The invention discloses an anion ceramic ball and a preparation method of the anion ceramic ball. The anion ceramic ball is prepared from the following raw materials in parts by weight: 50-70 parts of Gui gemstone, 30-50 parts of elbaite, 25-45 parts of basalt, 10-15 parts of potash feldspar, 8-16 parts of zeolite, 7-13 parts of germanite, 10-15 parts of kaolin clay, 5-10 parts of halloysite, 12-18 parts of bryozoatum, 6-12 parts of shell powder, 15-20 parts of cobblestone and 10-15 parts of pearl powder. The anion ceramic ball disclosed by the invention is stable in ion generation performance and durable in effectiveness, can be widely applied to the treatment of drinking water, enables water molecular groups to become small, can be used for increasing the dissolving capacity and penetrability of water and reducing the oxidation-reduction potential of water, ensures that the water quality is weakly alkaline, and is helpful for regulating the acidity and alkalinity of a human body; the anion ceramic ball can be used for dissolving out micro-elements such as calcium, magnesium, sodium and potassium and various mineral substances required by the human body, and also has the functions of removing peculiar smell and residual chlorine of water and removing harmful metal substances in water.