The invention aims to provide an
artemisinin-
coumarin heterozygous molecule, a method for preparing the same and application of the
artemisinin-
coumarin heterozygous molecule, provides pharmaceutically acceptable salt, solvate, an optical isomer or a polymorphic substance of the
artemisinin-
coumarin heterozygous molecule and further provides a
medicine with a derivative or salt of the derivative. The derivative or the salt of the derivative is an
active ingredient of the
medicine. Structural formulas of compounds or the pharmaceutically acceptable salt, the solvate, the optical isomer or the polymorphic substance are shown as a formula (I), wherein an L in the formula represents O, O(CH<2>)<n>O, the n is equal to 0-3, and an R1 and an R2 in the formula independently represent
hydrogen atoms,
halogen, hydroxyl, C1-C10 carboxyl, C1-C10 ester, cyan, nitro, C1-C10
alkyl, C1-C10 alkoxy, C3-C7 naphthene, halogenated C1-C10
alkyl and halogenated C1-C10 alkoxy.