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Niclosamide ethanolamine salt wettable powder as well as preparation method and application thereof

A technology of niclosamide ethanolamine salt and wettable powder, which is applied in the field of molluscicide preparations, can solve the problems of poor molluscicide effect, unsuitability to hard water, slow wetting, etc., and achieve caking prevention, small particle size distribution, and drug long-lasting effect

Active Publication Date: 2015-03-25
JIANGSU ESSENCE AGROCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It solves the technical problems that the existing wettable powder of niclosamide wets slowly, is not suitable for hard water, is prone to discoloration and flocculation, and leads to poor molluscicide effect

Method used

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  • Niclosamide ethanolamine salt wettable powder as well as preparation method and application thereof
  • Niclosamide ethanolamine salt wettable powder as well as preparation method and application thereof
  • Niclosamide ethanolamine salt wettable powder as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 6

[0039] In order to prove further, adopt the compound mixture of fatty alcohol polyoxyethylene ether and non-ionic hydroxyl polyethylene oxide block copolymer as dispersion wetting agent, in the niclosamide ethanolamine salt wettable powder of the present invention has excellent The important role played in the performance, the present invention has carried out the comparison of the test example of a series of different formulations, as follows:

[0040] Formula 1: 83.1% niclosamide ethanolamine salt, 5% alkylnaphthalene sulfonate formaldehyde complex sodium salt, 5% alkylphenol polyvinyl chloride ether, 2% magnesium aluminum silicate and the balance of white carbon black. The particle size of D95 is 3-5 μm.

[0041] Formula 2: 83.1% niclosamide ethanolamine salt, 5% lignosulfonic acid sodium salt, 5% butylnaphthalene sulfonic acid sodium salt, 2% magnesium aluminum silicate and the balance white carbon black. The particle size of D95 is 3-5 μm.

[0042] Formula 3: 83.1% of ...

Embodiment 7

[0051] Embodiment 7 application example

[0052] Indoor snail killing test with 83.1% niclosamide ethanolamine salt wettable powder

[0053] The niclosamide ethanolamine salt wettable powder of the present invention in Example 3 was used to prepare molluscicide products.

[0054] Preparation method: 12g of the wettable powder of embodiment 3 is dispersed in 2000g soft water (ppm150) to prepare a hard water suspension of the same concentration of niclosamide ethanolamine salt. Use dechlorinated soft and hard water as a control.

[0055] Experimental method: Place 30 oncomelanias in 5 white porcelain plates with an area of ​​40cm×30cm, spray 10mL, 20mL, 40mL, 80mL of soft water suspension and dechlorinated pure water with a watering can respectively; treat the other 5 in the same way Spray 10mL, 20mL, 40mL, 80mL of hard water suspension and hard water dechlorinated pure water with a watering can on the white porcelain plate, and observe the Oncomelania mortality after 6, 12, 2...

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Abstract

The invention provides niclosamide ethanolamine salt wettable powder as well as a preparation method and application thereof. The wettable powder is prepared from niclosamide ethanolamine salt, a dispersing and wetting agent, a suspension aid and an anti-caking agent, wherein the dispersing and wetting agent is a compound mixture of fatty alcohol-polyoxyethylene ether and a non-ionic hydroxyl polyethylene oxide block copolymer, and the use amount of the dispersing and wetting agent accounts for 8-15% of the total weight of the raw materials. By using the compound mixture of the fatty alcohol-polyoxyethylene ether and the non-ionic hydroxyl polyethylene oxide block copolymer as the dispersing and wetting agent, a unique steric hindrance effect is provided in the system, so that the stability of the system is effectively kept and the problems of slow wetting, color change and flocculation are solved; the wettable powder is short in wetting time, uniform in dispersion effect, relatively small in particle size distribution, capable of rapidly reaching a target site, free from flocculation for a long time and free from particle aggregation, so that the wettable powder has long-lasting efficacy and applicable to hard water. The wettable powder disclosed by the invention is applicable to the preparation of molluscicidal products and is good in molluscicidal effect.

Description

technical field [0001] The invention relates to the technical field of molluscicide preparations, in particular to a niclosamide ethanolamine salt wettable powder and a preparation method and application thereof. Background technique [0002] At present, niclosamide is the main molluscicide drug. It has no special smell, no irritation to the skin, low toxicity to humans and animals, and does not damage crops. It can be directly diluted with water for application. Moreover, the medicine has a large mollusc killing effect and a long-lasting effect. But the dissolubility and dispersibility of various powders of existing niclosamide are not ideal, not only the wetting time is long, and after diluting with water, the water surface changes from bright yellow to reddish brown soon. At the same time, flocculation occurs in the aggregation of drug particles, which not only pollutes the water surface, but also the active ingredients cannot be well dispersed evenly. The charge effect ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/40A01N25/14A01N25/30A01P9/00
Inventor 石伟山刘炳良戴焰林张申伟
Owner JIANGSU ESSENCE AGROCHEM
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