473results about How to "Improve hydrolysis efficiency" patented technology

The invention discloses a preparation method for tenofovir disoproxil fumarate, which comprises the following steps of: A, performing condensation reaction adenine and (R)-propylene carbonate which serve as raw materials to generate (R)-9-(2-hydroxypropyl) adenine; B, performing condensation reaction on the (R)-9-(2-hydroxypropyl) adenine and p-methylphenyl mesyloxy diethyl phosphonate under the catalysis of potassium alcoholate to prepare (R)-9-[2-(diethyl phosphonyl methoxy) propyl] adenine; C, reacting the (R)-9-[2-(diethyl phosphonyl methoxy) propyl] adenine obtained by the step B with para-toluenesulfonate acyl chloride to protect an amino group at bit four to prepare (R)-4-(p-toluenesulfonyl)-9-[2-(diethyl phosphonyl methoxy) propyl] adenine; D, hydrolyzing the (R)-4-(p-toluenesulfonyl)-9-[2-(diethyl phosphonyl methoxy) propyl] adenine obtained by the step C under a strong acid condition to obtain (R)-4-(p-toluenesulfonyl)-9-[2-(dihydroxy phosphonyl methoxy) propyl] adenine; and E, reacting the (R)-4-(p-toluenesulfonyl)-9-[2-(dihydroxy phosphonyl methoxy) propyl] adenine obtained by the step D with mercapto-benzene under a weak alkaline condition to remove a para-toluenesulfonate group to obtain the tenofovir. The invention aims to provide the preparation method for the tenofovir, which is low in cost, safe in process and good in product quality, and is suitable for industrialization.

The invention discloses an efficient enzyme hydrolysis method of lignocellulose biomass, comprising the following steps: pretreating the lignocellulose biomass through high-temperature aqueous water to obtain a lignocellulose raw material to be used as a substrate; dispersing the substrate into an acetic acid-sodium acetate buffer solution in a certain concentration; adding a nonionic surfactant and cellulose; stirring the materials; hydrolyzing for some time; adding a certain amount of materials twice; and simultaneously adding the nonionic surfactant and the cellulose; and continuously hydrolyzing to obtain a saccharide compound and lignocellulose residues. In the method provided by the invention, high-temperature aqueous water pretreatment, batch charging, nonionic surfactant adding and stirring and an enzyme hydrolysis process are coupled, thus the hydrolysis efficiency is high, the concentration of the enzymolysized lignocellulose raw material can be greatly improved; the concentration reaches 30%; the sugar generation concentration and the hydrolysis efficiency are high under the condition of high-concentration lignocellulose raw materials; the enzymolysized raw material concentration is improved; and simultaneously the high-concentration sugar is produced, thus improving the hydrolysis efficiency, and realizing the efficient enzyme hydrolysis of the lignocellulose biomass.

The invention relates to a novel method for preparing nano cellulose by hydrolyzing a cellulose raw material with formic acid by using a metal salt catalyst. In the method, the metal salt is utilized to catalyze the formic acid to hydrolyze the cellulose raw material, so that the hydrolysis efficiency is greatly enhanced, thereby lowering the formic acid concentration and further saving the cost. Besides, the method has the advantages of milder reaction conditions and controllable reaction, and is simple to operate.

The invention discloses a method to prepare composite amino acid liquid by abandoned protein, which comprises steps: a. pretreating the material, smashing and removing impurity to soya bean waste, rape seed cake and cotton cake; sieving, dipping with dilute sulphuric acid or muriatic acid; filtering supernatant and cooking; b. mixing material; c. hydrolyzing with neutral proteased at thermostatic condition; d. hydrolyzing with edible pure muriatic acid on condition of thermostatic and pressure; e. neutralizing with edible caustic soda, filtering, and adjusting with caustic soda solution pH value to 4.5~5.0; f. matching and mixing. This method is simple and high efficient.

The invention relates to a resourced recovering and utilizing method for waste cotton fabric, in particular to a technology for recovering polyester and cotton fiber from waste polyester cotton blended fabric and using the polyester and the cotton fiber during the production of fermentable sugar, and belongs to the field of resourced cycling and reutilizing of solid waste. According to the resourced recovering and utilizing method, concentrated phosphoric acid is used as a solvent, a reaction is conducted under the conditions that the mass fraction of the phosphoric acid is 82 to 86 percent, the solid-liquid ratio is 1:10 to 1:30, the reaction temperature is 45 to 60 DEG C, and the reaction time is 2 to 18 hours; the cotton fiber in the polyester cotton blended fabric is completely dissolved, so as to enable the polyester to be isolated and recovered by one hundred percent; then water is added to a solution to dilute the solution, so as to enable cellulose to be regenerated and obtain regenerative cellulose with a low cleanliness degree and a low polymerization degree, which is applicable to enzymatic hydrolysis; and after the regenerative cellulose is subjected to the enzymatic hydrolysis, the fermentable sugar is generated to be used as a carbon source for fermenting and producing bio-based products. Waste liquid is distilled and the concentrated phosphoric acid is recovered to be circularly used. The resourced recovering and utilizing method is applicable to the polyester cotton blended fabric formed in any proportion, has the advantage of relatively low energy consumption and is simple to operate; and the polyester can be recovered by one hundred percent, the concentrated phosphoric acid can be simultaneously recovered to reduce costs, and the cotton fiber component is utilized to produce bio-based sources or bio-based products.

The invention discloses a phosphotungstic acid-metal organic skeleton used for catalyzing hydrolysis of cellulose, and a preparation method and application thereof. According to the invention, organic ligand with strongly electronegative groups and basic groups is screened out and participates in coordination reaction of a metal organic skeletal material so as to realize functionalization, phospho-tungstic acid is directly added into a synthesis system, and immobilization is realized in the process of synthesis. The prepared phosphotungstic acid-metal organic skeleton reduces the frequency of contact with glucose through formation of a hydrogen bond with cellulose so as to reduce side reaction of glucose under the catalysis of acid, high glucose selectivity is obtained, and oriented conversion of cellulose to glucose can be realized; meanwhile, the effect of the hydrogen bond can weaken the effect of a hydrogen bond in cellulose, reduces the crystallization degree of cellulose, enables cellulose to be easier to hydrolyze and improves hydrolysis efficiency.

The invention relates to a method for preparing bacterial cellulose by using wheat straw, which comprises: pretreating the wheat straw in ionic liquid at 90 to 120 DEG C for 15 minutes to 21 hours; adding deionized water; stirring for regeneration; adding cellulose for enzymolysis, and obtaining enzymolysis solution; detoxifying the enzymolysis solution to obtain the culture medium for culturing the bacterial cellulose; adding yeast extract and tryptone to prepare the culture medium; adding seed liquid of bacterial cellulose producing bacteria; and culturing the bacteria at 20 to 30 DEG C for 8 to 28 days and obtaining the bacterial cellulose. In the invention, usually waste or burnt crop straw byproducts are used as raw materials, a cheap carbon source is developed, environmental pollution is reduced, and the bacterial cellulose can be used for producing products with high added values and can create good economic benefit for the related industry.

The invention discloses a method for pre-treating a lignocelluloses raw material for enzyme hydrolysis in combination of strong phosphoric acid and hydrogen peroxide. The method comprises the following steps: using strong phosphoric acid as a solvent and hydrogen peroxide as a catalyst to remove lignin and hemicellulose in the lignocelluloses raw material, adding water in the solution to regenerate cellulose in the solution so as to obtain regenerated cellulose which is low in crystalline and polymerization degree and suitable for enzyme hydrolysis, using the regenerated cellulose after filtering and separating for the enzyme hydrolysis to produce fermentable carbohydrate, wherein the hydrolysis efficiency is 75-100%. The method is suitable for lignocelluloses raw materials in different types such as crop stalks, woods and bamboos, wild herbs or woody and the like, the method is simple in operation, low in energy consumption, clean and non-pollution, low in requirement on grain size of raw materials, and strong in raw material adaptability, and the pre-treatment effect is perfect.

The invention discloses a preparation method of high-purity arctigenin. The preparation method of the high-purity arctigenin does not need a heating return flow method to extract arctigenin constituents, does not need an enzymolysis method and a column chromatography, and directly uses ethyl acetate diacolation to extract arctiin in burdock, the potential of hydrogen (PH) value of a diacolation concentrated solution is adjusted to be 3.0-4.0, the arctiin is directly hydrolyzed to become an arctigenin crude product, and an opposite phase preparative liquid chromatography optimized by a large number of experiments is adopted to obtain the high-purity arctigenin. The preparation method of the high-purity arctigenin is reasonable and in the entire preparation process design, high in preparation efficiency, strong in operability, and suitable for industrialized mass production.

The invention discloses a sulfonated carbonaceous solid acid catalyst as well as a preparation method and application thereof to a microcrystalline cellulose hydrolysis process. The density of a sulfonic acid group on the surface of the catalyst is 0.30 to 0.80mmol / g and the density of an oxygen-containing group is 1.00 to 2.50mmol / g; the density ratio of the sulfonic acid group to the oxygen-containing group is controlled to be from (1 to 1.25) to (1 to 8.33). The catalyst has high hydrolysis efficiency and a preparation technology is simple and is suitable for large-scale production.