167 results about "Crospovidones" patented technology

The present invention provides a chemically stable pharmaceutical preparation of a benzimidazole type compound. That is, the present invention relates to a composition comprising at least one substance selected from sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, aminoalkyl methaacrylate copolymer E, arginine aspartate, hydroxypropyl cellulose and crospovidone incorporated into a benzimidazole type compound or an alkali metal salt thereof.

Solid pharmaceutical compositions suitable for the oral delivery of pharmacologically active agents, e.g. peptides, comprising a therapeutically-effective amount of a pharmacologically active agent; a crospovidone or povidone; and a delivery agent for said pharmacologically active agent are disclosed. The compositions provide excellent oral bioavailability of pharmacologically active agents, particularly calcitonin.

The invention relates to a lansoprazole crystalline compound. An X-ray powder diffraction pattern represented by a diffraction angle of 2 theta +/- 0.2 DEG displays feature diffraction peaks at the positions of 5.8 DEG, 7.5 DEG, 9.1 DEG, 11.8 DEG, 12.1 DEG, 12.8 DEG, 13.3 DEG, 15.6 DEG, 16.7 DEG, 18.3 DEG, 20.4 DEG, 25.7 DEG, 26.8 DEG and 31.5 DEG. The invention also relates to a lansoprazole enteric capsule containing the lansoprazole crystalline compound. The lansoprazole enteric capsule comprises 20 to 60 parts of l crystalline compound, 90 to 140 parts of microcrystalline cellulose, 1.5 to 3.5 parts of disodium hydrogen phosphate, 2 to 5 parts of anhydrous sodium sulphite, 1 to 10 parts of crospovidone, 0.8 to 4.2 parts of lauryl sodium sulfate, 2 to 8 parts of povidone K30 and 1 to 3 parts of magnesium stearate.

The invention discloses a sevelamer carbonate medical tablet composition and a preparation method thereof. The tablet composition comprises the following components in parts by weight: 60-95 parts of sevelamer carbonate, 5-30 parts of crospovidone and 0.1-10.0 parts of silicon dioxide. The preparation method of the tablet composition comprises the following steps: a. sevelamer carbonate is mixed with crospovidone; b. the mixture obtained in step a is pelletized; c. silicon dioxide is mixed with the particles produced in step b to form tablets; d. the tablets obtained is film-coated by water-soluble coating materials. The tablet composition provided by the invention is characterized in that the formability is good, the rigidity is high, the disintegration is quick, and the disintegration is less affected by the rigidity.

The invention relates to spirulina tablets and a preparation method thereof. The spirulina tablets comprise the following raw materials in percentage by weight: 60-85 percent of spirulina powder, 5-15 percent of crospovidone, 0.5-3 percent of acrylic resin No. III, 1-3.5 percent of silicon dioxide, 0.4-0.6 percent of magnesium stearate, 5-12 percent of aerosol, and 3-6 percent of microcrystallinecellulose. The method comprises the steps of: evenly mixing the spirulina powder and the crospovidone through an 80-mesh sieve, granulating by using the ethanol solution of the acrylic resin No. III in percentage concentration, drying granules, adding 1-3.5% of the silicon dioxide, the magnesium stearate, the aerosol and the microcrystalline cellulose, evenly mixing and then tabletting. The invention greatly improves the metabolism and absorptivity of the spirulina tablets in vivo, greatly improves the disintegration absorption of the spirulina (because non-functional components of a binder, such as starch and the like, are not added in a tabletting process) compared with the traditional tablets, and benefits the gastrointestinal digestion, and high absorption rate and high bioavailability are achieved.

The invention relates to a capsule containing valsartan and amlodipine besylate, which is prepared from high-dose valsartan and amlodipine besylate, disintegrating agent crospovidone, filling agent microcrystalline cellulose and lubricating agent silicondioxide. The problem that the compound preparation contianing a high dose of valsartan and amlodipine besylate is not easy to disintegrate and dissolve is solved by adopting the conventional process and equipment of powder mixing and direct capsule filling without using special equipment and the bilayer tablet process.

The present invention provides a method for stabilizing an oral solid formulation containing a benzimidazole-based compound or a physiologically acceptable salt thereof. That is, it provides a method for stabilizing a benzimidazole-based compound or a physiologically acceptable salt thereof, comprising incorporating 1) a crospovidone or a crospovidone and 2) sodium hydroxide and/or potassium hydroxide to a benzimidazole-based compound or a physiologically acceptable salt thereof.

The invention provides an afatinib dimaleate tablet and a preparation method thereof. The afatinib dimaleate tablet is composed of a table core and a film coating wrapping the exterior of the table core and prepared by taking lactose monohydrate and microcrystalline cellulose PH301 as filling agents, taking crospovidone as a disintegrating agent, taking silicon dioxide as a flow aid and taking magnesium stearate as a lubricating agent. The preparation method has the advantages that the tablet is prepared by adopting a dry granulation technique, the fluidity can be improved, separation of all the components can be prevented to avoid the condition that the tablet components are not uniform, the bulk density is regulated, and the dissolving property and uniform pressure transmission in tablet production are improved.

An oral disintegrating tablet containing (1) D-mannitol, (2) an active ingredient, (3) one or more disintegrating agents selected from the group consisting of crospovidone and carmellose, and (4) one or more lubricants selected from the group consisting of sodium stearyl fumarate and sucrose esters of fatty acids. The oral disintegrating tablet of the present invention has some excellent properties of (1) allowing easy production in a common facility without necessitating a specialized pharmaceutical technique, (2) having an appropriate strength that does not breakdown in the process of distribution, (3) having a fast disintegrating ability in the oral cavity, and (4) also having excellent ingestion feel such as greatly reduced bitterness or gritty feel; therefore, the tablet can be suitably used as a dosage form that is suitable for aged individuals, children, and seriously ill patients.

Provided herein are compositions and methods of making compositions of ibuprofen in combination with a narcotic analgesic. Specifically provided is a pharmaceutical tablet composition comprising ibuprofen; a narcotic analgesic; colloidal silicon dioxide; a filler selected from the group consisting of microcrystalline cellulose and powdered cellulose; a disintegrant selected from the group consisting of croscarmellose sodium, crospovidone, and sodium starch glycolate; a binder consisting of an akylhydroxy methylcellulose; a starch; and a lubricant. Also provided herein is a method of preparing a pharmaceutical tablet composition comprising: (a) Granulating ibuprofen, a narcotic analgesic, a first glidant, a first disintegrant, a binder, and starch to form granules wherein said granulating step comprises a wet granulation process; (b) blending the granules with extra-granular material comprised of a second glidant, a second disintegrant, a filler and starch to form a blend of granules and extra-granular material; and (c) compressing the blend into a tablet.

The invention discloses an aprepitant oral pharmaceutical preparation. The aprepitant oral pharmaceutical preparation comprises 15wt%-25wt% of aprepitant, 45wt%-75wt% of hydroxypropyl methylcellulose phthalate/hydroxypropyl methylcellulose acetate succinate, 10wt%-25wt% of microcrystalline cellulose, lactose or mannitol, 2wt%-8wt% of low-substituted hydroxypropyl cellulose as well as croscarmellose sodium and/or crospovidone, 0-2wt% of silicon dioxide and/or talc and 0-2wt% of magnesium stearate. The pharmaceutical preparation can be prepared in a form of tablets or capsules andhas high stability and good bioavailability.

The invention discloses a waterborne anti-sticking agent applicable to synthetic leather and relates to the technical field of synthetic leather functional auxiliaries. The waterborne anti-sticking agent is prepared by, by weight, 15-20 parts of oxidized polyethylene wax-hydrolytic polymaleic anhydride grafted copolymer, 5-10 parts of water-soluble modified crospovidone, 3-5 parts of volcanic ash, 3-5 parts of croscarmellose, 2-3 parts of ultrafine ceramic powder, 2-3 parts of carnauba wax, 1-2 parts of asbestos powder, 0.5-1 part of polyaluminum chloride, 0.5-1 part of nano titanium dioxide, 0.2-0.3 part of molecular sieve raw powder, 0.05-0.1 part of yttrium oxide and 150-200 parts of water. The waterborne anti-sticking agent has the advantages that the waterborne anti-sticking agent is added into a soaking box for post-processing the synthetic leather, sticking of the synthetic leather during rolling drying and subsequent grain kneading after soaking is prevented, the surface quality of the synthetic leather after the grain kneading is increased, and surface damage of the synthetic leather is avoided.

A rebeprazole sodium enteric-coated tablet comprises, by weight, 65-125 parts of tablet core, 10-40 parts of isolation layer and 80-170 parts of enteric-coated layer, wherein filler is one or more of microcrystalline cellulose, lactose and mannitol, stabilizer is one or more of magnesium oxide and anhydrous sodium carbonate, disintegrating agent is one or more of polyvinyl pyrrolidone, cross-linking sodium carboxymethyl cellulose and lauryl sodium sulfate, lubricating agent is one or two of talcum powder and magnesium stearate, binder is the anhydrous ethanol solution of crospovidone or the aqueous solution of hydroxypropyl methylcellulose, the isolation layer is one or two of magnesium oxide and ethyl cellulose, and the enteric-coated layer is one or more of hydroxypropyl methylcellulose phthalic acid ester, enteric-coated acrylic resin, cellulose acetate phthalic ester, talcum powder and 93F19255 type coating agent. A preparation process of the rebeprazole sodium enteric-coated tablet is simple, low in equipment requirement, high in yield, and controllable in product quality. The dissolution rate of the rebeprazole sodium enteric-coated tablet is highly consistent with the release behavior of originally-developed drugs, and the rebeprazole sodium enteric-coated tablet is good in stability.

The invention provides a prucalopride succinate tablet composition and a preparation method thereof. The prucalopride succinate tablet contains prucalopride succinate, mannitol, crospovidone and the like. The prucalopride succinate tablet has the advantages that a Maillard reaction is not generated; the tablet can be prepared via a wet granulation method; the tablet is high in stability and the like.

The invention belongs to the field of pharmaceutical preparations, and relates to ramelteon sublingual tablets and a preparation method thereof. The sublingual tablet contains effective amounts of ramelteon, a filler, a disintegrant, a lubricant, and a flavoring agent, and the proportion of a main drug is 0.1 to 0.5%; the filler is selected from one or a combination of mannitol, lactose, sucrose and xylitol; the disintegrant is selected from one or the combination of crospovidone, cross linked sodium carboxymethyl cellulose, and low-substituted hydroxypropyl cellulose; and the lubricant is selected from one or a combination of magnesium stearate, aerosil, and sodium stearyl fumarate; and the flavoring agent is mint flavor. The invention also provides the preparation method of the ramelteonsublingual tablets, that is, ramelteon and the filler are ground and mixed by a ball mill, and mixed with the disintegrating agent, the lubricant, and the flavoring agent, and the materials are pressed to prepare tablets. The ramelteon sublingual tablet of the invention can avoid the first pass effect of the liver and improve the bioavailability.

The invention relates to olanzapine orally disintegrating tablets and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The novel pharmaceutical composition is prepared from olanzapine granules and an additive, wherein the olanzapine granules are prepared from olanzapine, mannitol, crospovidone and a water disperse system of polyvinyl acetate through granulation. The invention further relates to the olanzapine granules and the preparation method of the olanzapine orally disintegrating tablets.

The invention discloses paracetanol DC90 fine particles and a preparation method thereof. The paracetanol DC90 comprises following materials by weight ratio: 90 percent of paracetanol, 3.50 percent of cornstarch, 3.50 percent of pre gelatinized starch, 2.00 percent of povidone, 0.5 percent of crospovidone and 0.5 percent of stearic acid. Firstly, the paracetanol and the cornstarch are mixed evenly, then the pre gelatinized starch and the povidone are made into starch slurry to be used as bond which is evenly sprayed on the mixture of the fluidied paracetanol and cornstarch, fluidized bed granulation is carried out in the inlet air temperature, the wet particles are dried under the temperature of 80 DEG C and then are cooled at the temperature of 50 DEG C till water conforms to the requirement, the sizes of the particles are adjusted, the stearic acid and the crospovidone are added after the particle sizes are adjusted to be mixed evenly to obtain the paracetanol DC90 fine particles. The invention adopts the above technical proposal to inspect the product, and the particles are fine and uniform and have favorable fluidity, thereby being well and evenly mixed with other small quantities of active components powder.

The invention discloses an infantile domperidone orally disintegrating tablet and a preparation method thereof. The orally disintegrating tablet is prepared from the following raw materials in parts by mass: 10 to 30 parts of domperidone, 10 to 30 parts of fatty glyceride, 5 to 10 parts of tween 80, 900 to 2700 parts of white sugar, 2 to 5 parts of crospovidone, 10 to 30 parts of mannitol, 0.01 to 0.05 part of essence, 0.2 to 0.5 part of magnesium stearate and 0.2 to 0.5 part of aerosil. According to the infantile domperidone orally disintegrating tablet and the preparation method thereof, an orally disintegrating tablet medicament is prepared by using the domperidone as an effective component of the medicament and through an innovative process. By using the domperidone orally disintegrating tablet prepared by the invention, the problems that the dissolution rate of the medicament is low, the medicament has a bitter taste, and the like, are solved successfully; the infantile domperidone orally disintegrating tablet has a favorable effect on infantile functional dyspepsia.

The invention relates to a synthesis method and especially relates to a synthesis method of crospovidone and belongs to the field of medicinal auxiliary materials. The synthesis method includes the steps of: dissolving anhydrous sodium sulfate, anhydrous disodium hydrogen phosphate and polyvinylpyrrolidone K30 in purified water in a water-bath heating manner; adding N-vinyl pyrrolidone and filling the reaction system with nitrogen gas; and when the temperature of the solution is increased to 50-80 DEG C, adding a hydrogen peroxide solution and divinylbenzene to perform a polymerization reaction for 3-9.5 h. The synthesis method employs safe and cheap hydrogen peroxide as a catalyst, wherein the polymerization is initiated by means of free radicals generated during a redox reduction of the hydrogen peroxide which is then decomposed into water and oxygen, so that the method is safe and toxic-free.

The invention discloses a high-strength composite packaging material and a preparation method thereof. The high-strength composite packaging material comprises the following raw materials in parts by weight: 20 to 45 parts of chlorinated butyl rubber, 15 to 30 parts of polybutadiene, 10 to 20 parts of poly(butylene succinate), 3 to 7 parts of polycaprolactone, 14 to 20 parts of nano-carbon fibres, 3 to 6 parts of trimethylolpropane, 1 to 3 parts of silicone oil, 5 to 8 parts of nano-graphite powder, 2 to 8 parts of zinc oxide, 12 to 20 parts of polyvinyl alcohol, 7 to 15 parts of polyvinylidene chloride, 3 to 12 parts of acrylic acid, 3 to 6 parts of magnesium hydrate, 4 to 12 parts of succinimide, 3 to 8 parts of propylene glycol monomethyl ether, 3 to 7 parts of sodium melamine phosphate, 3 to 6 parts of a wear-resistant agent, 1 to 5 parts of crospovidone and 3 to 8 parts of tetramethoxysilane. Compared with the prior art, the packaging material disclosed by the invention has the advantages of high strength, long service life, simple preparation method and the like, so that requirements on industrial production can be met better.