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77 results about "Phenylethanolamine" patented technology
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Phenylethanolamine (sometimes abbreviated PEOH), or β-hydroxyphenethylamine, is a trace amine with a structure similar to those of other trace phenethylamines as well as the catecholamine neurotransmitters dopamine, norepinephrine, and epinephrine. As an organic compound, phenylethanolamine is a β-hydroxylated phenethylamine that is also structurally related to a number of synthetic drugs in the substituted phenethylamine class. In common with these compounds, phenylethanolamine has strong cardiovascular activity and, under the name Apophedrin, has been used as a drug to produce topical vasoconstriction.
Phenylethanolamine compounds useful as beta 3 agonists, process for producing the same, and intermediates in the production of the same
PCT No. PCT / JP96 / 03097 Sec. 371 Date Apr. 24, 1998 Sec. 102(e) Date Apr. 24, 1998 PCT Filed Oct. 24, 1996 PCT Pub. No. WO97 / 15549 PCT Pub. Date May 1, 1997The present invention relates to phenylethanolamine compounds represented by general formula [I]: (where R1 represents hydrogen or halogen; R2 represents hydrogen, hydroxy, lower alkoxy, lower alkoxy substituted with one or two lower alkoxycarbonyl or carboxy groups, lower alkoxy substituted with lower alkylaminocarbonyl which may be substituted with lower alkoxy, lower alkoxy substituted with cyclic aminocarbonyl of 4 to 6 carbon atoms, lower alkoxycarbonyl or carboxy; R3 represents hydrogen, hydroxy, lower alkoxy or lower alkoxy substituted with one or two lower alkoxycarbonyl or carboxy groups; R2 and R3 may be bonded to each other to form methylenedioxy substituted with carboxy or lower alkoxycarbonyl; and m and n are 0 or 1), and their pharmacologically acceptable salts, which have a potent beta 3 adrenergic stimulating effect and high beta 3 adrenergic receptor selectivity, as well as to processes for their production and intermediates in their production.
Owner:TT PHARMA
Method for simultaneously analyzing and detecting residual veterinary drug compositions in animal tissue
InactiveCN103713056AImprove linearitySimple processing and analysisComponent separationSulfur drugSulfanilamide
A disclosed method for simultaneously analyzing and detecting residual veterinary drug compositions in animal tissue comprises: performing homogenate on an animal tissue sample by 50% acetonitrile and ethanol, performing ultrasonic extraction and hexane purifying, and performing further precipitation by acetonitrile and ethanol, concentrating, utilizing UPLC-MS / MS to perform multi-reaction monitoring (MRM) determination under the negative ion mode, and quantifying according to a standard curve and an external standard method, detecting and calculating to obtain the content of 46 residual veterinary drug compositions in animal tissue. The method is applicable to present commonly-used veterinary drugs such as 18 kinds of quinolone drugs, 22 kinds of sulfanilamide drugs, dapsone, phenylethanolamine A, amoxicillin, adamantanamine, rimantadine, ethoxyquin and the like, and is capable of performing one-step simultaneous rapid accurate detection, and the application scope of the method is enlarged.
Owner:INSPECTION & QUARANTINE TECH CENT OF NINGBO ENTRY EXIT INSPECTION & QUARANTINE BUREAU
Graphene-poly ionic liquid composite material, and preparation method and application thereof
InactiveCN103980424AImprove conductivityLarge specific surface areaMaterial electrochemical variablesCvd grapheneIonic liquid
Owner:JIAXING UNIV
Phenethanolamine-derived haptens, immunogens, antibodies and conjugates
The present invention relates to a method for preparing haptens of formulae I and II that are useful in the preparation of immunogens, antibodies and conjugates, for use in competitive immunoassays for the detection of ractopamine, isoxsuprine and ritodrine. The haptens are prepared by reacting a phenylethanolamine derivative of formula D with a phenylalkylcarbonyl derivative of formula E: in which, in formula I, Z1 is a crosslinker and Z2 is H and, in formula II, Z1 is H and Z2 is a crosslinker.
Owner:NORTHERN BANK LTD
Immune colloidal gold detection card for phenylethanolamine A and preparation method thereof
The invention discloses an immune colloidal gold detection card for phenylethanolamine A and a preparation method thereof, and relates to the technical field of detection of beta-epinephrine receptor stimulants. A test paper in a shell of a detection card consists of a polyvinyl chloride (PVC) rubber plate, a sample cushion, a colloidal gold combined cushion, a coating membrane and a water sucking cushion, wherein a colloidal gold membrane is a glass cellulose membrane containing a phenylethanolamine A monoclonal antibody; the coating membrane is a nitrocellulose membrane; a line T and a line C are arranged on the coating membrane; the line T coating is provided with a phenylethanolamine A protein conjugate; and the line C is coated with a goat-anti-mouse IgG antibody. The immune colloidal gold detection card is effectively used for rapidly detecting the phenylethanolamine A, so that the detection is convenient and quick, and the detection result is accurate.
Owner:JIANGSU WISE SCI & TECH DEV
Enzyme-linked immunoassay kit for detecting phenylethanolamine A
The present invention discloses an enzyme-linked immunoassay kit for detecting phenylethanolamine A. The kit contains a specific antibody of the phenylethanolamine A, wherein the specific antibody is packaged separately. The specific antibody of the phenylethanolamine A is a polyclonal antibody or a monoclonal antibody prepared by adopting a conjugate of the phenylethanolamine A and a carrier protein as immunogen. According to the present invention, an ELISA competition method is adopted to qualitatively or quantitatively detect the residue level of the phenylethanolamine A drug in animal urine, serum, tissue (muscle, liver and kidney), feed, and other samples; the pre-treatment requirements on the sample are low; the animal urine and the animal serum can be detected directly; the tissue samples and the feed can be loaded on the kit after sample liquid extraction; a large number of samples can be concurrently and rapidly detected; the detecting method has characteristics of simpleness and time saving, and the result can be obtained within one hour; and the lowest detection limit of the pig urine sample is 0.5 mug / L. The kit of the present invention has characteristics of high specificity, high sensitivity, high precision and high accuracy, and plays important roles in detections of the phenylethanolamine A residue in animal products.
Owner:CHINA INST OF VETERINARY DRUG CONTROL
Enzyme-linked immunoassay kit for detecting phenylethanolamine A by direct competition method
InactiveCN102539747AQuick checkLow pre-processing requirementsMaterial analysisElisa kitHorseradish peroxidase
The invention discloses an enzyme-linked immunoassay kit for detecting phenylethanolamine A by a direct competition method. The enzyme-linked immunoassay kit for detecting phenylethanolamine A provided by the invention comprises an enzyme label plate coated by phenylethanolamine A specific antibodies, and a phenylethanolamine A horseradish peroxidase marker. The enzyme-linked immunoassay kit for detecting phenylethanolamine A of the invention is sensitive, rapid, accurate, and is mainly used for screening of large quantities of samples; main reagents in the kit are provided in the form of operating fluid, and the kit is convenient for using, has the characteristics of high specificity, high sensitivity, high precision, high accuracy, and the like, can rapidly detect residual phenylethanolamine A in feed and animal products.
Owner:于洪侠
Method for detecting content of phenylethanolamine A by utilizing CdTe quantum dot
ActiveCN105738330AReduce surface defectsEnables trace detectionFluorescence/phosphorescenceLuminescent compositionsFluoProbesP phosphate
The invention relates to a method for detecting the content of phenylethanolamine A by utilizing a CdTe quantum dot. The method takes mercaptopropionic acid as a stabilizer; the CdTe quantum dot prepared by a microwave radiation heating method is used as a fluorescent probe; and the method for detecting the content of the phenylethanolamine A is established based on a fluorescent intensity enhancing effect on the CdTe quantum dot by the phenylethanolamine A. The method comprises the following steps: uniformly mixing the CdTe quantum dot with the phenylethanolamine A of a substance to be detected in a phosphate buffering solution; standing for 15 minutes; and detecting the fluorescent intensity of a system by adopting a molecular fluorescence photometer so as to realize trace detection of the phenylethanolamine A. The method has the advantages of high detection sensitivity, simplicity and convenience for operation, short detection time, low analysis cost, relatively low detection limit and relatively high standard recovery rate.
Owner:INST OF AGRI PROD QUALITY SAFETY & STANDARD JIANGXI ACAD OF AGRI SCI
Preparation method of 4-(nitrobenzophenone)-3-morpholone and method for preparing rivaroxaban by using 4-(nitrobenzophenone)-3-morpholone
ActiveCN103980221ALow priceSimple operation processOrganic chemistryMorpholineTert-Butyloxycarbonyl protecting group
Owner:山东康美乐医药科技有限公司
Chemiluminescence immunodetection kit used for detecting phenylethanolamine A
InactiveCN103792226AReduce testing costsThe electrophoretic method is fast and easyChemiluminescene/bioluminescenceBiological testingCouplingCarrier protein
The invention provides a chemiluminescence immunodetection kit used for detecting phenylethanolamine A, and belongs to the immunological detection field. The kit comprises an opaque white ELISA plate covered with a phenylethanolamine A / carrier protein coupling compound, a phenylethanolamine A standard substance, a phenylethanolamine A / peroxidase labeled antibody working solution, a luminous substrate liquid, a concentrate diluent and a concentrate washing liquid. The phenylethanolamine A / carrier protein coupling compound is obtained by coupling the phenylethanolamine A and a carrier protein through a mixed anhydride method or a carbodiimide method. The concentrate washing liquid comprises 0.05% of tween-20. Compared with a traditional enzyme linked immunosorbent assay method, the kit has characteristics of higher sensitivity, shorter detection time and lower cost and can be used for detection of the residue amount of the phenylethanolamine A in animal urine, blood samples, tissue, viscera, and other samples.
Owner:JIANGSU WISE SCI & TECH DEV
Metal rust-preventive oil comprising coconut oil fatty acid diethanolamide
InactiveCN103215594AGood gas phase anti-rust effectExcellent contact rust resistanceMethacrylateMicrocrystalline wax
The invention discloses metal rust-preventive oil comprising coconut oil fatty acid diethanolamide. The oil is prepared from the raw materials of: No.120 solvent oil, a silane coupling agent KH540, a silane coupling agent KH 602, microcrystalline wax, isobutyl methacrylate, modified nano-grade shale powder, an antioxidant 1010, a composite film-forming material, polyethylene glycol, isobutyl alcohol, an antioxidant 1076, coconut oil fatty acid diethanolamide, barium petroleum sulfonate, petroleum sulfonate, benzotriazole, 2-aminoethyl heptadecenyl imidazoline, magnesium naphthenate, nonylphenol polyoxyethylene ether, Span 80, an antioxidant T501, and phenylethanolamine A. The rust-preventive oil provided by the invention has excellent contact rust resistance and good gas-phase rust resistance. The rust-preventive oil provided by the invention provides good gas-phase rust resistance and contact rust resistance for steel and brass.
Owner:ANHUI FANCHANG COUNTY WANNAN VALVE CASTING
Phenethanolamine derivatives as beta2 adrenoreceptor agonists
InactiveCN101395150AImproving immunogenicityImprove methodOrganic chemistryRespiratory disorderDiseaseCOPD
The present invention relates to compounds according to formula (I), a process for preparing them, the intermediate compounds of the process and the use of the compounds in the manufacture of a medicament for use in treating diseases such as ARDS, pulmonary emphysema, bronchitis, bronchiectasis, COPD, asthma and rhinitis. The compounds are beta2 adrenoreceptor agonists.
Owner:ASTRAZENECA AB
Phenolethanolamine substance rapid detection card and detection method thereof
The invention discloses a phenolethanolamine substance rapid detection card and a detection method thereof, and belongs to the technical field of phenolethanolamine substance detection. The phenolethanolamine substance rapid detection card is provided with a test bar in an outer shell, and the test bar is formed by pasting a sample pad, a colloidal gold (or latex particle) membrane, a cellulose nitrate membrane and a water absorbing membrane on a supporting backboard in turn, wherein the colloidal gold (or latex particle) membrane is a glass fiber membrane containing an anti-phenylethanolamine monoclonal antibody colloidal gold (or latex particle) marker; and the cellulose nitrate membrane is provided with two detection strips in the transverse direction, one detection strip contains a phenylethanolamine protein conjugate, and the other detection strip is a quality control strip containing anti-rabbit antibody or anti-rat antibody. The phenolethanolamine substance rapid detection card has the advantage that: an immunological method is used for directly detecting the content of a phenolethanolamine feed additive in samples of feed, tissue sample, urine or serum and the like. The phenolethanolamine substance rapid detection card is easy to prepare, is convenient and quick to use, and is accurate in result.
Owner:无锡安迪生物工程有限公司
Indirect-competition-law enzyme linked immunosorbent assay kit for detecting phenylethanolamine A
InactiveCN102520158AQuick checkLow pre-processing requirementsMaterial analysisElisa kitScreening Examination
The invention discloses an indirect-competition-law enzyme linked immunosorbent assay kit for detecting phenylethanolamine A, which comprises a phenylethanolamine A specific antibody, phenylethanolamine A and conjugates and DON-HRP-Conjugated of carrier protein. The indirect-competition-law enzyme linked immunosorbent assay kit for detecting phenylethanolamine A is sensitive, fast and accurate and is mainly used for screening examination of large quantities of samples. Main reagents in the assay kit are all provided in the form of working solution. The indirect-competition-law enzyme linked immunosorbent assay kit for detecting phenylethanolamine A has the advantages of being convenient to use, high in specificity, sensitivity, accuracy and the like and capable of fast detecting residual phenylethanolamine A in feedstuff and animal products.
Owner:于洪侠
Phenylethanolamine-based NMDA receptor antagonists
Described herein are enhanced N-methyl-D-aspartate (NMDA) receptor antagonists, pharmaceutical compositions thereof, and their methods of use and treatment, e.g., of Formula (I):wherein one or more of R1, R2, R3, R4, R5, or the ring formed by the joining of R1 and R2, is a hydrophobic moiety which confers enhanced antagonist activity as compared to existing NMDA receptor antagonists, e.g., ifenprodil. Compounds described herein are designed based on the discovery that ifenprodil binds within the allosteric domain of the GluN1 / GluN2B NMDA receptor, particularly at the interface between GluN1 and GluN2B subunits. In silico methods are further described herein.
Owner:COLD SPRING HARBOR LAB INC
R-bambuterol, its preparation and therapeutic uses
InactiveUS20050171197A1Less inotropicLess chronotropic effectBiocideCarbamic acid derivatives preparationEnantiomerTreatment use
R-enantiomer of Bambuterol, its preparation and therapeutic uses are disclosed. A composition includes R-Bambuterol or its therapeutically acceptable salt. A composition of R-Bambuterol includes at least 80% by weight of the R-enantiomer and not more than 20% by weight of the S-enantiomer based on a total weight of the Bmbuterol. A process includes: (a) asymmetrically reducing a suitably substituted and suitably protected bromoacetophenone compound to a chiral phenyl-bromoethanol comprising a primary bromo group and a secondary hydroxyl group; (b) displacing the bromo group by a suitably substituted and optionally protected primary amine to produce a protected chiral phenylethanolamine, and (c) removing the protecting groups to convert the protected chiral phenylethanolamine to a chiral phenylethanolamine.
Owner:TAN WEN DR
New phenyl ethyl amine compounds having beta 2-receptor excitation and its producing method
The present invention relates to phenyl ether amine compound with beta 2-receptor excitation and its preparation process. The compound may be used to treat asthma and bronchitis effectively. The compound is synthesized with two kinds of compounds in anhydrous alcohol or aromatic hydrocarbon solvent as reflux temperature via reaction of 10-15 hr. The present invention provides one new way for treating asthma and bronchitis.
Owner:SHENYANG PHARMA UNIVERSITY +1
Phenylethanolamine A molecularly imprinted membrane, preparation method thereof and applications thereof
InactiveCN103599755AAchieve specific identificationRegular shapeIon-exchange process apparatusSemi-permeable membranesSeparation technologyMicrosphere
The invention discloses a phenylethanolamine A molecularly imprinted membrane and a preparation method thereof. The method comprises steps of performing prepolymerization after phenylethanolamine A and methacrylic acid are mixed; adding ethylene glycol dimethacrylate and 2,2'-azodiisobutyronitrile into the system after prepolymerization to obtain a polymerization system; dipping a PVDF membrane in the polymerization system; subjecting the dipped PVDF membrane to a polymerization reaction in a nitrogen environment; and washing the PVDF membrane with methanol after the polymerization reaction is finished. Beneficial effects of the phenylethanolamine A molecularly imprinted membrane and the preparation method are that: the phenylethanolamine A molecularly imprinted membrane has advantages both of molecular imprinting technology and membrane separation technology; and the advantages comprise that (1) specific space sites and functional groups in the phenylethanolamine A molecularly imprinted membrane can achieve specific recognition of an object to be detected, and (2) compared with traditional molecularly imprinted microsphere materials, the molecularly imprinted membrane material provided by the invention is more stable, and more ordered in form, and can be used directly without tedious preparation processes such as a column packing process, etc..
Owner:INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
Preparation method and application of phenylethanolamine A molecularly-imprinted material
InactiveCN102527358AEasy to makeEasy to operateComponent separationOther chemical processesAdsorption equilibriumCompound (substance)
The invention discloses a preparation method of a phenylethanolamine A molecularly-imprinted material, which is characterized by comprising the following steps of: (1) activating silica gel; (2) carrying out double-bond bonding on the silica gel; (3) carrying out chemical grafting on the surface of the silica gel and obtaining grafting particles; and (4) preparing the product: adding the grafting particles into 300-500mg / L phenylethanolamine A aqueous solution, adjusting the pH value of the system to be alkaline, adding a crosslinking agent and heating for reaction; after the reaction is finished, washing off template molecule phenylethanolamine A, drying and obtaining the phenylethanolamine A surface molecularly-imprinted material. Compared with the prior art, the preparation method has the advantages that the preparation process is simple, the operability is strong, and the preparation cost is low; and the molecularly-imprinted material is good in specificity, short in adsorption equilibrium time of phenylethanolamine A, short in elution time and good in elution effect.
Owner:NINGBO ACAD OF AGRI SCI
Hydrophobic paper SERS substrate, preparation method thereof and application thereof
The invention discloses a hydrophobic paper SERS substrate, a preparation method thereof and an application thereof. The natural wrinkles and a small pore diameter of filter paper allow the depositionand arrangement of metal nano particles on paper to form a large-area SERS hot spot. A composite paper-based substrate is formed by reducing and preparing a cellulose nanocrystals-silver (CNC-Ag) composite on the filter paper. Pores in the surface of the filter paper are further filled with a CNC-Ag composite material, and the reproducibility of an SERS sensor is improved. The paper-based substrate is modified with hydrophobic alkyl mercaptan, the modified substrate has a cohesive effect for a sample to be tested, and therefore, the limit of detection of an analyte is improved. That two substances including phenylethanolamine A and metronidazole can be effectively detected by the paper-based SERS substrate is proved, and the limit of detection (LOD) is as low as 5* 10(-9) mol / L and 2*10(-7) mol / L.
Owner:FUJIAN NORMAL UNIV
Novel optical activity phenylethanolamine compounds and preparation method thereof
A Icompound with (-) or (+) structure or its medicinal salt, composition containing the compound and the production of the compound are disclosed. R 1 is H or halogen; R2 is CF3, CN or halogen; R3 is C1-6 straight chain or branched chain alkyl radical or C3-6 naphthene. It has beta-2 acceptor excitation function and can be used to treat asthma or bronchitis.
Owner:SHENYANG PHARMA UNIV BENXI PHARMA SCI & TECH
Method of detecting content of phenylethanolamine A and detection kit
ActiveCN103265440AHigh sensitivityStrong specificityOrganic compound preparationOvalbuminPig liverImmune profiling
The invention discloses a method of detecting a content of phenylethanolamine A and a detection kit. According to the method, immunogens and coating antigens are prepared by synthesizing hapten derivatives of the phenylethanolamine A and crosslinking the derivatives with carrier proteins. Four kinds of polyclonal antibodies of rabbit anti-phenylethanolamine A through immunizing animals are obtained and all the four antibodies can be used for immunoassay of the phenylethanolamine A. The invention further provides an ELISA detection kit containing the antigens and / or antibodies. The ELISA method built by the invention is high in sensitivity and strong in specificity. Four kinds of samples: pig kidney, pig liver, pork and pig forage, are added with different amounts of the phenylethanolamine A for an addition and reclamation test, and the test shows that the detecting method provided by the invention is accurate, and has relatively good correlation with an LC-MS-MS method.
Owner:SUZHOU UNIV
Five-conjugate testing card for detecting beta-stimulant drugs and preparation method thereof
The invention relates to a five-conjugate testing card for detecting beta-stimulant drugs and a preparation method thereof and belongs to the technical field of beta-adrenergic receptor stimulant detection. A test strip is arranged in a casing of the testing card which is composed of a polyvinyl chloride (PVC) glue board, a sample pad, a colloidal gold combination pad, a coated film and absorbent cotton. A colloidal gold film is a glass cellulose film which contains colloidal gold markers of a clenbuterol monoclonal antibody, a ractopamine monoclonal antibody, a salbutamol monoclonal antibody, a phenylethanolamine A monoclonal antibody and a terbutaline monoclonal antibody. The coated film is a nitrocellulose film, wherein five detection lines T and a quality control line C are arranged on the coated film, and the quality control line C is coated with a rabbit anti-mouse immunoglobulin G (IgG) antibody. The five-conjugate testing card can simultaneously detect out clenbuterol, ractopamine, salbutamol, phenylethanolamine A and terbutaline, and is simple, convenient and fast in method, and accurate in result.
Owner:JIANGSU WISE SCI & TECH DEV
High-temperature curing agent for phenolic resin in fields of casting and 3D (Three Dimensional) ink-jet printing
ActiveCN108907068AImprove room temperature strengthImprove high temperature resistanceFoundry mouldsFoundry coresStrong acidsTemperature resistance
The invention discloses a high-temperature curing agent for phenolic resin in the fields of casting and 3D (Three Dimensional) ink-jet printing. The high-temperature curing agent for the phenolic resin is a strong-acid liquid material, the pH (Potential of Hydrogen) value of the high-temperature curing agent is smaller than 2, the content of free acid is 15 to 30 percent, and the total acidity is20 to 45 percent; the high-temperature curing agent for the phenolic resin is prepared from the following components: inorganic acid, inorganic acid salt, anhydride, urea, phenylethanolamine and othercompounds. Although common phenolic resin for casting is capable of realizing normal-temperature rapid curing and forming, both the common phenolic resin and the phenolic resin are in larger viscosity, and the specific requirements of casting and 3D ink-jet printing technologies on resin viscosity cannot be met. In order to overcome the defects of the prior art, the high-temperature curing agentfor the phenolic resin in the fields of casting and 3D ink-jet printing is successfully invented through technical innovation; casting sand formed through cross-linking and curing of the high-temperature curing agent and thermoset A-stage phenolic resin under a high-temperature condition has the advantages of high normal-temperature strength, excellent high temperature resistance, good scatteringperformance and the like.
Owner:NINGXIA KOCEL MOLD
Chloride-free railway transportation coal antifreezing agent
InactiveCN110028933AGood antifreezeGood wall hanging effectOther chemical processesGlycerolPolyethylene glycol
The invention discloses a chloride-free railway transportation coal antifreezing agent, and belongs to the technical field of coal antifreezing agents. The chloride-free railway transportation coal antifreezing agent comprises 20-28% of sodium formate, 5-15% of glycerol, 8-10% of urea, 7-8% of sodium nitrite, 2-3% of sodium carbonate, 2-3% of triethanolamine borate, 1-2% of phenylethanolamine, 1-2% of polyethylene glycol, 0.1-1% of benzotriazole, and 40-50% of water. The antifreezing performance is excellent, the freezing point is lower than minus 30 DEG C, the wall hanging effect is good, theadhesiveness is good, the viscosity is moderate, the chloride-free railway transportation coal antifreezing agent is convenient to spray, contains no chloride, meets the requirement on chloride content of export coal, and is nonirritant to and has no harmful effect on the skin of an operation staff.
Owner:CCTEG CHINA COAL RES INST
Phenylethanolamine A hapten, antigen as well as preparation method and application thereof
InactiveCN105272866AHigh yieldThe preparation method is simple and feasibleOrganic compound preparationOvalbuminElisa kitCarrier protein
The invention discloses a phenylethanolamine A hapten, a related artificial antigen and a monoclonal antibody; the invention simultaneously discloses preparation methods and applications of the phenylethanolamine A hapten, the related artificial antigen and the monoclonal antibody. The phenylethanolamine A hapten is the product shown in the formula 1, and the product shown in the formula 1 and a carrier protein can be connected to obtain a phenylethanolamine A antigen. The phenylethanolamine A antigen can be used for preparing a phenylethanolamine A specific antibody. The preparation methods have the advantages of simple and practicable operation, low cost and high yield of the hapten. The phenylethanolamine A artificial antigen can be used for producing the specific antibody aiming at the phenylethanolamine A by immune animals, and can be used for preparing an ELISA kit for detecting phenylethanolamine A residuals; the kit has the advantages of simple and rapid operation, large sample treatment amount, high sensitivity, good specificity, etc.
Owner:北京维德维康生物技术有限公司
Detection method and detection sensor for phenylethanolamine A on the basis of composite membrane modification electrode
PendingCN110133077AGood dispersionImprove conductivityNanosensorsMaterial electrochemical variablesMagnetite NanoparticlesPeak current
The invention discloses a detection method and a detection sensor for phenylethanolamine A (PEA-A) on the basis of a composite membrane modification electrode. The method comprises the following stepsthat: preparing Fe3O4@SiO2 magnetic nanoparticles, preparing AB-GO (Acetylene Black-Graphene Oxide) composite nanomaterials, preparing an Fe3O4@SiO2 / AB-GO / GCE (Glassy Carbon Electrode) composite membrane modification electrode, carrying out phenylethanolamine A detection and the like. A result indicates that the Fe3O4@SiO2 / AB-GO / GCE has a good electrocatalytic oxidation and reduction characteristic on the PEA-A. In 0.10mol / L of PBS (poly(butylene succinate)) buffer solution (pH=6), the response peak current of the modification electrode and the concentration of PEA-A have a good linear relationship, a linear range is 1.0-1000nmol / L, and a detection limit is 0.12nmol / L(S / N=3). The electrode has good reproducibility, stability and antijamming capability. The electrode is used for measuringthe PEA-A in porcine serum and porcine urine samples, and recovery rates are independently 96.0-110.0% and 93.8-104.7%. The electrode is shown to have an important application value in the field of healthful aquaculture biochemical detection.
Owner:CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Phenylethanolamine A magnetic molecular imprinted polymer microsphere as well as preparation method and application thereof
InactiveCN103539884AAvoid reunionPrevent oxidationIon-exchange process apparatusOther chemical processesMicrosphereUltraviolet absorption
The invention discloses a phenylethanolamine A magnetic molecular imprinted polymer microsphere as well as a preparation method and application thereof. The method comprises the following steps: mixing phenylethanolamine A and methacrylic acid, and then pre-polymerizing; adding surface aminated Fe3O4 magnetic nanoparticles, divinyl benzene and 2, 2'-azodiisobutyronitrile into a system after prepolymerization for polymerization reaction; collecting polymers obtained after the polymerization reaction by a magnet, and washing the polymers with acetic acetonitrile liquor, wherein when the cleaning liquid does not have the absorption peak of phenylethanolamine A under ultraviolet detection, the microsphere is obtained, and the ultraviolet absorption peak of phenylethanolamine A in the ultraviolet-visible absorption spectrum is 278nm. According to the invention, a molecular imprinted polymer is combined with Fe3O4, thereby not only effectively preventing Fe3O4 magnetic nanoparticles from being agglomerated and oxidized, but also selectively identifying template molecules as well as analogues thereof by means of cavities in the molecular imprinted polymer which are matched with the steric configuration of the template molecules and have multiple acting points. Therefore, the microsphere has better including and complexing capacity and chemical stability.
Owner:INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
Polyanhydrides with therapeutically useful degradation products
InactiveUS20070213500A1Promote degradationEasy to processCosmetic preparationsPowder deliveryTissue reconstructionPolyanhydrides
An aromatic polyanhydride comprising a repeating unit having the structure is disclosed, wherein Ar and R are selected so that the aromatic polyanhydride hydrolyzes to form a therapeutic salicylate, another non-steroidal anti-inflammatory, an antifibrotic aminobenzoate, or a vasoconstricting phenylethanolamine. Implantable medical devices, such as scaffolding implants for tissue reconstruction, drug delivery systems prepared from the aromatic polyanhydrides, as well as therapeutic dosage forms and treatment methods are also disclosed.
Owner:XENOGENICS
Method for preparing phenylethanolamine compound intermediate
InactiveCN107963976AEasy to removeEasy to operateComponent separationOrganic compound preparationBenzene3-phenylpropylamine
The invention discloses a method for preparing a phenylethanolamine compound intermediate. The method comprises the following steps: (1) carrying out a nitrifying reaction on 1-methyl-3-phenylpropylamine and a nitrifying reagent to obtain a 4-(4-nitrophenyl)-butan-2-amine and 4-(2-nitrophenyl)-butan-2-amine mixture; and (2) reacting the mixture obtained in step (1) with a compound of formula III,and separating the obtained reaction product to obtain the phenylethanolamine compound intermediate of formula I. The method for preparing the phenylethanolamine compound intermediate has the advantages of simplicity in operation, short route and few steps; and an o-nitro impurities generated in the nitrifying reaction can be easily removed after being reacted without separation and becoming corresponding amides, so the reaction yield and the product purity are high, and the industrial production of the product is facilitated.
Owner:CHINA ANIMAL DISEASE CONTROL CENT
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