165 results about "Niclosamide" patented technology

This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and / or niclosamide analogues when orally administered in conjunction with a peptide pharmaceutical (e.g., a class A amphipathic helical peptide as described herein) significantly increases the bioavailability of that peptide. Methods of peptide delivery using such “delivery agents” and pharmaceutical formulations are provided.

The invention provides a worm-disease-resisting compound niclosamide tablet for beasts and birds and a preparation method thereof. The worm-disease-resisting compound niclosamide tablet for beasts and birds respectively includes the following components by mass: 0.5-2 parts of tiandixiang (a flavoring agent), 0.5-2 parts of aspartame, 8-12 parts of starch, 20-40 parts of oral glucose or cane sugar, 0.5-2 parts of mannitol, 0.3-0.8 part of magnesium stearate, 40-60 parts of niclosamide and 2.5-5 parts of levamisole hydrochloride. The preparation method includes performing 17-mesh palletizing through a starch inside-outside addition and wet process mode, drying for 2-3 hours at the temperature of 65-75 DEG C, performing 17-mesh granulating straightening, additionally mixing the tiandixiang, the aspartame and the magnesium stearate, performing tabletting and the like to obtain the finished products. The worm-disease-resisting compound niclosamide tablet is bright and clean in appearance, fast in disintegration, good in desinsectization effect after being taken orally, simple in process, good in taste and suitable for industrial production, and various indexes of the tablet are optimized.

The invention discloses an application of niclosamide or pharmaceutically-acceptable salts thereof in preparing anti-tumor drugs, which provides a candidate drug for tumor patients and may further improve the therapeutic effect and the prognosis to patients. The effectiveness of niclosamide or pharmaceutically-acceptable salts thereof on various tumor cells indicates that the composition may be used for treating various cancers such as cerebroma, genitourinary tumor, lymphatic system, stomach cancer, cancer of larynx, nasopharyngeal cancer, skin cancer, bone cancer, leukaemia, leukaemia, breast cancer, histiocytic lymphoma, non-small-cell lung cancer, small-cell lung cancer, lung adenocarcinoma, epidermoid cancer, pancreatic cancer, prostatic cancer, liver cancer and epithelial cell cancer.

The invention relates to a method of treating a viral infection caused by or associated with SARS-CoV-2 in a subject, the method comprising administering to the subject by inhalation intraorally and / or intranasally a therapeutically effective amount of a formulation comprising niclosamide, or a pharmaceutically acceptable salt thereof, and a cyclodextrin.

The present invention relates to one kind of niclosamide ethanolamine salt powder preparation and its preparation process, and belongs to the field of pesticide producing technology. Niclosamide ethanolamine salt is used as molluscacide for controlling and eliminating schistosomiasis. Niclosamide ethanolamine salt, sodium lignosulfonate and dodecyl sodium bensosulfonate are first mixed and crushed; the mixing powder is then mixed with partial stuffing of 4 times to form the intermediate mixture; and the intermediate mixture is finally with other stuffing and the mixture is crushed to obtain the finished product. The present invention has high effect of killing watersnail, including watersnail and its egg.

The present invention relates to niclosamide colloidal suspension and its preparation process. The niclosamide colloidal suspension is ropy fluid comprising solid niclosamide, water and several assistants. It is used for killing rice field snail, Fushou snail and schistosome. It has high pesticidal effect and is superior to oil emulsion, wettable powder and other conventional forms.

The invention discloses niclosamide membrane spreading oil and a preparation method and applications thereof. The niclosamide membrane spreading oil comprises the following components in mass percent: 1-10% of niclosamide, 5-25% of solvent, 1-20% of nonionic surface active agent, 1-10% of membrane forming assistant agent and the rest of oleic acid ester. The product of the invention is a new-typepesticide formulation which is dropwise applied on the water surface in ultralow volume, is not emulsified and is not dissolved; liquid medicine rapidly spreads into a membranoid substance when touching the water surface; a membrane agent passes through a series of physical processes, such as phase changing and the like, after spreading; and the medicine floats on the water surface in the particles, and the grain diameter of which is less than 0.1 micron. The niclosamide membrane spreading oil has the characteristics of high efficiency, environmental protection, low toxicity, broad spectrum, safety, very simple and convenient use, energy saving and labor saving, no needing of any apparatus, capability of being directly dropwise applied on the surface of water, and low comprehensive cost and the like.

The invention relates to niclosamide and derivates thereof, which effectively inhibit transcription of the S100A4 gene, resulting in inhibition and / or reduction of S100A4-induced cell motility, invasiveness, metastasis and proliferation of human cancer cells.

The invention provides niclosamide ethanolamine salt wettable powder as well as a preparation method and application thereof. The wettable powder is prepared from niclosamide ethanolamine salt, a dispersing and wetting agent, a suspension aid and an anti-caking agent, wherein the dispersing and wetting agent is a compound mixture of fatty alcohol-polyoxyethylene ether and a non-ionic hydroxyl polyethylene oxide block copolymer, and the use amount of the dispersing and wetting agent accounts for 8-15% of the total weight of the raw materials. By using the compound mixture of the fatty alcohol-polyoxyethylene ether and the non-ionic hydroxyl polyethylene oxide block copolymer as the dispersing and wetting agent, a unique steric hindrance effect is provided in the system, so that the stability of the system is effectively kept and the problems of slow wetting, color change and flocculation are solved; the wettable powder is short in wetting time, uniform in dispersion effect, relatively small in particle size distribution, capable of rapidly reaching a target site, free from flocculation for a long time and free from particle aggregation, so that the wettable powder has long-lasting efficacy and applicable to hard water. The wettable powder disclosed by the invention is applicable to the preparation of molluscicidal products and is good in molluscicidal effect.

The invention discloses a snail control insecticide of compound niclosamide ethanolamine salt suspending agent which comprises the constituents (by weight portion) of niclosamide ethanolamine salt 1-50 parts, methaldehyde 0.01-5 parts, dispersing agent 1-20 parts, wetting agent 0.5-20 parts, and thickening agent 0.05-10 parts, and balancing water. The invention also discloses the process for preparing the suspending agent.

The invention discloses a pretreatment kit and method for detecting niclosamide in aquatic products. The kit comprises a kit body and reagent bottles which are respectively put in six empty areas of a, b, c, d, e and f in the kit body. The method comprises the following steps: A. putting a sample into a centrifugal tube, adding a first reagent, and oscillating; B. adding a second reagent, oscillating, centrifuging, and transferring supernate; C. adding the first reagent into the original centrifugal tube, oscillating, after centrifugation, taking the supernate out and mixing the supernate with the last supernate; D. metering the mixed liquid with a certain volume, after shaking uniformly, taking certain volume of liquid and putting into the centrifugal tube, and blow-drying with nitrogen; and E. dissolving residues with the solution of a third reagent, adding a fourth reagent, oscillating, centrifuging, taking the clear liquid and filtering, and carrying out HPLC-MS / MS(high performance liquid chromatography-mass spectrometry / mass spectrometry) measurement. The detecting method is simple, fast and accurate, high in sensitivity and low in cost, and is easy to popularize. The pretreatment kit is suitable for treatment of eatable samples of large amount of fresh and alive and ice aquatic products, and the pretreatment efficiency of the samples is greatly improved.

The present invention relates to a suspending agent formed from niclosamide as chemical active substance and several auxiliary materials and its preparation method. Its preparation method includes: using niclosamide as raw material medicine, adding moistening agent, dispersing and suspending aid, tack-producing agent, antifreezing agent, preservative, defoaming agent and water, uniformly mixing them, pulverizing by means of high shearing emulsifying machine in a barrel, grinding for once or at twice, and quality test and packaging so as to obtain the invented niclosamide pesticide spirillicide suspending agent.

The invention discloses niclosamide phosphate ester, a pharmaceutically acceptable salt thereof, and application of the niclosamide phosphate ester serving as a soluble pro-drug of niclosamide in preparing correlative medicaments. The niclosamide phosphate ester has a general formula of I or II. The niclosamide phosphate ester and the pharmaceutically acceptable salt thereof have good water solubility, and can be used for producing niclosamide parent drugs through metabolism. Thus, the niclosamide phosphate ester and the pharmaceutically acceptable salt can be used as water-soluble oncomelania-killing medicaments (for treating schistosomiasis), water-soluble human and livestock tapeworm expelling medicaments, and novel antineoplastic medicaments.

The invention belongs to the technical field of snail control and particularly discloses an efficient snail controlling suspending agent and a preparation method thereof. The suspending agent takes metaldehyde and / or niclosamide ethanolamine as active ingredients and a natural surfactant as an emulsifying agent, and has an efficient snail controlling effect. According to the invention, the pesticide effect of the snail controlling chemical can be enhanced and the snail controlling agent can keep a high pesticide effect in a wide environment range.

The invention discloses a luokuwei-containing compound gastropod-killing composition, the luokuwei-containing compound gastropod-killing composition comprises an active component A and an active component B, the active component A is selected from luokuwei, the active component B is selected from any one of the following compounds: metaldehyde, niclosamide and niclosamide ethanolamine, and the weight ratio of the active component A to the active component B is 1: 60-80:1. The luokuwei-containing compound gastropod-killing composition has a synergistic effect on a plurality of harmful gastropod damaging agricultural production, can reduce the pesticide use amount, reduce pesticide residues on crops, and reduce environmental pollution, is safe to human and livestock, and has good environment compatibility, and diseases have low tendency to produce resistance to the composition.

The present invention belongs to the field of biological pesticide, and is especially one kind of high efficiency and low toxicity molluscacide containing ginkgolic acid. The present invention adopts ginkgolic acid as main component, and niclosamide, copper ion and supplementary material to compound composite molluscacide for killing water snail as the unique intermediate host of blood flukes and preventing propagation of schistosomiasis. The test shows that the molluscacide has fast water snail killing effect, no damage to human body and no obvious toxicity on fresh water fish. The molluscacide may be prepared into concentrated liquid preparation or solid preparation for easy production, storing, transportation and use.

The invention relates to niclosamide ethanolamine salt nano suspending agent for killing oncomelania and its preparation method, belongs to oncomelania-killing drug and insoluble drug nano preparation technology field. The method comprises steps of adding dimethyl sulphoxide to stablizer 1%-10% in mass content and niclosamide ethanolamine salt 5%-25% in mass content and mixing ,confecting solution, obtaining niclosamide ethanolamine salt nano suspending agent stock solution, adding it to aqueous solution when stirring niclosamide ethanolamine salt content being 0.01%-1%, niclosamide ethanolamine salt grain size being 50nm-1 mum, obtaining niclosamide ethanolamine salt nano suspending agent. The inventive method can make water-insoluble niclosamide ethanolamine salt disperse well in waterbody. The solution can be used while being prepared. The inventive niclosamide ethanolamine salt nano suspending agent is simply prepared, and promote bioavailability while meet the need of killing snail and reduce the toxicity to fish.

The invention discloses an anti-parasitical medicine in situ setting slow release injection and a preparation method thereof. The injection comprises the following components in ratio: 1-80g of an anti-parasitic disease medicine, 1-100g of a biodegradable high polymer material, 2-300mL of a dispersion medium and 0-50g of a solubilizer, wherein the content of the anti-parasitic disease medicine is1-800mg / mL. The injection can maintain long-term control effect when being medicated to a medicated object only once, the medicated object is protected from being infected by pathogens, propagation ofparasitic diseases can be economically and effectively controlled, material safety is high, prescription of a commercially available anti-parasitic disease medicine is simplified, compliance of the medicated object is improved, and control cost is reduced. Meanwhile, subcutaneous injection slow release injection is prepared by innovatively using a molluscicide, namely niclosamide, of the WHO, andthe effect of preventing schistosoma japonicum infection is achieved. The anti-parasitical medicine in situ setting slow release injection is simple in the preparation method, has good stability andis easy to use and popularize.

The present invention relates to novel therapeutic uses of niclosamide for the treatment of cancer. In particular, a combination of niclosamide or one of its derivatives with an alkylating agent is provided for the treatment of solid tumors. Moreover, niclosamide or one of its derivatives can be used for the treatment of solid tumors characterized by underexpression of NFKBIA. Finally, the invention relates to diagnostic methods for determining whether treatment with niclosamide alone or in combination with an alkylating agent is suitable for a cancer patient.

The invention discloses application of niclosamide in treatment or prevention of melanoma, and relates to the field of melanoma treatment or prevention drugs. A research of the invention finds that the niclosamide has an obvious anti-tumor effect; the niclosamide can effectively inhibit multiplication of the melanoma; the niclosamide can inhibit migration and invasion of the melanoma; the niclosamide can promote apoptosis of the melanoma; and the research further finds that the niclosamide agent can improve the activity of tyrosinase in melanoma cells and promote secretion of melanin, and indicates that the niclosamide agent can promote terminal differentiation of the melanoma cells. The research of the invention indicates that the niclosamide has a wide application value in the field of treatment or prevention of the melanoma and the like and has a prospect of serving as a melanoma resisting drug.

The invention provides a niclosamide nano suspending agent as a medicament for controlling oncomelania hupensis and its preparing process, wherein the basic constituents include (by weight percent) niclosamide 15-25%, water-soluble high polymer 0.05-0.5%, surface active agent 3-15%, defoaming agent 1-10%, and balancing water as dispersion medium.

The invention discloses a pharmaceutical composition containing an inorganic arsenic compound and application of the pharmaceutical composition. The pharmaceutical composition contains the inorganic arsenic compound and Niclosamide and is used for preparing a cancer treatment medicine. Niclosamide has the molecular formula of C13H8Cl2N2O4 and the CAS number of 50-65-7. The pharmaceutical composition has a stronger cancer cell killing function than that of independent use of the inorganic arsenic compound or Niclosamide. The therapeutic dose of the inorganic arsenic compound is reduced, the cancer inhibition effect is enhanced, and the systematic poisonousness of the inorganic arsenic compound is effectively reduced.

The invention discloses a pesticide composition with emamectin benzoate and niclosamide ethanolamine, and belongs to the field of chemical prevention. The pesticide composition comprises the niclosamide ethanolamine, the emamectin benzoate and auxiliaries. The niclosamide ethanolamine and the emamectin benzoate are effective ingredients. The pesticide composition has the advantages that excellent synergistic effects can be realized by the pesticide composition for preventing soft injurious insects and oncomelania in particular; a synergistic ratio of the pesticide composition to the oncomelania during indoor bioassay is 20:1-1:20; the obvious synergistic effects and good prevention effects can be realized by the pesticide composition, the pesticide composition is low in dosage and safe for environments and target biomasses, can be used for various insect pests and also can be used for treating other soft insect pests (such as pomacea canaliculata and slug), excellent effects for relieving pesticide resistance of the oncomelania can be realized.

The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosamide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by Gram-positive bacteria such as Staphylococcus, in particular Staphylococcus aureus, and Streptococcus, in particular Streptococcus pyogenes. Gram positive bacteria treated with the halogenated salicylanilides exhibit a very low frequency of appearance of resistant mutants compared to commonly used topical antibiotics.

The invention relates to a medicament used for killing oncomelania and schistosoma japonicum cercaria, in particular to an environmental-protection typed niclosamide slow releasing block and a preparation method thereof. The best proportioning of the slow releasing block of the invention according to the weight portions is 50 portions of niclosamide ethanolamine salt wettable powder, 30 portions of sawdust, 20 portions of perlite and 3 portions of polyvinyl alcohol for the upper floating type and is 50 portions of niclosamide ethanolamine salt wettable powder, 20 portions of sawdust, 30 portions of red soil and 3 portions of polyvinyl alcohol. The invention uses the niclosamide recommended by WHO as the main medicament; the adopted carrier material is sawdust which has low price and causes no environmental pollution; more than 6,000m<2> can be released in the operation of two persons each day, thus saving the niclosamide by 50% and the cost by 40%.

The invention relates to a novel niclosamide ethanolamine salt suspending agent and method for making same, which is in the form of homogeneous flow viscous agent comprising solid original liquid medicine, water and multiple auxiliary agents for eradication of rice field snail, spiro and schistosomiasis prevention and cure. The suspending agent according to the invention has satisfactory effect in killing mollusk, and it overcomes the drawbacks of the conventional wettable powders.

The invention belongs to the field of fish breeding, and particularly relates to a method for preventing roes from being attacked by saprolegniasis.The method for preventing roes from being attacked by saprolegniasis includes the operation steps that a pond is filled with water, niclosamide is put into a water body in the pond, and the input amount of niclosamide is controlled in the mode that 2-3 kg niclosamide is put in per meter of water depth in each mu of pond; 7-10 days later, copper sulfate is put into the water body in the pond, and 0.75-1.25 kg of copper sulfate is put in per meter of water depth in each mu of pond; 4-5 days later, chlorine dioxide is put into the water body in the pond for disinfection, and the input amount of chlorine dioxide is 150-200 g; 2 days later, the water body is used for the roe hatching process.Pathogene can be killed at the water source, the method is widely applied in the fish breeding process, particularly for famous and special fishes such as micropterus salmoide laying viscid roes and odontobutis obscura with a long roe hatching cycle, the problem that the roes are attacked by saprolegniasis in the hatching process is effectively solved by using treated water body for roe hatching, and the hatching rate is high.

The invention discloses niclosamide ethanolamine slow-release water dispersion granules and a preparation process thereof. Raw materials comprise the following components in percentage by mass: 20-60 percent of niclosamide ethanolamine, 0.1-0.25 percent of polyvinyl alcohol, 1-10 percent of a dispersing agent, 4-10 percent of sodium tripolyphosphate and the balance of padding. The surfaces of the water dispersion granules are sprayed with polyvinyl alcohol protecting films, the completeness of the granules can be kept before the granules are immersed by water, and effective components are protected from being lost; after coming into contact with the water, a medicine is automatically disintegrated in the water and is uniformly dispersed in the water without the limitation of medicine application time, the medicine can be flexibly applied, the operation is convenient, playing of the medicine effect is ensured, the snail control effect is improved, and the aim of comprehensive prevention is achieved; the granules are smooth in surface and dust-free, the medicine application is environment-friendly, the medicine can be applied manually or can be applied by an unmanned aerial vehicle; compared with conventional granules, the niclosamide ethanolamine slow-release water dispersion granules have the advantages of low dosage, high efficiency and environmental friendliness.

A disclosed oncomelania-hupensis killing medicament niclosamide-ethanolamine-salt sustained-release granules is composed of the following compositions in percent by mass: 1%-50% of niclosamide ethanolamine salt, 0.1%-2.0% of a wetting agent, 0.1%-5.0% of a dispersant, 0.5%-10% of an excipient, 1%-5% of a coating material and the balance carrier. The oncomelania-hupensis killing medicament provided by the invention is increased in oncomelania-hupensis killing effect of niclosamide ethanolamine salt, is convenient to use, reduced in pollution and good in sustained release effect because of the granules form, is beneficial for being used in dry water-shortage bottomland and beach areas, and helps to establish a base for further controlling schistosomiasis.

The invention provides a compound preparation for killing wild fish and snail and a preparation method thereof; the compound preparation for killing the wild fish and the snail comprises the following components by weight parts: 40 to 50 parts of tea saponin, 60 to 80 parts of areca, 40 to 60 parts of niclosamide and 30 to 40 parts of zeolite powder; the preparation method uniformly stirs the raw material tea saponin, areca, niclosamide and zeolite powder by weight parts; the compound preparation for killing wild fish and snail promotes the dysfunction and the death of all organs and systems of the wild fish and the snail through the cooperation of the tea saponin, the areca and the niclosamide, has the advantages of strong killing effect and safety to shrimps and crabs, and effectively prevents the situations that the wild fish, the snail and the like fight over bait, nutrition, space and the like with the shrimps, the crabs and the like; and the preparation method is simple, and is applicable to the needs of scale industrial production.