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Preparation method of toltrazuril solid dispersion

A technology of solid dispersion and toltrazuril, which is applied in non-active ingredients medical preparations, pharmaceutical formulations, active ingredients of heterocyclic compounds, etc. and other problems, to achieve the effect of improving solubility and simple preparation process

Inactive Publication Date: 2012-10-31
QINGDAO LVMAN BIOLOGICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the poor water solubility of Toltrazuril, it has brought great trouble to clinical application and affected its popularization and use.

Method used

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  • Preparation method of toltrazuril solid dispersion
  • Preparation method of toltrazuril solid dispersion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0018] A kind of preparation method of Toltrazuril solid dispersion, carry out as follows: (every part is calculated by 10g)

[0019] (1) Take by weight 100 parts of Toltrazuril (over 80 mesh sieves), 200 parts of polyvinylpyrrolidone, and 600 parts of ethanol;

[0020] (2) The toltrazuril and polyvinylpyrrolidone are mixed and stirred until uniform;

[0021] (3) The mixture obtained in (2) is quickly added to ethanol, stirred evenly, heated to evaporate the ethanol to obtain a precipitate, dried and pulverized to obtain Toltrazuril solid dispersion.

[0022] Example:

[0023] A kind of preparation method of Toltrazuril solid dispersion, carry out as follows: (every part is calculated by 10g)

[0024] (1) Take by weight 120 parts of Toltrazuril (over 80 mesh sieves), 250 parts of polyvinylpyrrolidone, and 800 parts of ethanol;

[0025] (2) The toltrazuril and polyvinylpyrrolidone are mixed and stirred until uniform;

[0026] (3) The mixture obtained in (2) is quickly added...

Embodiment 3

[0028] A kind of preparation method of Toltrazuril solid dispersion, carry out as follows: (every part is calculated by 10g)

[0029] (1) Take by weight 150 parts of Toltrazuril (over 80 mesh sieves), 300 parts of polyvinylpyrrolidone, and 1000 parts of ethanol;

[0030] (2) The toltrazuril and polyvinylpyrrolidone are mixed and stirred until uniform;

[0031] (3) The mixture obtained in (2) is quickly added to ethanol, stirred evenly, heated to evaporate the ethanol to obtain a precipitate, dried and pulverized to obtain Toltrazuril solid dispersion.

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Abstract

A preparation method of a toltrazuril solid dispersion relates to the field of animal medicines. The toltrazuril solid dispersion is prepared by uniformly and sequentially mixing the following components in part by weight: 10-15 parts of toltrazuril (passing through an 80-mesh sieve), 20-30 parts of polyvinyl pyrrolidone and 60-100 parts of ethanol. The preparation method comprises the following steps: (1), weighing 10-15 parts of toltrazuril (passing through the 80-mesh sieve), 20-30 parts of polyvinyl pyrrolidone and 60-100 parts of ethanol in part by weight; (2), mixing the toltrazuril and the polyvinyl pyrrolidone, and stirring uniformly; and (3), quickly adding a mixture obtained in the step (2) into the ethanol, stirring uniformly, heating to evaporate the ethanol and obtain the precipitate, drying, and pulverizing to obtain the toltrazuril solid dispersion. The preparation method is simple in process; the solubility of the toltrazuril is significantly improved; and the dissolution of the toltrazuril is about 2 times that of an ordinary toltrazuril preparation (soluble powder or oral liquid).

Description

technical field [0001] The invention relates to the field of animal medicine, in particular to a preparation method of Toltrazuril solid dispersion. Background technique [0002] Toltrazuril is a white or off-white crystalline powder. It is a new type, high-efficiency, and low-toxicity anticoccidiostat, and is widely used in the prevention and treatment of chicken coccidiosis. [0003] Due to the poor water solubility of Toltrazuril, it has brought great troubles to clinical application and affected its popularization and use. Therefore developing a new technology to overcome the above-mentioned shortcoming of toltrazuril is one of the new issues to be solved urgently by scientific research technicians in this field. Contents of the invention [0004] The purpose of the present invention is to overcome above-mentioned disadvantages, and provide a kind of preparation method of Toltrazuril solid dispersion with simple process, stable quality and good water solubility. [0...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/53A61K47/32A61P33/02
Inventor 周庆福刘文利
Owner QINGDAO LVMAN BIOLOGICAL ENG
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