Coreopsis tinctoria nutt extract and application thereof
An extract, the technology of snow chrysanthemum, applied in the field of snow chrysanthemum extract and its application, snow chrysanthemum extract and its application in the preparation of drugs for the treatment of hyperlipidemia and anti-oxidation, can solve the problem that it is difficult to ensure that the snow chrysanthemum extract Stability and effectiveness of pharmacological efficacy and other issues, to achieve the effect of small drug dosage, stable efficacy and high purity
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Embodiment 1
[0021] Embodiment 1: the preparation of snow chrysanthemum extract
[0022] Dried snow chrysanthemum (Coreopsis tinctoria, place of origin: Dabancheng, Xinjiang, batch 130501) flowers 1.0kg, 20L 30% ethanol aqueous solution reflux extraction twice, each time 1h, combined the two extracts, filtered, concentrated and recovered under reduced pressure Ethanol, add appropriate amount of water to dilute to 3.0L; choose AB-8 resin column (100cm×10cm i.d., column volume 2.0L / BV), after loading the sample, water 6BV, 10% ethanol 3BV, 75% ethanol 4BV, 95% ethanol 2BV elution, the flow rate is 1.5-2BV / h; the 75% ethanol elution part is collected, concentrated, and dried to obtain 115g of refined snow chrysanthemum total flavonoids extract (XJE). As detected by HPLC, the specific experimental conditions are the same as those in the qualitative and quantitative analysis of flavonoids in Example 5XJE, and the contents of maritin and flavonomarin in the XJE extract are 17.1% and 26.4%, respe...
Embodiment 2
[0023] Embodiment 2: the preparation of snow chrysanthemum extract
[0024] Dried Snow Chrysanthemum Flos 1.0kg was extracted twice through 20 times of 50% ethanol aqueous solution reflux, and all the other extraction and refining methods were the same as in Example 1 to obtain 104g of refined Snow Chrysanthemum Total Flavonoids Extract (XJE). As detected by HPLC, the specific experimental conditions are the same as those in the qualitative and quantitative analysis of flavonoids in Example 5 XJE, and the contents of maritin and flavonomarin in the XJE extract are 24.3% and 18.7%, respectively.
Embodiment 3
[0025] Embodiment 3: the preparation of snow chrysanthemum extract
[0026] 1.0 kg of dried snow chrysanthemum was extracted twice through reflux of 20 times of 75% ethanol aqueous solution, and all the other extraction and refining methods were the same as in Example 1 to obtain 104 g of refined snow chrysanthemum total flavonoids extract (XJE). As detected by HPLC, the specific experimental conditions are the same as those in the qualitative and quantitative analysis of flavonoids in Example 5 XJE. The contents of maritin and flavonomarin in the XJE extract are 26.1% and 11.5%, respectively.
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