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Medicinal composition for treating or preventing obesity and metabolic syndromes

A metabolic syndrome and composition technology, applied in the field of medicine, to achieve the effects of stabilizing blood sugar concentration, reducing adverse reactions, and reducing the number of medications

Inactive Publication Date: 2013-01-16
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Based on the close relationship between obesity, diabetes and metabolic syndrome, and there is a certain risk in taking orlistat alone, the present invention provides a pharmaceutical composition of orlistat and acarbose for the treatment or prevention of obesity or metabolic syndrome

Method used

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  • Medicinal composition for treating or preventing obesity and metabolic syndromes
  • Medicinal composition for treating or preventing obesity and metabolic syndromes
  • Medicinal composition for treating or preventing obesity and metabolic syndromes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 compound tablet

[0020]

[0021] Preparation process: Weigh orlistat, acarbose, starch and microcrystalline cellulose in the prescribed amount and mix them evenly. In addition, add an appropriate amount of 15% starch slurry to the mixed powder, mix evenly, make soft materials, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 2

[0022] The preparation of embodiment 2 compound tablet

[0023]

[0024]

[0025] Preparation process: the preparation method is the same as in Example 1 except that the auxiliary materials are different.

Embodiment 3

[0027] a.

[0028]Preparation process: Orlistat is passed through a 100-mesh sieve, hydroxypropyl cellulose-4M and microcrystalline cellulose are passed through a 80-mesh sieve, and the prescribed amount of orlistat, hydroxypropyl cellulose-4M, and microcrystalline cellulose are weighed Mix the ingredients evenly, add an appropriate amount of 8% PVP absolute ethanol solution to granulate, dry at 60°C, sieve the dry granules with a 16-mesh sieve, and add the prescribed amount of magnesium stearate to the dry granules.

[0029] b.

[0030] Preparation process: pass through a 100-mesh sieve for acarbose, pass through a 80-mesh sieve for sodium carboxymethylcellulose and lactose, weigh the prescribed amount of acarbose, sodium carboxymethylcellulose and lactose and mix evenly, add 6% PVP An appropriate amount of 95% ethanol solution is granulated, dried at 60° C., and the dry granules are sieved with a 16 mesh sieve, and the magnesium stearate of the prescription amount is ad...

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Abstract

The invention discloses a medicinal composition for treating or preventing the obesity and metabolic syndromes, and belongs to the medicine field. The medicinal composition treats orlistat and acarbose as medicinal active components, so the application amount of orlistat in the medicinal composition is substantially reduced, thereby the risk of the damage of orlistat to the liver of a body is reduced. The medicinal composition has a substantial synergistic effect when the medicinal composition is used for treating or preventing the obesity and the metabolic syndromes, can reduces the diabetes and angiocardiopathy suffering risks of obese patients, and has a wide medical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition for treating or preventing obesity, in particular to a pharmaceutical composition with orlistat and acarbose as active ingredients and its use for treating or preventing obesity and medicinal uses for metabolic syndrome. Background technique [0002] Obesity is a chronic disease. According to the estimation of the World Health Organization, it is the most neglected disease facing mankind at present, but the incidence rate is rising sharply. The incidence of obesity is higher in females than in males, and the incidence increases after the age of 35, and is highest in those over 50 years old. According to statistics of 3496 cases, 10% were obese, and 74% were aged 35-55. Obesity not only affects work, life, and appearance, but more importantly, it is harmful to human health. It has been confirmed that the incidence of diabetes, coronary heart disease, hyperten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K31/365A61P3/04A61P3/00
Inventor 赵志全徐真真王洪臣王潞
Owner LUNAN PHARMA GROUP CORPORATION
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