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Toltrazuril nano-suspension and preparation method thereof

A nano-suspension and toltrazuril technology, which is applied in the direction of emulsion delivery, drug combination, anti-infective drugs, etc., can solve the inconvenient way of mixing materials, inaccurate dosage, difficult feed mixing, etc. problem, to achieve the effect of improving bioavailability, solving the inconvenience of administration, and stabilizing the suspension system

Inactive Publication Date: 2013-03-20
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because toltrazuril is insoluble in water, if it is administered as a premixed agent, due to the particularity of chicken feeding habits, the method of administering the mixture is not only inconvenient, but also difficult to mix with the feed, resulting in drug administration. The dosage is inaccurate, and there are shortcomings such as serious drug waste, which limit its application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The prescription of Toltrazuril Nanosuspension:

[0025] components content Toltrazuril 5.0% (W / V) Polysorbate 80 1.0% (V / V) polyethylene glycol 400 0.5% (V / V) Sodium carboxymethyl cellulose 0.5% (W / V) Anhydrous sodium sulfite 0.1% (W / V) purified water 30.0% (W / V) N,N-Dimethylformamide Add to 100.0%

[0026] The preparation method of Toltrazuril nano-suspension is as follows:

[0027] (1) Dissolve anhydrous sodium sulfite in a small amount of purified water first, stir and dissolve to obtain solution A;

[0028] (2) Take an appropriate amount of N,N-dimethylformamide, add Toltrazuril and stir to fully dissolve it to obtain solution B;

[0029] (3) Take an appropriate amount of purified water, add sodium carboxymethylcellulose, heat to dissolve, and let cool to obtain solution C;

[0030] (4) Slowly add polysorbate 80 and polyethylene glycol 400 to liquid B and mix evenly, add N,N-dimethylformamide in an a...

Embodiment 2

[0035] The prescription of Toltrazuril Nanosuspension:

[0036] components content Toltrazuril 2.5% (W / V) Sodium dodecyl sulfonate 1.5% (V / V) Sodium carboxymethyl cellulose 0.5% (W / V) Anhydrous sodium bisulfite 0.1% (W / V) purified water 30.0% (V / V) Dimethyl sulfoxide 50.0% (V / V) ethanol Add to 100.0%

[0037] The preparation method of Toltrazuril nano-suspension is as follows:

[0038] (1) First dissolve anhydrous sodium bisulfite in a small amount of purified water, stir and dissolve to obtain solution A.

[0039] (2) Take an appropriate amount of dimethyl sulfoxide, add Toltrazuril and stir to dissolve it fully, and obtain solution B;

[0040] (3) Take an appropriate amount of purified water, add sodium carboxymethylcellulose, heat to dissolve, and let cool to obtain solution C;

[0041] (4) Slowly add sodium dodecyl sulfonate into liquid B and mix evenly, add an appropriate amount of dimethyl sulfoxide and mi...

Embodiment 3

[0046] The prescription of Toltrazuril Nanosuspension:

[0047] components content Toltrazuril 5.0% (W / V) Sodium dodecyl sulfonate 5.0% (V / V) Sodium carboxymethyl cellulose 5.0% (W / V) Anhydrous sodium bisulfite 2.5% (W / V) ethanol Add to 100.0% Dimethyl sulfoxide 50.0% (V / V) purified water 22.5 (V / V)

[0048] The preparation method of Toltrazuril nano-suspension is as follows:

[0049] (1) First dissolve anhydrous sodium bisulfite in a small amount of purified water, stir and dissolve to obtain solution A.

[0050] (2) Take an appropriate amount of dimethyl sulfoxide, add Toltrazuril and stir to dissolve it fully, and obtain solution B;

[0051] (3) Take an appropriate amount of purified water, add sodium carboxymethylcellulose, heat to dissolve, and let cool to obtain solution C;

[0052] (4) Slowly add sodium dodecyl sulfonate into liquid B and mix evenly, add an appropriate amount of dimethyl sulfoxide and mix...

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Abstract

The present invention belongs to the field of veterinary medicine preparations, and particularly relates to a toltrazuril nano-suspension and a preparation method thereof. The nano-suspension is prepared by micronizing the main drug toltrazuril and accessories. The massic volume percentage content of toltrazuril in the nano-suspension is 0.01-5.00%. The accessories include by volume: 10-70% of an organic solvent, 0.01-20.0% of a surfactant, 0.1-5.0% of a suspending agent, 0.1-2.5% of an antioxidant, and the balance being water. The toltrazuril nano-suspension of the present invention is convenient for administration, high in medicine utilization, and accurate in dosage of administration, helps to improve the bioavailability of the medicine, and is simple in production process and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a Toltrazuril nano-suspension and a preparation method thereof. Background technique [0002] Chicken coccidiosis is a chicken parasitic disease caused by Eimeria coccidiosis. Most of them break out in young animals, and the mortality rate is as high as 30%. It is currently the most harmful parasitic disease to the chicken industry. There is no cross-immunity between the various species of Eimeria, and it is easy to break out coccidiosis caused by different species. The modern large-scale and closed breeding mode makes it difficult to control the disease, and the effect of conventional drug prevention, disinfection and vaccine prevention is very weak. Toltrazuril (English name Toltrazuril), also known as 100 ball clear, toltrazine, methyl triazone or toltrazuril, etc., is a triazinone anticoccidial anticoccidial developed by Bayer in the 1980s. drug. Toltrazuril has...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/53A61P33/02
Inventor 李玮君李坤鹏
Owner HENAN SOAR VETERINARY PHARMA
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