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Novel compound anti-coccidiosis medicament and preparation method thereof

An anti-coccidial and compound technology, applied in the direction of anti-infective drugs, drug combinations, active ingredients of heterocyclic compounds, etc., can solve the problems of low bioavailability, difficult to absorb, difficult to dissolve in water, etc. Medicinal properties, the effect of reducing dosage

Inactive Publication Date: 2011-01-05
山东步步赢生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, decoquinate and toltrazuril are not easily soluble in water, difficult to absorb, have low bioavailability, and are prone to drug resistance

Method used

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  • Novel compound anti-coccidiosis medicament and preparation method thereof
  • Novel compound anti-coccidiosis medicament and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0018] A new type of compound anticoccidial drug, made of the following components by weight: 2.2 grams of decoquinate, 23 grams of polyethylene glycol 6000, 1.8 grams of toltrazuril, 30 grams of cyclodextrin, 8 grams of sodium carbonate, Water glucose 35 grams.

Embodiment 2

[0020] This novel compound anticoccidial drug is made of the following components by weight: 1.5 grams of decoquinate, 15 grams of polyvinylpyrrolidone, 2.5 grams of toltrazuril, 30 grams of cyclodextrin, 20 grams of sodium carbonate, anhydrous Glucose 31 grams.

Embodiment 3

[0022] The preparation method of this novel compound anticoccidial drug adopts the following steps:

[0023] Mix 3 grams of decoquinate, 20 grams of polyethylene glycol 4000, and 10 grams of polyethylene glycol 6000, mix well, heat and melt at 110°C to a liquid state, then naturally cool to room temperature, and dry in vacuum at 35°C After 35 minutes, pulverize to 80 mesh, add 1.25 grams of Toltrazuril, 20 grams of cyclodextrin, 5 grams of sodium carbonate, and then add 40.75 grams of anhydrous glucose and stir evenly to obtain the novel compound anticoccidial drug of the present invention.

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Abstract

The invention discloses a medicament for treating coccidiosis, particularly a novel compound anti-coccidiosis medicament and a preparation method thereof. The novel compound anti-coccidiosis medicament is characterized by being prepared from the following components: decoquinate, toltrazuril, polymer carrier, solubilizing agent and anhydrous dextrose. Therefore, the medicament has the advantages that: the indissoluble decoquinate and toltrazuril are prepared into water-soluble substances by using solid dispersion technology and inclusion technology, and the decoquinate and toltrazuril are mixed to fulfill the aim of reducing dosage, improving curative effect and reducing drug resistance; moreover, the synergistic effect of the medicaments can be realized by combining the decoquinate and the toltrazuril, the killing effect is enhanced and the dosage of each medicament is reduced by half.

Description

(1) Technical field [0001] The invention relates to a medicine for treating coccidiosis, in particular to a novel compound anticoccidial medicine and a preparation method thereof. (2) Background technology [0002] Coccidiosis is a parasitic disease that damages the intestinal tract of poultry and is caused by various parasites of the genus Eimeria, including Eimeria acuminata, Eimeria brucei, Eimeria giganta Coccidia, Eimeria tenella, Eimeria venom, Eimeria metamorphosis, etc. These parasites reproduce in the intestinal epithelial cells, destroy the integrity of the intestinal mucosa, and reduce the digestion and absorption capacity of the intestinal tract. Coccidiosis is responsible for 6% to 10% of poultry mortality and leads to reduced poultry growth rate and feed conversion efficiency, resulting in global economic losses of billions of dollars per year. At present, the prevention and treatment of coccidiosis is mainly based on drugs, and the use of chemical drugs is st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/53A61K31/47A61P33/02
Inventor 张旭东李信安
Owner 山东步步赢生物科技有限公司
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