Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Compound capsule and preparation method thereof

A capsule and compound technology, applied in the field of compound capsules and its preparation, can solve the problems of slow onset of action and large adverse reactions, and achieve the effect of short preparation steps, no special equipment requirements, and significant peptic ulcer

Inactive Publication Date: 2011-06-15
王勇
View PDF3 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the adverse reactions are large and the onset is slow

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound capsule and preparation method thereof
  • Compound capsule and preparation method thereof
  • Compound capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0034] The preparation of lansoprazole enteric-coated pellets is carried out in a fluidized bed granulation coating machine. The preparation process is coating of the main drug layer, coating of the isolation layer, coating of the neutral layer, and coating of the enteric layer;

[0035] Among them, 1) The specific operation of coating the main drug layer is as follows:

[0036] Take 20-40mL of purified water, stir, and slowly add 0.2-0.4g of anhydrous sodium carbonate as an acid-base regulator. -0.4 g polysorbate-80 is used as a solubilizer, and after dissolving completely, add lansoprazole in the dark, and stir into a uniform suspension; the blank ball core is placed in a fluidized bed granulation coating machine, and the boiling air volume 20-40 Hz, jet pressure 0.1-0.3 MPa, material temperature 35-40 ℃, spray speed 2.0-4.0 mL min -1 , the main drug layer coating pellet containing lansoprazole 20-40% is obtained;

[0037] 2) The specific operation of the isolation layer c...

Embodiment 1

[0057] A compound capsule is composed of lansoprazole enteric-coated pellets, clarithromycin gastric-soluble pellets and amoxicillin gastric-soluble pellets, twice a day, each dosage is: lansoprazole 30mg, clarithromycin 500mg, amoxicillin 1000mg.

[0058] The preparation of lansoprazole enteric-coated pellets is carried out in a fluidized bed granulation coating machine. The preparation process is coating of the main drug layer, coating of the isolation layer, coating of the neutral layer, and coating of the enteric layer;

[0059] Among them, 1) The specific operation of coating the main drug layer is as follows:

[0060] Take 30mL of purified water, under stirring, slowly add 0.3g of anhydrous sodium carbonate as an acid-base regulator, sequentially add 1.5g of hydroxypropyl methylcellulose, 0.3g of polysorbate-80 as a solubilizer, and add Lansol in the dark Prazole, stirred into a uniform suspension; put the blank pellet core in a fluidized bed granulation coating machine...

Embodiment 2

[0081] A compound capsule is composed of lansoprazole enteric-coated pellets, clarithromycin gastric-soluble pellets and amoxicillin gastric-soluble pellets, twice a day, each dosage is: lansoprazole 20mg, clarithromycin 400mg, amoxicillin 900mg.

[0082] The preparation of lansoprazole enteric-coated pellets is carried out in a fluidized bed granulation coating machine. The preparation process is coating of the main drug layer, coating of the isolation layer, coating of the neutral layer, and coating of the enteric layer;

[0083] Among them, 1) The specific operation of coating the main drug layer is as follows:

[0084] Take 20 mL of purified water, add 0.4 g of anhydrous sodium carbonate, add 1.0 hydroxypropyl methylcellulose in turn, add 0.4 g of polysorbate-80, add lansoprazole in the dark, stir to form a uniform suspension; boil Air volume 20 Hz, jet pressure 0.3 MPa, material temperature 40 ℃, spray speed 2.0mL min -1 , made the main drug layer coating pellet contain...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a compound capsule and a preparation method thereof. The capsule comprises lansoprazole enteric coated pellets, clarithromycin stomach-soluble pellets and amoxicillin stomach-soluble pellets. The compound capsule is administered twice one day based on the following dose each time: lansoprazole 20-40 mg, clarithromycin 400-600 mg, and amoxicillin 900-1100 mg. The capsule provided by the invention has a distinct effect on peptic ulcer, is used for thoroughly killing helicobacter pylori, and has the advantages of quick action, strong effect, improved bioavailability, convenience in administration and low cost.

Description

technical field [0001] The invention belongs to the field of pharmacy, and more specifically relates to a compound capsule and a preparation method thereof. Background technique [0002] Peptic ulcer (peptic ulcer) is one of clinically common and frequently-occurring diseases. my country is an area with a high incidence of ulcers, and according to statistics, about 10% of the population has suffered from this disease in their lifetime. Clinically, duodenal ulcer is more common than gastric ulcer, and the ratio of the two is about 1.56-5.6:1. Gastric ulcer and duodenal ulcer are chronic diseases with high recurrence coefficient, and require long-term treatment, especially for patients with gastric ulcer and duodenal ulcer caused by Helicobacter pylori infection. For patients, the price factor of medicines is very important. Therefore, the majority of patients urgently need products with good curative effect, high safety, low price, small adverse effects, good durability, a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/4439A61K31/43A61K9/48A61K9/34A61K9/16A61P1/04A61P31/04
Inventor 王勇
Owner 王勇
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com