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Amoxicillin pharmaceutical preparation and preparation method thereof

A technology for amoxicillin and preparations, applied in the field of pharmaceutical preparations, can solve problems such as toxic and side effects, and achieve the effects of good stability, simple prescription composition, and reduced production costs

Active Publication Date: 2018-04-06
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are as many as three kinds of auxiliary materials used in the prescription, and the surfactant sodium lauryl sulfate added therein has certain toxic and side effects on the human body.

Method used

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  • Amoxicillin pharmaceutical preparation and preparation method thereof
  • Amoxicillin pharmaceutical preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 Amoxicillin capsule and preparation method thereof

[0024] Amoxicillin 245g

[0025] Magnesium stearate 5g

[0026] The amoxicillin raw material whose particle size distribution of the above prescription amount is D102.56 μm, D507.8 μm, D9020.2 μm is air-dried and added to a dry press for granulation. Vibrating sieve and sieve to get amoxicillin heavy powder granules; the particle size distribution of the above prescription is D104.2 μm, D5015.7 μm, D903.8 μm magnesium stearate is pulverized and sieved with a rotary vibrating sieve, and mixed with amoxicillin Put the Xilin heavy powder granules together into the powder mixer and mix evenly; fill the mixed medicinal powder into capsules with a capsule filling machine to make 1000 capsules, and the product is ready.

Embodiment 2

[0027] Embodiment 2 Amoxicillin capsules and preparation method thereof

[0028] Amoxicillin 225g

[0029] Magnesium Stearate 25g

[0030] The amoxicillin raw material with the particle size distribution of the above prescription amount as D105.5 μm, D5013.7 μm, D9033.1 μm was air-dried and added to a dry press for granulation. The pressure was adjusted to 1100 bar. Vibrating sieve and sieve to get amoxicillin heavy powder granules; the particle size distribution of the above prescription is D106.1 μm, D5020.4 μm, D9049.7 μm magnesium stearate is pulverized and sieved with a rotary vibrating sieve, and mixed with amoxicillin Put the Xilin heavy powder granules together into the powder mixer and mix evenly; fill the mixed medicinal powder into capsules with a capsule filling machine to make 1000 capsules, and the product is ready.

Embodiment 3

[0031] Embodiment 3 Amoxicillin capsules and preparation method thereof

[0032] Amoxicillin 247.5g

[0033] Magnesium Stearate 2.5g

[0034] The amoxicillin raw material with the particle size distribution of the above prescription amount as D106.8 μm, D5017.0 μm, D9044.7 μm was air-dried and added to a dry press for granulation. The pressure was adjusted to 150 bar. Vibrating sieve and sieve to get amoxicillin heavy powder granules; the particle size distribution of the above prescription is D1012.5 μm, D5023.3 μm, D9043.3 μm magnesium stearate is pulverized and sieved with a rotary vibrating sieve, and mixed with amoxicillin Put the Xilin heavy powder granules together into the powder mixer and mix evenly; fill the mixed medicinal powder into capsules with a capsule filling machine to make 1000 capsules, and the product is ready.

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PUM

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Abstract

The invention discloses an amoxicillin pharmaceutical preparation and a preparation method thereof. The amoxicillin pharmaceutical preparation comprises the following components in parts by mass: 90.0-99.9 parts of amoxicillin and 0.1-10.0 parts of magnesium stearate. The preparation method is a dry-press process. By controlling the particle size distribution of amoxicillin, the particle size distribution of magnesium stearate and the pressure of the dry press, excellent dissolution quantity and stability of the amoxicillin preparation can be ensured.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular, the invention relates to amoxicillin capsules and a preparation method thereof. Background technique [0002] Amoxicillin is a broad-spectrum antibiotic. It exerts a bactericidal effect by inhibiting the synthesis of bacterial cell walls. It can quickly dissolve and rupture bacteria into spheroids. It has a strong and rapid killing effect on both Gram-negative bacteria and positive bacteria. Terminal spirochetes also have a killing effect. As the β-lactam oral antibiotic preferred by WHO, amoxicillin has good effects on infections of the respiratory system, urinary system, and digestive system. Oral dosage forms of amoxicillin include tablets, capsules, granules, dispersible tablets, etc. Among them, amoxicillin capsules are commonly used in clinical practice and are listed as a category A variety of national medical insurance. [0003] However, amoxicillin has poor sol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/43A61K47/12A61P31/04
CPCA61K9/4858A61K31/43
Inventor 邢盛王健松王玮陈红英张信周裴泽健朱少璇邓淑渊
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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