153 results about "Fluidized bed granulation" patented technology

The invention discloses a large-scale continuous energy-saving fluidized bed spray granulation drying process, which belongs to the granulation drying technology. The surface of the seed crystal particles in the granulation fluidized bed is dried under the combined heating of the hot air and the built-in heater. The discharged materials are first screened out of lumps and oversized particles, and then sent to the cooling fluidized bed After the discharged materials are screened, the materials larger than the qualified particle size are crushed by the crusher, and then returned to the granulation fluidized bed together with the material smaller than the qualified particle size as crystal seeds for re-granulation, and the qualified particle size is sent to the into the finished product silo. The invention has strong material adaptability, can obtain granular products with large specific gravity, high strength, good sphericity, uniform particle size, and is not easy to absorb moisture, and realizes continuous large-scale production. Pollution and other characteristics.

A preparation method of a Levamlodipine besylate tablet includes pulverizing Levamlodipine besylate, a filler and a disintegrant, sieving, mixing, adding a lubricant, granulating, and tableting. The invention reduces the amount of related substance of the Levamlodipine besylate tablet, and improves stability. The method uses a fluidized bed granulation step to prepare the Levamlodipine besylate tablet, so as to simplify preparation step, shorten time, optimize process parameter, significantly increase the dissolution of the product and improve quality. The inventive method is suitable for industrial production.

Fluid bed granulation process comprising the step of cooling the granules in a cooling fluid bed (F2). At least part of the fluidizing air coming out from said cooling fluid bed (F2) is fed into the granulation fluid bed (F1).

The invention belongs to the technical field of medicinal preparations and in particular relates to readily soluble tenofovir disoproxil fumarate tablets and a preparation method thereof. The readily soluble tenofovir disoproxil fumarate tablets are prepared by taking tenofovir disoproxil fumarate as a raw material and a pharmaceutically acceptable auxiliary component as an auxiliary material, and adopting a fluidized bed granulation tabletting process and a wet activity dry granulation tabletting process, wherein the auxiliary material comprises microcrystalline cellulose, pregelatinized starch, lactose, crosslinking carboxymethyl cellulose sodium, Cellactose 80 and magnesium stearate. The readily soluble tenofovir disoproxil fumarate tablets provided by the invention have the advantages of relatively good intermediate fluidity, mellow and full granules, uniform size, high dissolution rate and the like, and can obviously improve the dissolution rate of a medicament in water, and by virtue of significantly improving the dissolution rate of the medicament, the biological utilization degree of an oral administration medicament is improved.

The invention provides a pharmaceutical composition containing vildagliptin and metformin. In the pharmaceutical composition, vildagliptin is good in content uniformity, high in dissolution rate and stable in product. A preparation method of the pharmaceutical composition comprises the steps that metformin hydrochloride and an adhesive are prepared into granules through a fluidized bed granulation technology; the granules, vildagliptin and a filler are mixed to be uniform, and then dry granulation is conducted; the mixture is mixed with a lubricant, and tablets are prepared. By means of the fluidized bed granulation technology, the fluidity and compressibility of metformin hydrochloride are greatly improved, the granularity of vildagliptin is controlled to be within a certain range, direction contact of metformin hydrochloride and vildagliptin is reduced, and degradation of vildagliptin is reduced; by means of dry granulation, the content uniformity, a tablet weight difference and the like of the granules all meet the requirements. By means of the preparation process, compound preparations with small differences between batches can be obtained, the friability, content uniformity and stability of the tablets all meet the requirements, and the pharmaceutical composition can be subjected to scale-up production in a workshop.

The invention disclose montelukast sodium granules and a preparation method thereof, and relates to the field of a montelukast sodium preparation. The montelukast sodium granules provided by the invention are prepared from a raw material by dry granulation or fluidized bed granulation; the raw material comprises the following components in percentage by weight: 0.5% to 1.5% of montelukast sodium,35% to 65% of mannitol, 15% to 45% of lactose anhydrous, 10 to 30% of microcrystalline cellulose, 0% to 20% of adhesive used when a fluidized bed is adopted to carry out granulation, 0.5% to 3.5% of corrigent and 0.5% to 5% of lubricant. The montelukast sodium granules not only have the characteristics of rapid absorption, good dissoluvability, rapid response, convenience and comfort for taking, good taste and the like, but also have excellent stability.

The invention discloses a linagliptin active component-containing composition and a preparation method thereof. The composition contains the active component linagliptin, and also comprises the following auxiliary materials, by weight, 80-150 parts of mannitol, 10-60 parts of pregelatinized starch, 1-30 parts of corn starch, 1-10 parts of polyvinylpyrrolidone and 1-5 parts of magnesium stearate. Fluidized bed granulation integrates mixing, granulation and drying, so the bare link in the granulation process is reduced, and the operation is simple and controllable. Linagliptin is added in a suspending injection manner, so uniform mixing of linagliptin is facilitated.

Process for fluidized bed granulation of amino acid-containing fermentation broths comprising the stepsIntroduction of a drying gas with a temperature of 100° C.-450° C. into the fluidized bed granulation chamberSpraying of the amino acid-containing fermentation broth into the fluidized bed granulation chamberDischarge of the granules granulated in the fluidized bed granulation chamber with the drying gas stream, anddrying of the discharged granules in a fluidized bed drying step,wherein the discharged granulated granules are a granule mixture with various particle sizes and contains an oversize fraction, wherein the oversize comprises the particle sizes which lie above a desired particle size, an wherein the oversize fraction is removed from the discharged granule mixture and then comminuted and the comminuted oversize and the granule mixture from which the oversize was separated are fed into the fluidized bed drying step.