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Amoxicillin capsule and production method thereof

A technology of amoxicillin and capsules, which is applied in the field of medicine, can solve problems such as the application of micronization technology, achieve the effects of reducing the amount of excipients, simplifying the preparation process, and reducing toxic and side effects

Inactive Publication Date: 2009-03-25
HAINAN MEIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Airflow ultrafine pulverization technology is a kind of ultrafine pulverization technology. It uses the material to obtain huge energy under the action of high-speed airflow, causing high-speed collision and severe friction between material particles in the pulverization chamber. Shearing effect, so as to achieve the purpose of crushing materials, it can process raw materials into very fine powder, at present, this technology is mainly used in traditional Chinese medicine, almost no micronization technology is applied to chemical drugs or western medicine, used to improve medicine Application of formulation defects

Method used

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  • Amoxicillin capsule and production method thereof
  • Amoxicillin capsule and production method thereof
  • Amoxicillin capsule and production method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Embodiment 1 Preparation of Amoxicillin Capsules

[0026] Weigh 1250g of amoxicillin and 300g of lactose and mix evenly, inject the mixture and dry nitrogen into the ultrafine pulverizer, use high-speed airflow to pulverize, the working pressure is 1.2MP, the internal working temperature is 50°C, the pulverization time is 40min, and then take out Fine powder, passed through a 500-mesh sieve, all passed through, mixed the fine powder and 100g sodium starch glycolate evenly, added 5% povidone K30 ethanol solution and mixed to prepare a soft material, passed through a 20-mesh sieve to make wet granules, dried at 50°C, 20 Mesh sieve for granulation, add 13.46g of magnesium stearate, mix well, and fill capsules.

Embodiment 2

[0027] The preparation of embodiment 2 amoxicillin capsules

[0028] Weigh 1000g of amoxicillin and 240g of mannitol and mix evenly, inject the mixture and dry air into the ultrafine pulverizer, use high-speed airflow to pulverize, the working pressure is 1.0MP, the internal working temperature is 45°C, and the pulverization time is 30min, then Take out the fine powder, pass through a 1000-mesh sieve, and pass it all, mix the fine powder and 80g of low-substituted hydroxypropyl cellulose evenly, add 5% povidone K30 ethanol solution and mix to prepare a soft material, pass through a 20-mesh sieve to make wet granules, and heat at 50°C Dried, granulated with a 20-mesh sieve, added with 10.57g of magnesium stearate and 12.33g of talcum powder, mixed evenly, and filled into capsules.

Embodiment 3

[0029] Example 3 Preparation of Amoxicillin Capsules

[0030] Weigh 500g of amoxicillin and 100g of starch and mix evenly, inject the mixture and dry nitrogen into the ultrafine pulverizer, use high-speed airflow to pulverize, the working pressure is 1.1MP, the internal working temperature is 40°C, the pulverization time is 40min, and then take out Fine powder, pass through 800 mesh sieve, all pass through, mix fine powder with 80g microcrystalline cellulose, 20g crospovidone evenly, add 2% hypromellose 70% ethanol solution and mix to prepare soft material, pass through 20 mesh Sieve wet granules, dry at 50°C, sieve with a 20-mesh sieve, add 5.014g of magnesium stearate, mix well, and fill capsules.

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Abstract

The invention relates to an amoxicillin capsule and the preparation method thereof, in particular to a method of adopting the micropowder technology to prepare amoxicillin capsules. The method utilizes the micropowder technology to overcome the bad dissolution of the amoxicillin capsule in the prior art; meanwhile, the amoxicillin capsule prepared by the method has the advantages of improving the preparation stability, simplifying the preparation process, reducing the toxic and side effects.

Description

technical field [0001] The invention relates to a method for preparing amoxicillin capsules, in particular to a method for preparing amoxicillin capsules by adopting micronization technology. The method overcomes the problem of poor dissolution rate of amoxicillin capsules in the prior art by utilizing the micronization technology, improves the stability of the preparation, simplifies the preparation process, and reduces toxic and side effects. The invention belongs to the technical field of medicine. Background technique [0002] Amoxicillin is a semi-synthetic broad-spectrum penicillin drug, which is characterized by broad antibacterial spectrum and strong bactericidal effect. It also promotes wound healing. [0003] Amoxicillin is slightly soluble in water and almost insoluble in ethanol. The poor solubility determines the poor dissolution rate of its capsule preparations. Solving the dissolution problem has become a difficult problem for amoxicillin capsules. It is re...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/43A61P31/04
Inventor 邱民
Owner HAINAN MEIDA PHARMA
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