock and poultry and external lice, fleas, and mites, and specifically refers to a selamectin nanoemulsion medicine and a preparation method thereof . Background technique [0002] Macrolide anti-parasitic drugs are anti-parasitic drugs with dual functions of anti-parasites and ecto-parasites, mainly including two types, namely avermectins and milbemycins, avermectins Drugs include Avermectin, Ivermectin, Doramectin, Eprinomectin, Selamctin, Milbemycin mainly There are Milbemycins, Moxidectin, and Milbemycin Oxime. Among them, ivermectin, doramectin, apnomycin, selamectin and moxidectin are commonly used clinical drugs. Macrolides, which have a complex macrolide ring, are all produced by fermentation of Streptomyces in soil, but each drug also has its own ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/7048A61P33/10A61P33/14
Inventor 张继瑜周绪正李冰李剑勇李金善魏小娟牛建荣杨亚军刘希望汪芳
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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