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Preparation method of toltrazuril soluble powder

A toltrazuril and soluble technology, applied in the field of preparation of toltrazuril soluble powder, can solve the problems of seldom application, late start of domestic veterinary drug preparations, etc., and achieves simple and easy method, excellent economic and social benefits, Rapid dissolving effect

Inactive Publication Date: 2010-07-14
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented process involves mixing two different chemicals together called tizasolidinium salt and lysine hydrochloride into small particles which help break down them easily when mixed properly. These tiny particles form an insoluble solution containing these compounds. By adding this substance to the original composition, there will become more solvable over time. Compared to other methods like suspending agents, they provide better results due to their ability to release active ingredient slowly while still being able to maintain its effectiveness during storage and handling.

Problems solved by technology

The technical problem addressed in this patented text relates to finding ways to make stable liquid compositions containing tertrazone that have improved efficacy when administered orally due to reduced side effects compared with current methods such as injection into animals' veins.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Stir 60 g of polyethylene glycol 4000 at 80° C. until it completely melts to obtain a transparent liquid, then add 9 g of toltrazuril into the liquid polyethylene glycol 4000 and stir until the toltrazuril is uniformly dispersed. Then add 31g of L-arginine to the above mixture and stir evenly, then quickly cool down the mixture to 0°C to solidify, dry the cured product at room temperature and crush it through a 40-mesh sieve, generally 40-60 mesh The sieve is acceptable, and the soluble powder of Toltrazuril can be obtained.

[0016] Use comparative method to study the solubilization effect of this process on toltrazuril in water, the specific method is: take 0.3g of toltrazuril soluble powder prepared in this example, add it to 100ml water at 25°C and stir for 10min, then let it stand for 30min Observed, it was found that the soluble powder of Toltrazuril was completely dissolved in water without insoluble matter. It can be calculated that the solubility of pure toltr...

Embodiment 2

[0018] Stir 60 g of polyethylene glycol 6000 at 80° C. until it completely melts to obtain a transparent liquid, then add 10 g of toltrazuril into the liquid polyethylene glycol 6000 and stir until the toltrazuril is uniformly dispersed. Then add 30g of L-arginine to the above mixture and stir evenly, then quickly cool down the mixture to 0°C to solidify, dry the solidified product at room temperature and crush it through a 40-mesh sieve to obtain Toltrazuril Soluble powder.

[0019] Using the same method as in Example 1 to study the solubilization effect of this process on toltrazuril in water, it is calculated that the solubility of pure toltrazuril in water has reached at least 300mg / L, which is at least 750 times that reported in the literature.

Embodiment 3

[0021] Stir 65g of polyethylene glycol 6000 at 100°C until it completely melts to obtain a transparent liquid, then add 11g of toltrazuril into the liquid polyethylene glycol 6000 and stir until the toltrazuril is evenly dispersed. Then add 24g of L-arginine to the above mixture and stir evenly, then quickly cool the mixture to -5°C to solidify, dry the solidified product at room temperature, crush it, and pass it through a 40-mesh sieve to obtain Toqu Julius Soluble Powder.

[0022] Using the same method as in Example 1 to study the solubilization effect of this process on toltrazuril in water, it is calculated that the solubility of pure toltrazuril in water has reached at least 330 mg / L, which is at least 825 times that reported in the literature.

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Abstract

The invention discloses a preparation method of toltrazuril soluble powder, which adopts toltrazuri as main drug and polyethyleneglycol and L-arginine as auxiliary materials, and comprises the following steps according to a given dosage proportion: polyethyleneglycol is molten, toltrazuri is dissolved in the polyethyleneglycol, then the L-arginine is added to be uniformly mixed, the mixture is cooled down to be solidified and to be dried, smashed and sieved at the room temperature so as to obtain the toltrazuri soluble powder; and the polyethyleneglycol is polyethyleneglycol 4000, polyethyleneglycol 6000, polyethyleneglycol 8000 or polyethyleneglycol 10000. The preparation method is simple and easy, and can remarkably improve the solubility of the toltrazuril in the water. The prepared soluble powder has good stability, is convenient for animals to use, has low residue, and has excellent economic benefit and social benefit.

Description

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Claims

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Application Information

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Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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