938 results about "Treatment field" patented technology

Manufacturing methods are provided to build modulated medical devices and segments of the devices for applications in the field of intraluminal intervention, reconstruction, or therapy. The methods, comprise steps of metal injection molding and processes of modulation, improve the manufacturability of the devices and / or expand the design alternatives for the devices. The modulated medical devices and their segments, made from the present method inventions, enhance the versatility in intraluminal treatments.

A radiotherapy apparatus includes an irradiation head section, an X-ray source section and a sensor array section. The irradiation head section irradiates therapeutic radiation to a therapeutic field of a target substance. The X-ray source section irradiates diagnostic X-rays to the therapeutic field of the target subject. The sensor array section detects the diagnostic X-rays which have transmitted the target subject, and outputs diagnostic X-ray image data based on the detected diagnostic X-rays. The sensor array section moves in conjunction with movement of the irradiation head section.

A small tabletop stationary five-degree of freedom device such as a “robot” is used to define the treatment region by tracing the region under direct visualization and then to precisely deliver the treatment plan created by an automatic planning system by positioning a single low energy radiation source, or a plurality of low energy sources connected to each other in a predetermined parallel or similar geometry, each source equipped with blocking and attenuation mechanisms, at a plurality of positions in a planar fashion across or through a selected treatment field, thereby delivering a plurality of parallel overlapping beams indexed on a millimeter or submillimeter grid such that a concentration of dose is achieved at a variable depth in tissue relative to the dose where the radiation first enters the tissue and can be used to treat regions on or below the surface of tissue, in a cavity and underlying region created following a surgical resection, on or below the surface of an internal cavity, hollow viscus, or lumen, or deep in tissue adjacent to an inserted probe or conduit or catheter. By generating a plurality of overlapping beams indexed on a millimeter or submillimeter grid that converge on a target volume loaded with gold nanoparticles, a tumorcidal dose of radiation can be delivered in as little as a single session to tumor cells but not to normal cells within or outside the treatment volume. This approach also makes it possible to deliver serial radiosurgical treatments.

20,23-disubstituted mycaminosyltylonolide derivatives and use of the same in the field of the prophylaxis and treatment of pasteurellosis are disclosed. The di-substituents are peperidino optionally substituted with one or two methyl groups. The derivatives have selective antibacterial activity against Pasteurella.

The invention relates generally to the field of cancer prognosis and treatment. More particularly, the present invention relates to methods and compositions that utilize a particular panel of gene products (“biomarkers”) and their differential expression patterns (“expression signatures”), wherein the expression patterns correlate with responsiveness, or lack thereof, to chemotherapy treatment. The invention is based on the identification of a specific set of biomarkers that are differentially expressed in chemotherapy-treated tumors and which are useful in predicting the likelihood of a therapeutic response, including residual disease persistence and subsequent tumor recurrence in cancer patients receiving chemotherapy. The gene panel is also useful in designing specific adjuvant modalities with improved therapeutic efficiency. Also disclosed are methods for characterizing tumors according to expression of the biomarkers described herein.

S-band, C-band or X-band microwave powered linear accelerators capable of delivering therapeutic photon and electron beams are mounted to a gantry with extensions to hold multiple accelerators and are combined with a kV CT for 3-D conformal—IMRT and IGRT to treat a patient by SSD or SAD methods and in a full circle. The invention's tertiary collimator system consists of semi-automated reusable custom field shaping with tungsten powder or melted Cerrobend blocks. The beam's intensity modulation is by means of simultaneous but independently operating multiple accelerators. This system's multiple accelerators enable to avoid interrupted subfractionated radiation therapy to each treatment fields. Hence its effective dose rate at the tumor site is high. The improved radiobiology reduces the total radiation dose to treat a tumor, reducing the incidence of developing second primary tumors is also minimized.

The present invention relates generally to the field of treatments for nasal congestion, and in particular, to a method and apparatus for alleviating nasal congestion in a patient by mechanically stimulating the sneezing reflex in the patient to urge drainage of the nasal passageways. The method includes inserting an instrument having a work tip portion provided with at least one filament into the nostril of the patient. The nasal mucosa of the patient is then probed with the at least one filament to stimulate in the patient the sneeze reflex. This probing action causes the patient to sneeze. With the patient's mouth closed, the sneeze urges at least one of mucus, fluid and debris in the nasal passages of the patient to be forcibly expelled through the nostrils of the patient thereby draining the nasal cavity of the patient. The instrument used in the performance of this method includes a handle portion upon which the work tip portion is carried. The handle portion may be integrally formed with the work tip portion or releasably attachable thereto. The instrument is further provided with a physical stop associated with one of the work tip portion and the handle portion to prevent injury resulting from the working tip portion being inserted too deeply into the nasal passages of the patient.

A medical accelerator system is provided for simultaneous radiation therapy to all treatment fields. It provides the single dose effect of radiation on cell survival. It eliminates the inter-field interrupted, subfractionated fractionated radiation therapy. Single or four beams S-band, C-band or X-band accelerators are connected to treatment heads through connecting beam lines. It is placed in a radiation shielding vault which minimizes the leakage and scattered radiation and the size and weight of the treatment head. In one version, treatment heads are arranged circularly and connected with the beam line. In another version, a pair of treatment heads is mounted to each ends of narrow gantries and multiple such treatment heads mounted gantries are assembled together. Electron beam is steered to all the treatment heads simultaneously to treat all the fields simultaneously. Radiating beam's intensity in a treatment field is modulated with combined divergent and pencil beam, selective beam's energy, dose rate and weight and not with MLC and similar devices. Since all the treatment fields are treated simultaneously the dose rate at the tumor site is the sum of each of the converging beam's dose rate at depth. It represents the biological dose rate. The dose rate at d-max for a given field is the individual machine dose rate. Its treatment options includes divergent or pencil beam modes. It enables to treat a tumor with lesser radiation toxicities to normal tissue and higher tumor cure and control.

A medical accelerator system consisting of coplanar and non-coplanar beams, on line magnetic resonance anatomic and functional imaging and cone beam computed tomographic imaging for single session image guided all field simultaneous radiation therapy and radiosurgery is provided. This system enables single session simulation, field-shaping block making, treatment planning, dose calculations and treatment of tumors. The radiation exposure time to the tumor and the normal tissue is reduced to a few seconds to less than a minute. In filed intensity modulated radiation is rendered by combined divergent and pencil beam, multiple smaller fields within a larger field, selectively varying beam's energy, dose rate and beam weight. Since all the treatment fields are treated simultaneously the dose rate at the tumor site is the sum of each of the converging beam's dose rate at depth. This super-high biological dose rate impairs the lethal and sublethal damage repair.

A system, method, apparatus, and means for delivering treatment fields includes identifying a sequence group. A type of radiation to be applied in a first field of the sequence group is identified. The type of radiation is selected from among primary photon radiation and primary electron radiation. A radiation therapy treatment device is configured, based at least in part on the type of radiation. The first field is then delivered.

The present disclosure relates to the field of endovascular treatment. More particularly, the present invention uses a modified hydrogel intrasaccular occlusion device designed to implement an endovascular treatment to ameliorating or eliminating aneurysm recurrence, which hydrogel may optionally be impregnated with pharmaceutical compounds. The present invention also teaches the use of thin hydrogel coatings to ameliorate endovascular treatment related difficulties.

The present invention provides improvements in the feedback and control systems employed in the field of ventilation therapy. In particular, a system for delivering a supply of gases to a patient is described which incorporates a detachable cartridge or open tubular section (22) used to house a mechanism (11) which senses the humidity, temperature, flow and other attributes of the flowing gas. Information obtained from the sensor may be used to provide feedback to a controller (9) which controls the humidification mechanism in order to provide optimally humidified gases to a patient (1). It will be appreciated that the feedback and control system as described in the preferred embodiment of the present invention can be used in respiratory care generally or with a ventilator.

The invention discloses an integrated up-flow reactor and an advanced treatment method of fermentation industrial effluent, belonging to effluent treatment field. The upper part of the reactor is an aerobic fluidized bed system, the lower part is an anaerobic filter system, the intermediate transition zone is designed to be a connecting part which has a tri-phase separation function and organically combines the upper part and the lower part together. In the reactor, the concentration of biological solid is high and the retention time of biological solid is long, therefore the reactor is suitable for treating secondary biochemical treatment effluent of fermentation industrial effluent which has high salinity and is difficult to be biodegraded; sludge output of each system is low, and the residual sludge generated in the aerobic zone enters to the transition zone and the anaerobic zone to be further treated, the overall sludge output of the reactor is low, and simultaneously, the reactor contains rich biological species which act on organics difficult to be degraded jointly and promote the degradation thereof. The integrated reactor has low energy consumption, less land occupation, convenient operation, load impact resistance and high treatment efficiency, thereby being applicable to the advanced treatment of fermentation industrial effluent.

The invention provides a method for plastically manufacturing a high-purity magnesium alloy absorbable stent, relating to a metal stent manufacturing method for the field of intravascular interventional treatment. The method solves the problem of angiosclerosis caused by low yield strength, poor plasticity, poor corrosion resistance and easy damaged cells existing in the prior absorbable stent. The method comprises the following steps: preparing a high-purity Mg-Al-Zn or Mg-Zn-Ca alloy ingot; refining crystalline grains through heat extruding, warm extruding and cold extruding; machining an alloy blank which is extruded for three times into a tube blank; processing the tube blank by multi-pass cold drawing process on the tube blank; machining the thin walled tube into a stent; putting thestent into fluid polishing solution for fluid polishing and burr removing. The method greatly improves the corrosion resistance, yield strength and plasticity, meets the clinical requirement on resorbing speed and time of the intravascular stent, and eliminates the problem of angiosclerosis; and the compositions of the high-purity magnesium alloy stent have higher safety and reliability.

The invention relates to a medical high-sensitivity micro needle array electrode which is an electrode product integrating an electrode and a micro needle. The micro needle penetrates into skin to reduce the skin resistance and realizes the dry acquisition or the input of stimulating signals or matters. The medical high-sensitivity micro needle array electrode has the characteristics of high efficiency, zero pains and the like. Through the medical high-sensitivity micro needle array electrode, the acquisition quality and the acquisition speed of the signals can be improved, the signal to noise ratio can be improved, and the sensitivity of the signal can also be improved by utilizing additional drugs and supporting matters to be favorable for improving the relevant process treatment effect and accelerating the disease curing time. The product can be subjected to body index long-time monitoring and detection through program design and set according to the practical demands of the patient and other relevant crowds and can also be treated according to the stimulation of the signals acquired and inputted at intervals as required. The medical high-sensitivity micro needle array electrode can be used for phototherapy, electrotherapy, acupuncture and moxibustion, ultrasonic wave and other treatment fields. The high-sensitivity micro needle array electrode is described in structural design and implemented key technology and has a wide application prospect.

The present invention relates to compositions that enhance the intracellular delivery of polynucleotides. The present invention is applicable to the fields of gene therapy and oligonucleotide or DNA therapy. Synthetic methods are disclosed, wherein a polynucleotide can be incorporated into the PEG shielded micelle particle to facilitate the delivery of the polynucleotide across a cellular membrane. Incorporation of the polynucleotide into the shielded micelle particle is provided by covalent and non-covalent means. Other cell targeting agents are provided that may also be covalently coupled to the shielded micelle particle to enhance localization in the body. The compositions herein are suitable for pharmaceutical use but are also suitable as transfection agents for in-vitro or in-vivo research. The PEG shielded polynucleotide micelles can provide favorable pharmacokinetic properties such as enhanced uptake into cancer cells, stability against nucleases, high solubility, and non-binding to serum proteins. The invention comprises a novel gene carrier which is shown to be substantially non-toxic and is suitable for parenteral, oral, pulmonary, and transmucosal delivery of polynucleotides.

The invention relates to the field of gene therapy, in particular relates to sgRNA (singleguide Ribonucleic Acid), as well as a lentiviral vector constructed by the same and application thereof and specifically relates to sgRNA with SIVmac1A11 lentivirus as a framework to express SpCas9 protein and gene specificity. The sgRNA is applied to treating human and simian AIDS (Acquired Immune Deficiency Syndrome). A nucleotide sequence of the sgRNA is shown as SEQ ID NO.1 to 2. According to the sgRNA disclosed by the invention, a current most efficient CRISPR / Cas9 gene editing tool is utilized, a designed CXCR4 / CCR5 gene sgRNA locus has gene knockout activity superior to other loci reported by existing research, and the sgRNA is applied to gene therapy of SIV infected rhesus monkeys for the first time. Compared with ZFN and TALEN, the sgRNA has the advantages of being convenient to operate, low in cost and the like.

The invention relates to a device and a method which are used for removing phosphor and organic matter in an electric flocculation film bioreactor, and belongs to the wastewater treatment field. The device uses the combination technology of the electric flocculation and the film bioreactor, that is, an iron plate or an aluminium plate is adopted to be used as an anode electrode, a plate electrode is electrolyzed to generate iron ions or aluminium ions which are combined with hydroxyl ions and phosphate radical ions in wastewater to form a flocculation body. The organic matter is degraded by microorganism in the film bioreactor to form mud, and the contamination is removed by the filtering of a micro filter membrane component, thereby the purpose of removing the phosphor and the organic matter from the wastewater is achieved. The device has the advantages of simple structure, no chemical agent put, simple operation and management, easy realization of automatic control, as well as good and stable yielding water quality, and is particularly suitable for departments, organizations, schools, building sites and subdistricts in areas lacking of water; the yielding water can be directly used as gray water, reuse water and landscape water.

The present invention relates generally to the field of prophylaxis and therapy for inflammatory and / or fibrotic diseases which include responses to injuries. In particular, the present invention is related to agents that can bind or complex copper such as thiomolybdate, and to the use of these agents in the prevention and treatment of inflammatory and / or fibrotic diseases. Exemplary thiomolybdates include mono-, di-, tri- and tetrathiomolybdate; these agents are administered to patients to prevent and / or treat inflammatory and / or fibrotic diseases, such as pulmonary disease including pulmonary fibrosis and acute respiratory distress syndrome, liver disease including liver cirrhosis and hepatitis C, kidney disease including renal interstitial fibrosis, scleroderma, cystic fibrosis, pancreatic fibrosis, keloid, secondary fibrosis in the gastrointestinal tract, hypertrophic burn scars, myocardial fibrosis, Alzheimer's disease, retinal detachment inflammation and / or fibrosis resulting after surgery, and graft versus host and host versus graft rejections.

The invention relates to an Ag3PO4 / Mg-Al LDO (Layered Double Oxide) visible light composite photo catalyst, preparation and application thereof. The photo catalyst comprises Ag3PO4 nanometer particles and magnesium-aluminum double metal oxides Mg-Al LDO with a mass ratio of 1:10 to 5:1. A preparation method comprises the following steps of: dispersing magnesium-aluminum layered double hydroxides obtained by a co-precipitation method into the solution of soluble phosphate, adding a silver nitrate solution, stirring for 4-24 hours, washing and roasting to obtain the Ag3PO4 / Mg-Al LDO visible light composite photo catalyst. The photo catalyst is applied to degrading and removing of anion pollutants in dye waste water. While maintaining the characteristic of strong adsorptive property of an adsorbent, the Ag3PO4 / Mg-Al LDO visible light composite photo catalyst also has higher visible light catalytic activity so as to have good application prospect in the purification and treatment field ofthe dye waste water; and the preparation technology and production equipment are simple, environmentally friendly, and easy for industrial production.

The invention relates to a preparation method for polydopamine-coated polyethyleneimine-stablized gold-nanometer-star photothermal treatment agent. The preparation method comprises the following steps: preparing a gold seed solution from chloroauric acid and sodium citrate; activating mercaptoacetic acid with EDC, then adding an aqueous PEI solution and carrying out a reaction, dialysis, cooling and drying so as to obtain PEI-SH; adding dopamine hydrochloride into a Tris buffer so as to obtain dopamine Tris buffer; adding the gold seed solution into a chloroauric acid solution, adding a AgNO3 solution and an ascorbic acid solution under stirring, adding PEI-SH after stirring reaction and carrying out a reaction so as to obtain AuNSs-PEI; and adding AuNSs-PEI into the dopamine Tris buffer and carrying out stirring and centrifugation so as to obtain the photothermal treatment agent. The preparation method has the advantages of simplicity, mild reaction conditions, easy operation and industrialization prospects; and the prepared star-like nanometer agent has application potential in the fields of CT imaging diagnosis and photothermal treatment of cancers.

The invention relates to a comprehensive treatment method of high-sulphur high-COD (Chemical Oxygen Demand) caustic sludge waste liquid. The comprehensive treatment method comprises the steps of: 1, acidizing high-sulphur high-COD caustic sludge waste liquid by using an N2 / SO2 mixed gas, when the pH value of the waste liquid reaches 2-6, stopping acidizing; 2, sending tail gas discharged in the acidizing process in the step 1 to a sulphur production device for preparing sulphur; 3, settling the waste liquid generated in acidizing treatment in the step 1and recovering an oil phase; 4, further reducing the COD of the waste liquid by adopting an extraction method when the COD of the waste liquid after the oil phase is separated in the step 3 is always high; and 5, regenerating the waste liquid extracted in the step 4 by using lime. The comprehensive treatment method is low in investment, is mild in operation conditions, is capable of recycling the caustic sludge waste liquid, avoiding the impact of the high-concentration wastewater on a wastewater treatment field, is also capable of recovering sulfide and crude carbolic acid from the caustic sludge waste liquid, and has a certain economic benefit.

The present invention concerns the field of gene therapy and in particular the use of specific adenoviral vector systems for gene therapy, said vector systems offering enhanced efficiency and specificity for gene delivery. More specifically, the present invention provides replicating-competent adenoviral vector systems carrying one or more inserted heterologous gene. The adenoviral vectors system according to the invention are characterized by high binding efficiency and infectivity to cells of neural origin, endothelial cells, carcinoma cells and dendritic cells.

The invention is applicable on the image treatment field, which provides a method, a system and a picture pick-up device for adjusting white balance, wherein the method comprises the following steps switching a image data of a RGB format into a image data of a YCbCr format, estimating the color temperature information of reference white points in images, calculating the gain of channels of R, G and B according to the effective color temperature information, and using the gain of channels of R, G and B to adjust the pixel values of R, G and B in the images. The invention estimates the availability of the color temperature of the reference white point during the white balance adjustment and adjusts the white balance according to the effective color temperature information, which can improve the efficiency and accuracy of the white balance adjustment.

The invention discloses a multifunctional comprehensive treatment platform, comprising a main machine (1), an articulated arm (2) and a treatment head (3), wherein one end of the articulated arm (2) is connected with the top of the main machine (1), the other end of the articulated arm (2) is provided with the treatment head (3), and the treatment head (3) is a UVB (ultraviolet b) treatment head, or a UVA1 (ultraviolet a1) treatment head, or a high-energy red light treatment head, or an integrated optical source treatment head, or an onychomycosis treatment module or a laser anti-obesity treatment head. The platform uses a rotation fixing device to install and fix different treatment heads with various purposes and has the advantages that on one hand, the disassembly and the assembly are convenient, the connection is reliable, and the replacing is convenient and fast; and on the other hand, the function that one main machine can be equipped with various treatment heads with different functions, the treatment field is wide, a great deal of space is saved for the placement of equipment, and the cost of a hospital or a beauty institution is greatly reduced.

The invention relates to water treatment field, in particular to a process of advanced treatment and recycle of urban sewage, which adopts a membrane bioreactor and inverse penetration in combination. The invention takes secondary effluent of urban sewage treated by sewage plant or water of urban sewage being treated to meet the standard of secondary effluent as raw water; the raw water enters the membrane bioreactor MBR system for biochemical pretreatment to remove BOD, COD, SS, ammonia and nitrogen in the water to ensure that the water after treatment meets the quality requirement of reverse osmosis feed water; further water desalination is carried out through reverse osmosis system, and the needed recycle water can be obtained. By adopting MBR technology, removal rate of the main contamination COD can reach over 95 percent, the suspended matter and turbidity of the treated water are close to zero and the quality of the treated water is good and steady; according to process requirements, the water treated by the MBR system and the reverse osmosis system in sequence can be used as cooling water of cold rolled steel, after being blended according to certain proportion, thus realizing recycling of sewage.