62 results about "Toltrazuril" patented technology

The invention relates to a preparation method of a toltrazuril-cyclodextrin inclusion compound. The method comprises the following steps: the toltrazuril is dissolved in the dilute alkaline solution and performs inclusion with cyclodextrin or the derivative thereof at the temperature of 20 to 80 DEG C, the entire system is neutralized with acid, the resultant is dried and crushed and then the toltrazuril-cyclodextrin inclusion compound is obtained. The invention does not utilize the organic solvent for dissolving and has the advantages of simple process, easy control, low cost and mass production; and the prepared inclusion compound has high security, good stability and good dissolvability and is convenient to use.

The present invention belongs to the field of veterinary medicine preparations, and particularly relates to a toltrazuril nano-suspension and a preparation method thereof. The nano-suspension is prepared by micronizing the main drug toltrazuril and accessories. The massic volume percentage content of toltrazuril in the nano-suspension is 0.01-5.00%. The accessories include by volume: 10-70% of an organic solvent, 0.01-20.0% of a surfactant, 0.1-5.0% of a suspending agent, 0.1-2.5% of an antioxidant, and the balance being water. The toltrazuril nano-suspension of the present invention is convenient for administration, high in medicine utilization, and accurate in dosage of administration, helps to improve the bioavailability of the medicine, and is simple in production process and suitable for industrial production.

The invention relates to a preparation method of a toltrazuril molecular imprinting electrochemical sensor. The preparation method comprises the following steps: taking toltrazuril as the template molecule, carboxylated beta-cyclodextrin as the functional monomer, and tetraethyl ortho-silicate as the crosslinking agent, carrying out reactions under an acidic condition to obtain a toltrazuril sol imprinted polymer; dropwise painting a reduced graphene dispersion liquid on a platinum electrode (phi 2mm), drying the platinum electrode under an infrared lamp; then dropwise painting an aminated titanium dioxide dispersion liquid on the platinum electrode, drying the platinum electrode under an infrared lamp; then dropwise painting the toltrazuril sol imprinted polymer on the platinum electrode, drying the platinum electrode at a room temperature; placing the platinum electrode in a HCl solution, and washing off the template molecules in a thermostatic water bath to obtain a toltrazuril molecular imprinting electrochemical sensor. The operation is simple, the coating is firm, the template molecules can be easily washed out, and the prepared molecular printing electrochemical sensor has the advantages of stability, good repeatability, high sensitivity, and good selectivity, and can be used to detect toltrazuril in food and feed.

The invention discloses a specific medicine used for treating coccidiosis and a preparation method of the specific medicine. The specific medicine is mainly prepared from diclazuril, decoquinate and toltrazuril. Every 100 ml of the medicament comprises, by weight, 0.45-0.55 g of diclazuril, 3.6-4.4 g of decoquinate and 1.8-2.2 g of toltrazuril. The preparation method comprises the fours steps of aqueous preparation, oil phase preparation, emulsion and dissolution promotion. The pecific medicine is mainly prepared from diclazuril, decoquinate and toltrazuril. The effect of treating the coccidiosis is improved through the synergistic effect of diclazuril, decoquinate and toltrazuril, and the drug resistance is lowered. Formed double solvents can effectively improve the solubility of the main medicine components in water, and main medicine can be stable in the preparation and is easily dissolved in water. Meanwhile, the special medicine has the advantages of being capable of taking effects fast, short in drug withdrawal period, high in death rate control and reduction, high in drug bioavailability and the like.

The invention discloses a separation pipe for preparing a sample for detecting the content of toltrazuril in blood. The separation pipe is composed of an inner cylinder and an outer cylinder, whereinan upper portion and a lower portion of the inner cylinder are open, the inner cylinder extends into the outer cylinder from a pipe opening of the outer cylinder, an annular cavity formed between theinner cylinder and the outer cylinder is a separation cavity, a filtering filler layer is arranged at the bottom of the separation cavity, a liquid extraction pipe is arranged in the inner cylinder body and extends into the outer cylinder body from a pipe opening of the inner cylinder, a sealing gasket is arranged between the opening of the liquid extraction pipe and the opening of the inner cylinder, the liquid extraction pipe is also provided with an air guide pipe, the bottom of the air guide pipe is connected with an air guide port which is 10-20mm away from a bottom wall, the top of the gas guide pipe is communicated with an air cavity at an upper part of the inner cylinder, and a filter film is arranged on the bottom wall of the liquid extraction pipe. The invention also discloses amethod for detecting the content of toltrazuril in the blood by using high performance liquid chromatography after the blood is treated into a sample to be analyzed by using the separation pipe, and the method for detecting the content of toltrazuril in blood has advantages of simple operation, few steps and high experiment efficiency.

The invention discloses a compound solution of toltrazuril and diclazuril and a preparation method and application thereof, belonging to the field of livestock / poultry coccidiosis prevention. The compound solution of toltrazuril and diclazuril, disclosed by the invention, consists of main medicines and an accessory, wherein the main medicines include toltrazuril and diclazuril; preferably the mass ratio of the diclazuril to the toltrazuril is 1:(3-5), and the content of toltrazuril accounts for 2-10% of the solution by mass; the accessory is a compound solvent consisting of ethanol, diethanol amine and propylene glycol; the diethanol amine is a pH regulator which regulates the pH value of the compound solution to 8-10; and the propylene glycol is a diluting solvent. According to the prepared compound solution, the actual use concentration of toltrazuril is greatly reduced, and the cost is lowered; and the detection result also shows that the prepared compound solution is an efficient anticoccidial drug and has good stability.

The invention relates to improved methods for protecting non-human animals with triazine compounds by intramuscular or subcutaneous injection(s). The invention can be used with various triazines, such as toltrazuril, in different non-human animals, such as a porcine, an ovine, a bovine, a canine, a feline, or an avian, for protecting them against infectious diseases, such as protozoan disorders.