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Phenylethanolamine A molecularly imprinted membrane, preparation method thereof and applications thereof

A molecularly imprinted membrane and phenylethanolamine technology, applied in chemical instruments and methods, membrane technology, ion exchange, etc., can solve the problems of poor selectivity and large sample matrix interference, and achieve the effect of regular shape

Inactive Publication Date: 2014-02-26
INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purification material in sample pretreatment is mainly mixed cation solid phase extraction, but its selectivity is poor
Especially in the detection process of liquid chromatography-tandem mass spectrometry, the sample matrix interferes a lot

Method used

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  • Phenylethanolamine A molecularly imprinted membrane, preparation method thereof and applications thereof
  • Phenylethanolamine A molecularly imprinted membrane, preparation method thereof and applications thereof
  • Phenylethanolamine A molecularly imprinted membrane, preparation method thereof and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1, preparation of phenylethanolamine A molecularly imprinted membrane

[0033] (1) Surface modification and activation of PVDF membrane

[0034] Surface modification of PVDF membrane: immerse PVDF membrane in 3wt% NaOH aqueous solution at 60°C for 12 hours, absorb excess aqueous solution on the surface, then immerse in 10wt% acrylic acid and 1wt% initiator potassium persulfate in aqueous solution, and pass through nitrogen After deoxygenation, react at a constant temperature of 70°C for 5h.

[0035] Activation of the surface-modified PVDF membrane: first soak the treated PVDF membrane in ultrapure water for 1 hour, take it out and immerse it in acetonitrile for 0.5 hours, then soak it in 0.15mol / L fresh AIBN acetonitrile solution for 20 minutes, take it out and evaporate it Dry acetonitrile was immediately immersed in the molecular imprinting mix solution in the following steps.

[0036] (2) Preparation of phenylethanolamine A molecularly imprinted membrane...

Embodiment 2

[0038] Example 2, Optimization of the preparation method of phenylethanolamine A molecularly imprinted membrane

[0039] The phenylethanolamine A molecularly imprinted membrane was prepared according to the steps in Example 1, wherein the ratio of the template molecule phenylethanolamine A, the monomer MAA, the cross-linking agent EGDMA and the initiator AIBN is shown in Table 1.

[0040] The concentration of the standard phenylethanolamine A acetonitrile solution used in the adsorption test was 5mg / L, 250ml was adsorbed, and 1ml was eluted. Each data was measured in parallel three times, and the RSD was less than or equal to 5.5%. Through the comparison of the adsorption amount of phenylethanolamine A between different ratios and imprinted and non-imprinted materials, the mass ratio between the three finally selected was 1:6:30.

[0041] Table 1 Selection of molecularly imprinted membrane synthesis ratio

[0042]

Embodiment 3

[0043] The characterization of the phenylethanolamine A molecularly imprinted membrane prepared in embodiment 3 and embodiment 1

[0044] (1) Thermogravimetric analysis

[0045] In order to determine the modification effect on the surface of PVDF membrane, the modified (surface modification and activated PVDF membrane prepared in Example 1) and unmodified PVDF membrane were characterized by thermogravimetric analysis, the results are as follows figure 2 shown. From figure 2 It can be seen that the relationship between the percentage of mass retention and temperature is obtained through thermogravimetric experiments. The grafted PVDF membrane begins to lose weight before the ungrafted PVDF membrane, and the weight loss temperature of the grafted PVDF membrane is lower than that of the ungrafted PVDF membrane. PVDF membrane. Due to the characteristics of heat resistance and good stability of PVDF membrane, the weight loss temperature of ungrafted PVDF membrane is higher tha...

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Abstract

The invention discloses a phenylethanolamine A molecularly imprinted membrane and a preparation method thereof. The method comprises steps of performing prepolymerization after phenylethanolamine A and methacrylic acid are mixed; adding ethylene glycol dimethacrylate and 2,2'-azodiisobutyronitrile into the system after prepolymerization to obtain a polymerization system; dipping a PVDF membrane in the polymerization system; subjecting the dipped PVDF membrane to a polymerization reaction in a nitrogen environment; and washing the PVDF membrane with methanol after the polymerization reaction is finished. Beneficial effects of the phenylethanolamine A molecularly imprinted membrane and the preparation method are that: the phenylethanolamine A molecularly imprinted membrane has advantages both of molecular imprinting technology and membrane separation technology; and the advantages comprise that (1) specific space sites and functional groups in the phenylethanolamine A molecularly imprinted membrane can achieve specific recognition of an object to be detected, and (2) compared with traditional molecularly imprinted microsphere materials, the molecularly imprinted membrane material provided by the invention is more stable, and more ordered in form, and can be used directly without tedious preparation processes such as a column packing process, etc..

Description

technical field [0001] The invention relates to a phenylethanolamine A molecularly imprinted membrane, a preparation method and application thereof. Background technique [0002] Phenylolamine A is a synthetic chemical substance. Clonpamine is an isomer of formoterol, which is a by-product of the synthesis of ractopamine by Eli Lilly and Company of the United States. It has the same action and effect as clenbuterol and ractopamine, and is a kind of β2 agonist , with nutrient redistribution. Molecular formula is C 19 h 24 N 2 o 4 , the chemical structural formula is 2-[4-(4-nitrophenyl)butyl-2-hydroxylamino]-1-methoxyphenethyl alcohol. From 2009 to 2010, criminals sold a product called Clonbamine (Clonbamine), promoting it as a natural active substance, which can improve the immunity and resistance of pigs, promote growth speed, and improve the quality of pigs. Benefits, and there are no doping positives and false positives in the drug test. Afterwards, it was identif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30B01D71/34B01D69/10B01D67/00B01D15/08
Inventor 王培龙苏晓鸥朱若华刘曦朦
Owner INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
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