595 results about "Amoxicillin" patented technology

The invention discloses a veterinary suspension containing amoxicillin, colistin sulfate and prednisolone and a preparation method thereof. The veterinary suspension adopts the amoxicillin, the colistin sulfate and the prednisolone as active ingredients. The preparation method of the veterinary suspension containing the amoxicillin, the colistin sulfate and the prednisolone comprises the following steps of: (1) dissolving or dispersing a suspending agent, an antioxidant and a preservative in a hot dispersion medium to obtain a solution (A); (2) adding 40-80 percent of dispersion medium in a formula ratio in a colloid mill, starting the colloid mill, then slowly adding the solution (A) and adding a wetting agent while stirring after the solution (A) is fully added; (3) sequentially adding the amoxicillin, the colistin sulfate and the prednisolone after fully adding all the accessories, and grinding by adopting two alternate modes, i.e. an endless grinding mode and a non-endless grinding mode; and (4) detecting the grain fineness, stopping grinding when the grain fineness accords with the requirement, adding the dispersion medium to the formula ratio, mixing, canning, sealing and sterilizing to obtain the veterinary suspension containing the amoxicillin, the colistin sulfate and the prednisolone.

PCT No. PCT / EP96 / 03253 Sec. 371 Date Jan. 15, 1998 Sec. 102(e) Date Jan. 15, 1998 PCT Filed Jul. 16, 1996 PCT Pub. No. WO97 / 04086 PCT Pub. Date Feb. 6, 1997Penicillin G acylase is immobilized by covalent bonding to a crosslinked mixture of a gelled gelling agent such as gelatin and a polymer containing free amino groups such as alginate amine, chitosan or polyethylene imine. The immobilized penicillin G acylase provides a higher synthesis / hydrolysis ratio as compared to immobilizing with other carriers when producing beta -lactam derivatives by a condensing reaction of an amino beta -lactam with an acylating agent. The acylating agent may be a derivative of D-phenylglycine, a derivative of D-p-hydroxyphenylglycine or a derivative of D-2,5-dihydro-phenylglycine. Examples of beta -lactam derivatives that can be produced are amoxycillin, ampicillin, cephaclor, cephadroxil, cephprozil, cephalexin and cephradine.

The invention relates to an amoxicillin preparation and a preparation method thereof. The amoxicillin preparation comprises 5-50 parts of amoxicillin, 3-38 parts of a stabilizer, 0.2-10 parts of a solubilizer, 0.1-1 part of a complexing agent and 1-91.7 parts of an auxiliary material. The preparation method comprises the following steps: the stabilizer and the solubilizer are ground and sieved by a sieve with 80-120 meshes and fed into a mixing tank according to a formula to be uniformly mixed with amoxicillin; the auxiliary material is ground and sieved by a sieve with 80-100 meshes and fed into the mixing tank according to a formula to be uniformly mixed, and a finished product is obtained through sub-packaging. The amoxicillin preparation has high water solubility and high stability, and according to 6-mouth acceleration test, the content of amoxicillin is in a prescribed range all along; the use requirement of a doser of a large-scale farm is met; an aqueous solution of the amoxicillin preparation is not prone to be influenced by objective factors such as the temperature, metal ions, ph and the like, the content of effective components can keeps unchanged for 24 hours, and the effect of treatment of livestock colibacillosis caused by Gram-negative bacteria is improved substantially.

The invention discloses a technology for preparing amoxicillin by a straight-through method. The technology takes a penicillin degreasing fluid as a starting raw material; 6-APA (6-amino penicillanic acid) crystallization, suction filtration, washing and drying steps are saved; the amoxicillin can be prepared without obtaining solid 6-APA via separation; and the prepared amoxicillin meets a requirement of a medicinal standard. The technology saves an operation procedure, reduces the labor intensity of production personnel, lowers the production cost, reduces environmental protection pressure, avoids contact between the production personnel and 6-APA dry powder, and reduces anaphylaxis.

The invention provides amoxicillin granules and the production method thereof, in particular relates to a method of adopting the micropowder technology to prepare amoxicillin granules. The method is characterized in that the method includes the steps that a superfine pulverizer is used to pulverize amoxicillin to obtain fine powder with the particle size of 25um-50um. The amoxicillin granules prepared by the method have the advantages of good dissolution, good stability, greatly reducing the dosage of auxiliary material, reducing the toxic and side effects, simple preparation process and easy operation.

The invention relates to a compound capsule and a preparation method thereof. The capsule comprises lansoprazole enteric coated pellets, clarithromycin stomach-soluble pellets and amoxicillin stomach-soluble pellets. The compound capsule is administered twice one day based on the following dose each time: lansoprazole 20-40 mg, clarithromycin 400-600 mg, and amoxicillin 900-1100 mg. The capsule provided by the invention has a distinct effect on peptic ulcer, is used for thoroughly killing helicobacter pylori, and has the advantages of quick action, strong effect, improved bioavailability, convenience in administration and low cost.

The present invention relates to the field of drug synthesis, in particular to a method for preparing amoxicillin sodium. The method of the present invention comprises the following steps: (1) preparation of acid anhydride; (2) preparation of 6-APA solution; (3) condensation: Move the 6-APA salt solution into the mixed acid anhydride reaction bottle, and time it for 3 hours; (4) Hydrolysis: add the condensation solution of step (3) to the hydrolyzed solution; (5) Crystallization: Leave the crystal to grow for 1 hour and then stir to grow the crystal for 1 hour (6) Suction drying: wash with water first, then wash with acetone, and dry in vacuum at 40° C. for 3 hours to obtain amoxicillin.

The invention relates to a method for comprehensively recovering effective ingredients in amoxicillin mother liquid prepared by an enzyme process. The method comprises the following steps: (1) concentrating the amoxicillin mother liquid, namely adjusting the pH value of the amoxicillin mother liquid prepared by the enzyme process to be 8.0-9.5, and performing nanofiltration and concentration to obtain concentrated mother liquid; (2) synthesizing amoxicillin under enzyme catalysis, namely adjusting the pH value of the concentrated mother liquid to be 5.8-7.0, and converting 6-APA (6-amino penicillanic acid) and D-methyl hydroxyphenyl glycinate into amoxicillin in the presence of immobilized penicillin acylase for synthesis; (3) preparing D-hydroxyphenyl glycine concentrated liquid by ultrafiltration and nanofiltration, namely separating after the enzyme catalysis reaction is ended to obtain amoxicillin crystals and secondary amoxicillin mother liquid, and performing ultrafiltration and nanofiltration on the secondary mother liquid to obtain the D-hydroxyphenyl glycine concentrated liquid; (4) crystallizing D-hydroxyphenyl glycine. According to the method, 6-APA and D-methyl hydroxyphenyl glycinate remained in the mother liquid are consumed through an indirect process of synthesizing amoxicillin under enzyme catalysis, the product quality of D-hydroxyphenyl glycine is improved, and the yield of D-hydroxyphenyl glycine is increased.

The present invention relates to an amoxicillin antimicrobial containing nano silver. its preparation method and application. At the normal temperature the nano silver and amoxicillin are uniformly mixed so as to obtain the invented amoxicillin antimicrobial containing nano silver. The tests show that said invention has stronger antimicrobial effect.