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Compound anti-parasitic preparation and preparation method thereof

An anti-parasitic and preparation technology, which is applied in pill delivery, anti-infective drugs, pharmaceutical formulations, etc., can solve the problems of poor treatment effect, difficulty in effectively and comprehensively treating nematode parasitic diseases, narrow anti-insect spectrum, etc., and achieves good uniformity , improve the use effect and safety performance, and promote the effect of dissolution

Inactive Publication Date: 2018-02-16
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional ivermectin tablet is a single preparation with a narrow anti-insect spectrum, and it is difficult to effectively and comprehensively treat parasitic diseases such as nematodes, tapeworms, and coccidia, especially for the treatment of diseases caused by mutual infection between different parasites poor

Method used

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  • Compound anti-parasitic preparation and preparation method thereof
  • Compound anti-parasitic preparation and preparation method thereof
  • Compound anti-parasitic preparation and preparation method thereof

Examples

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preparation example Construction

[0053] A preparation method of a compound antiparasitic preparation, comprising the following steps:

[0054] 1) Weighing and sieving: Weigh ivermectin, mebendazole, toltrazuril, disintegrants, fillers, lubricants, adhesives and other auxiliary materials according to the above parts by weight, and the weighed ivermectin Vermectin, mebendazole, toltrazuril and auxiliary materials are respectively pulverized and sieved through a 60-120 mesh sieve. Optionally, the adjuvant also includes a flavoring agent and a preservative, and the flavoring agent and the preservative are respectively weighed by the above parts by weight.

[0055] 2) Preparation of ivermectin solid dispersion: Add the sieved ivermectin to absolute ethanol to dissolve completely, then add part of the sieved filler and mix evenly, and then dry, pulverize and sieve , to prepare the ivermectin solid dispersion, wherein the content of the ivermectin in the ivermectin solid dispersion is 1%-5%.

[0056] In one embodi...

Embodiment 1～13

[0077] The composition of the compound antiparasitic preparations in Examples 1-13 is shown in Table 1. The corresponding numerical value of various raw materials in table 1 is the parts by weight of this raw material.

[0078] The composition of table 1 compound antiparasitic preparation

[0079]

[0080]

[0081] 1. the preparation method of embodiment 1-7 is as follows:

[0082] 1) Weigh respectively ivermectin, mebendazole, toltrazuril, crospovidone, lactose, microcrystalline cellulose, maltodextrin, beef essence, magnesium stearate, polydextrin according to the above-mentioned parts by weight. Vitone and ethyl paraben. The weighed raw materials were respectively pulverized and sieved through a 100-mesh sieve.

[0083] 2) Add the ivermectin and ethyl p-hydroxybenzoate into absolute ethanol to dissolve completely, then add part of lactose and mix evenly, dry in an oven at a temperature of 55°C-60°C for 4-5 hours, pulverized, and sieved through a 100-mesh sieve to ...

Embodiment 8-10

[0088] 2. The preparation method of embodiment 8-10 is as follows:

[0089] 1) Take respectively ivermectin, mebendazole, toltrazuril, cross-linked povidone, lactose, magnesium stearate and povidone by the above-mentioned parts by weight. The raw materials weighed were pulverized respectively and sieved through a 100 mesh sieve.

[0090] 2) Add the ivermectin to absolute ethanol to dissolve completely, then add some lactose and mix evenly, dry it in an oven at 55°C-60°C for 4-5 hours, crush it, and pass through a 100-mesh sieve After sieving, an ivermectin solid dispersion containing 1% ivermectin was prepared.

[0091] 3) Add the povidone sieved in step 1) into purified water to prepare an aqueous solution of povidone with a concentration of 3% (w / v).

[0092] 4) Mix the sieved mebendazole, toltrazuril, crospovidone, remaining lactose, and step 2) the ivermectin solid dispersion prepared in step 1) according to an equal incremental method, and add Step 3) The prepared aque...

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Abstract

The invention relates to a compound anti-parasitic preparation, and a preparation method and application thereof. The compound anti-parasitic preparation is mainly prepared from the following raw materials in parts by weight: 0.04 to 0.1 part of ivermectin, 5 to 10 parts of mebendazole, 5 to 15 parts of toltrazuril, 3 to 10 parts of a disintegrating agent, 61 to 91 parts of a filling agent, 1 to 3parts of a lubricating agent and 0.3 to 1 part of an adhesive. The compound anti-parasitic preparation has high uniformity and has a good anti-parasitic effect.

Description

technical field [0001] The invention relates to the technical field of antiparasitic drugs, in particular to a compound antiparasitic preparation and a preparation method thereof. Background technique [0002] Along with the raising of economic capacity, more and more people keep dogs, cats etc. as pets. For example, dogs can not only add fun to people's ordinary life, but also relieve people's inner loneliness and pressure. However, dogs are mammals and are susceptible to parasitic diseases such as nematodes, tapeworms, and coccidiosis. If they cannot be treated in time, they will not only affect the health of dogs, but also increase the risk of human beings infected with parasitic diseases. In addition, since dogs and other mammals are also prone to cross-infection with bacterial parasites in daily life, and different bacterial parasites can infect each other, they will suffer from diseases of various etiologies. [0003] Ivermectin is a new type of low-toxic antibiotic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/20A61K47/36A61K47/38A61K47/26A61P33/02A61P33/10A61P33/14A61K31/4184A61K31/53
CPCA61K31/7048A61K9/2018A61K9/2054A61K9/2059A61K31/4184A61K31/53A61K2300/00
Inventor 陶映娴周淑贞马静蓉林孝崇黄海青
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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