A puncture instrument set is constituted by a puncture instrument which includes a cylindrical body, plural puncture needles to be held in a state where the puncture needles are connected in series in an axis direction, a puncture needle
cartridge for linearly arranging the plural puncture needles in the body, a stopping member for stopping the puncture needle
cartridge at a predetermined position in its axis direction, and an elastic biasing member for biasing the puncture needle
cartridge in one direction; and a puncture needle replacement jig that enables, after
puncturing by the puncture needle, setting of the puncture needle cartridge at the puncture position as well as disposal of the used puncture needle, for a subsequent puncture operation. Thereby, it is an object to provide a high-security puncture instrument set for
puncturing the surface of a biologic body, which is provided with plural puncture needles, and is able to perform
puncturing continuously by a simple operation.