Components and preparation method of beta-lactam injection

Abstract

The invention discloses the components and preparation method of beta-lactam injection. The beta-lactam injection comprises 5 to 20 percent of beta-lactam antibiotics, 0.05 to 5 percent of suspending agent, 0.005 to 0.3 percent of antioxygen, 0.1 to 0.2 percent of nonionic surfactant and the balance of vegetable oil or grease for injection. The injection can be used for preventing and curing animal bacterial infectious diseases and can be injected hypodermically or in muscle and be applied through breast for a few times. The preparation method provided by the invention comprises: firstly, making the antibiotics and the antioxygen into micro powder and making the suspending agent into fine powder; secondly, adding the vegetable oil or grease for injection, which is sterilized at high temperature, into the fine powder of the suspending agent, heating the mixture, uniformly mixing the mixture and keeping the mixture in a sterile environment to cool the mixture to room temperature for later use; and finally, transferring the prepared oil or grease added with the suspending agent to a colloid mill, adding medicament micro powder, the antioxygen and the non-ionic surfactant with stirring, and performing uniform mixing and sterilization to obtain the beta-lactam injection.

Description

technical field [0001] The invention relates to a composition of β-lactam injection and a preparation method thereof. Background technique [0002] β-lactam antibiotics (β-lactams) refer to a large class of antibiotics with a β-lactam ring in their chemical structure, including penicillins, cephalosporins, and atypical β-lactam antibiotics. Such antibiotics have the advantages of strong bactericidal activity, low toxicity, wide indications and good clinical curative effect. Commercially available penicillins or cephalosporins injections are mainly powder injections, which need to be prepared and used immediately, otherwise they will decompose quickly and lose their antibacterial activity. [0003] Usually β-lactam antibiotics prevent and treat animal bacterial infection. When the drug dosage form is powder injection, it is individually packaged and needs to be injected in time after preparation. Once used up, the packaging cost of powder injection, especially penicillin ant...

AI Technical Summary

Problems solved by technology

[0003] Usually β-lactam antibiotics prevent and treat animal bacterial infection. When the drug dosage form is powder injection, it is individually packaged and needs to be injected in time after preparation. Once used up, the packaging cost of powder injection, especially penicillin antibiotics, far exceeds the drug itself. In addition, in intensive production, the powder injection needs to be dissolved and injected, which is very cumbersome to operate and may easily cause a delay in the administration time

After ordinary injections are injected into animals, the typical situation is that the drug concentration in the whole body is much higher than the therapeutic concentration at first, then gradually decreases to the therapeutic concentration, and finally drops to the ineffective drug concentration, and ordinary injections often need to be administered twice a day for continuous administration 3 to 5 days, this method is difficult to operate in practice, and causes a greater stress response to the animal

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