43 results about "Triple combination" patented technology

There is provided an extended release pharmaceutical composition comprising from about 200 mg to about 1000 mg of entacapone or salts thereof, optionally with other pharmaceutically acceptable excipients. The invention also provides an extended release pharmaceutical composition comprising triple combination of from about 30 mg to about 300 mg of levodopa, 10 mg to about 100 mg of carbidopa and 200 mg to about 1000 mg of entacapone or salts thereof, optionally with other pharmaceutically acceptable excipients. The invention also relates to process of preparation of such compositions.

This invention pertains to a multi-layered tablet for a triple combination release of active agents to an environment of use. More particularly, the invention pertains to a multi-layered tablet (1) comprising two external drug-containing layers (2 and 3) in stacked arrangement with respect to and on opposite sides of an oral dosage form (4) that provides a triple combination release of at least one active agent. In one embodiment of the invention the dosage form is an osmotic device. In another embodiment of the invention the dosage form is a gastro-resistant coated core. In yet another embodiment of the invention the dosage form is a matrix tablet. In a different embodiment the dosage form is a hard capsule.

The invention discloses a smoke purifying and residual heat deep recycling integrated device, which comprises a purification and heat exchange tower, a smoke system and a heat exchanger, wherein the inside of the purification and heat exchange tower is partitioned into a spraying chamber at the lower part and a filling chamber at the upper part by a wind cap layer; the spraying chamber comprises a spraying layer and a water pool; the water pool is connected with a water supply system, a water treatment pump, a water quality treatment system and a water circulation pump respectively; the outlet of the water circulation pump is connected with the heating hot water inlet of the heat exchanger; the outlet of the water pool is connected with the spraying layer; a smoke inlet is formed in the tower wall above the water pool; the filling chamber comprises a slurry distribution layer, a filling layer, a slurry pool and a slurry supply device; the slurry pool is connected with a slurry treatment pump, a slurry treatment system and a slurry circulation pump; the outlet of the slurry circulation pump is connected with the heating slurry inlet of the heat exchanger and the outlet of the slurry pool is connected with the slurry supply device. The smoke purifying and residual heat deep recycling integrated device is applicable to comprehensive treatment of tail smoke in gas heating, power and cooling triple combination distribution type systems, natural gas boilers, gas-steam combined circulation and fuel power stations.

The invention provides a technical proposal of a public key encryption and decryption method and belongs to a multivariate public key cryptographic system. The encryption is provided by triple combination of reversible linear transformation, reversible nonlinear transformation and reversible linear transformation, and only two reversible linear transformations are necessary to be mastered as a private key at decryption. The method is a substantial improvement of a Matsumoto-Imai cryptographic system, and the new proposal can help effectively resist attack methods such as differential attack, linearization attack and the like. The method also follows the advantages of high efficiency, no cryptographic processor, and being especially suitable for smart cards and the like of the multivariate public key cryptographic system. The advantages of the multivariate public key cryptographic system, particularly resistance of attacks by a quantum computer, can not be compared by those of the traditional public key cryptographic system. Once the quantum computer is practically used, the proposal can be used for replacing the traditional public key cryptographies such as RSA, ECC, ELGamal and the like. The invention further provides a safe and efficient digital signature method based on the public key encryption and decryption method.

This invention provides, in non-limiting embodiments, novel preparations of chelating agents encapsulated in micelles or liposomes comprising the triple combination of: 1) micelles or liposomes comprising alpha lipoic acid or a derivative thereof and 2) micelles or liposomes comprising a chelating agent, such as EDTA; and furthermore, in different embodiments, optionally 3) magnesium chloride. The micelles or liposomes may be comprised of what have been termed “essential phospholipids”.

The invention belongs to the application training equipment of the Internet of Things, in particular to an application training system of the Internet of Things, which at least includes an open triple combination operation console, an application training unit of the Internet of Things, a network wiring terminal connection training unit, and an integrated wiring installation The training unit, the network server and the terminal computer are characterized in that: the open triple combination operation platform is an all-steel structure, including a top hat, a column, a keyboard platform, a bracket, and a base, and 6 columns are fixed on the base at vertical intervals , the top cap is fixed on the column to form a triple combined rack structure, the keyboard table is installed on the front, the spacing between the columns is the same as that of the standard communication pallet, and 4 screw-hole plates are installed on the back of the console. There are multiple rows of screw holes for installing equipment on the top, and there are threading holes and screw holes on the side of the top cap and column. It can cultivate students' hands-on ability, master the application technology of the Internet of Things, and improve the professional skills of students in the Internet of Things.

The addition of a selective, fast-acting, short half-life CDK 4 / 6 inhibitor in a very specific dosage regimen to the combination of chemotherapy with a checkpoint inhibitor provides superior results in the treatment of a tumor or cancer. The unexpected discovery is that the short pulsatile specifically-timed administration of a selective, fast-acting, short half-life CDK 4 / 6 inhibitor during administration of the chemotherapy portion of the triple combination therapy has a profound effect on the immune cells in the cancer microenvironment.

In alternative embodiments, the invention provides a “triple combination” therapy for treating, ameliorating and preventing Crohn's Disease (or Crohn syndrome, terminal or distal ileitis or regional enteritis) or related disorders and conditions in mammals, such as paratuberculosis in mammals, or Johne's disease, including genetically-predisposed and chronic disorders, where the microbial or bacterial flora of the bowel is at least one causative or symptom-producing factor; and compositions for practicing same. In alternative embodiments, methods and compositions of the invention comprise or comprise use of therapies, medications, formulations and pharmaceuticals comprising active agents that can suppress or eradicate the microbiota super-infection that causes Crohn's Disease or paratuberculosis infection in mammals. In alternative embodiments, the methods and uses of the invention for treating, ameliorating and preventing Crohn's Disease and complications of Crohn's Disease, or related disorders and conditions in mammals, such as paratuberculosis in mammals, or Johne's disease, comprises administration to an individual (human or mammal) in need thereof: (1) an anti-TNFα composition, or a composition capable of down-modulating TNFα activity; (2) a Hyperbaric Oxygen Treatment, or HBOT; and (3) an anti-Mycobacterium avium sub species paratuberculosis (MAP) (an anti-MAP) agent, composition or therapy.

The handcuffs disclosed by the present invention include a swing arm with three rows of claws and a backstop member with three rows of ratchet protrusions corresponding to the three rows of claws, which can prevent suspects from illegally releasing the combination between the claws and the ratchet protrusions . The ratchet protrusions and boom pawls are triple combined so that even if a suspect illegally opens the handcuffs using a thin pin or other external thin piece along the boom receptacle on the side or underside of the body, it will only work if the ratchets are all released at the same time. The handcuffs can only be forcibly opened when there are three or more combinations between the tooth protrusions and the claws of the boom. Therefore, in fact, it is impossible to illegally open the handcuffs, therefore, the illegal opening of the handcuffs is fundamentally prevented.

The invention discloses a human DC-CIK immunocompetent cell. The human DC-CIK immunocompetent cell is characterized by being loaded with the vaccine oncolytic gene virus Oncopox-IL-24, wherein the vaccine oncolytic gene virus Oncopox-IL-24 is obtained through fusion of the vaccine oncolytic virus and the IL-24 gene, the IL-24 gene is inserted into a TK enzyme gene region of the vaccine oncolytic virus, and the human DC-CIK immunocompetent cell is obtained through co-culture of the vaccine oncolytic gene virus Oncopox-IL-24 and a DC-CIK immunocompetent cell. The human DC-CIK immunocompetent cell combines the advantages of the oncolytic virus, cell factors and immune cells to realize an efficient broad-spectrum tumor killing effect through cooperation, the tumor cell killing activity of the human DC-CIK immunocompetent cell is over 160 times higher than that of DC-CIK, inhibition of a neutralizing antibody on tumor cell invasion of the oncolytic virus is avoided during blood circulation, the in-vivo curative effect of the oncolytic virus is improved, the side effect of the oncolytic virus is reduced, and a new direction is provided for developing efficient and safe clinical antitumor immunity cell therapy techniques or drugs.

The present invention relates to a method for treating metastatic breast cancer in an individual comprising administering to an individual in need thereof a dosing regimen which comprises administering to the individual nonpegylated liposomal doxorubicin, a taxane and a HER2 / neu receptor antagonist, wherein the individual previously has been administered an anthracycline.

Topical application of a triple combination immixture of fluocinolone acetonide, tretinoin and hydroquinone is useful for the maintenance therapy of melasma to prevent hyperpigmentation recurrence or reduce the severity of the hyperpigmentation recurrence.

The invention discloses a flexible positioning mechanism for white vehicle body assembly welding. The mechanism comprises a base; a first cover plate is arranged on the surface of the base; a triple combination element is arranged in the first cover plate; a second cover plate is arranged beside the first cover plate; an electromagnetic valve is arranged in the second cover plate; an electric appliance signal module mounting bracket is mounted on the surface of the base; fixing mechanisms are uniformly distributed on the bottom surface; the fixing mechanisms comprise pressure bearing plates fixed through bolts; vertical support plates are arranged on the pressure bearing plates; support plates for supporting the base are arranged on one sides of the vertical support plates; the support plates are fixedly connected with the pressure bearing plates through bolts; a servo flexible positioning device is arranged on the surface of the base; a reciprocating rod mechanism is arranged at the middle part of the surface; and a vehicle body carrying flexible positioning mechanism is mounted on the reciprocating rod mechanism. Through support by the flexible positioning mechanism, the production efficiency is improved, the vehicle body welding position can be effectively fixed, and the carrying time is greatly shortened; and the mechanism has the characteristics of simple operation and good fixing effect.

The invention features new a method for treating inflammatory bowel disease, including Crohn's Disease (CD) or ulcerative colitis in a human patient, comprising administering to a patient a combination therapy comprising an anti-α4β7 antibody, a TNFα antagonist, and an immunomodulator.

The invention discloses a non-oil-stick triple-combination piston oil ring and a fabrication method thereof. The surfaces of a bushing ring and a scraper are subjected to ultrasonic cleaning and then phosphating; a thin phosphate layer is formed on the surface of a ring body; then, a non-oil-stick coating is sprayed; and a dense non-oil-stick coating is formed on the surface of the bushing ring and the scraper by drying and solidifying. The non-oil-stick coating consists of molybdenum disulfide and polytetrafluoroethylene; after the non-oil-stick coating is sprayed on the surface or the surfaces of the bushing ring or the bushing ring and the scraper, the liquidity of lubricating oil on the surface of the ring body is improved, the problem that carbon is easily formed on the surface of the existing triple-combination oil ring to result in high oil consumption is solved, the oil consumption is lowered, and an engine can be energy-saving and environment-friendly truly.

The invention provides a wastewater reuse process and device. The wastewater reuse process comprises the following steps: S1, wastewater is fed into a triple-combination concentration tank; S2, flow-out wastewater enters a CMF (continuous membrane filtration) treatment system for primary filtering treatment; S3, wastewater collected in a CMF water production tank flows through an active carbon filter and a cartridge filter sequentially for secondary filtering treatment; S4, wastewater subjected to secondary filtering treatment is treated in a reverse osmosis device and flows into a reverse osmosis production tank. The wastewater reuse process and device have the following advantages: (1) a small area is occupied, civil engineering investment is small, and a high-density tank, a V-shaped filter tank and a middle water tank are not needed; (2) multi-media, ultrafiltration, matched equipment, chemicals and consumables are omitted, and the cost is lower; (3) reuse treatment of VRLA (valve-regulated lead-acid) battery wastewater is more targeted; (4) effluent is more stable and operation cost is lower by adopting the CMF treatment system instead.

The invention discloses an eyesight-improving paste formula used for myopia and a preparation method thereof. The eyesight-improving paste formula comprises the following components: 5 parts of safflower carthamus, 5 parts of raspberry, 5 parts of Semen Cuscutae, 5 parts of Radix Codonopsis, 5 parts of bighead atractylodes rhizome, 5 parts of cassia seed, 5 parts of Plantain seed, 5 parts of motherwort fruit, 4 parts of pearl, 4 parts of radix pseudostellariae, 5 parts of Radix Astragali, 1 part of Asarum Herb, 0.25 parts of borneol, 10 parts of edible ethanol with content concentration being95%, 0.25 parts of ethylparaben, and the balance of alkylene. Compared with current various myopia treatment modes in the prior art, the problems of long treatment course, slow effectiveness, impermanent effect, inconvenient usage and high technical requirement can be solved. A traditional traditional Chinese medicine is taken as a basis, modern science and technology is combined to prepare a paste agent, a triple combination therapy of acupoint drug application, massage and meridian treatment is used at a periorbital area, the eyesight-improving paste has the advantages of efficient and simple clinical effect, and the persistent effectiveness can be obviously improved.

Topical application of a triple combination immixture of fluocinolone acetonide, tretinoin and hydroquinone is useful for the maintenance therapy of melasma to prevent hyperpigmentation recurrence or reduce the severity of the hyperpigmentation recurrence.

There is provided an extended release pharmaceutical composition comprising from about 200 mg to about 1000 mg of entacapone or salts thereof, optionally with other pharmaceutically acceptable excipients. The invention also provides an extended release pharmaceutical composition comprising triple combination of from about 30 mg to about 300 mg of levodopa, 10 mg to about 100 mg of carbidopa and 200 mg to about 1000 mg of entacapone or salts thereof, optionally with other pharmaceutically acceptable excipients. The invention also relates to process of preparation of such compositions.

The present system and method relates in general to treating warts using a triple combination of therapies contained within a kit. The therapies are easy for a patient to self-apply, eliminating the need for constant physician supervision. The first therapy involves a patient applying a patch within the kit to a wart, which may be in the form of a transdermal patch. The patch may contain a first medicine, such as salicylic acid, and be worn for a period of twelve hours. Once removed, the second therapy involves using an ablative tool to gently slough away the treated wart, said ablative tool being contained within the kit. The third therapy involves applying a second patch, which may contain a second medicine, such as imiquimod, and also be worn for a period of twelve hours. This three step process may be repeated until the wart is fully treated.

The invention discloses a device for increasing the shale gas recovery rate by arc cylinder surface triple-combination energy-gathering fracturing. The device comprises a detonating device and a gas delivery device; the detonating device comprises a triple-combination energy-gathering device, a detonating circuit and an exploder; the triple-combination energy-gathering device comprises a left energy-gathering cover used for gathering explosive exploding energy to emit the energy to the right, a right energy-gathering cover used for gathering explosive exploding energy to emit the energy to theleft, and a middle energy-gathering cover used for gathering explosive exploding energy to emit the energy to the middle; and the left energy-gathering cover and the right energy-gathering cover arearranged to be rotating paraboloids with openings outwards, and the middle energy-gathering cover is arranged to be a cylinder surface with an opening outwards. Compared with the prior art, because ofthe energy-gathering effect of the left energy-gathering cover, the middle energy-gathering cover and the right energy-gathering cover, shale in a fracturing area can be pressed and exploded simultaneously from the three space directions of left, middle and right separately, cracks quickly penetrate to form a shale fracture zone shaped like a Chinese character ge, the superficial area the shale is increased, and therefore the analytical rate and recovery rate of shale gas are effectively increased. A spherical-crown-shaped boss further strengthens the energy-gathering effect.

The invention relates to a triple-combination hydraulic press. The triple-combination hydraulic press comprises a hydraulic system, a locating mechanism, a jacking plate, upright columns, a motor, a machine frame, an oil tank and three power heads, wherein the three power heads are mounted below the jacking plate and are respectively connected with the hydraulic system. According to the triple-combination hydraulic press, three hydraulic power systems can be respectively controlled by one hydraulic control system, so that the time is saved, the production efficiency is increased, the structure is ingenious, the repair is convenient, and meanwhile, the floor area is small.

The invention discloses a novel chain tensioner, and the invention relates to a chain stop device for a scraper conveyor. It includes a cover plate and a pressure plate. The pressure plate is installed in the middle of the cover plate. At least three pin shafts are installed on the surface of the cover plate. The bottom of the chute of the scraper conveyor is provided with a pin hole matching the pin shaft. The two ends of the pressure plate are installed on the Inside the chute. The present invention has the following advantages. 1. When using, combine the three parts of the cover plate, the pressure plate and the pin shaft into a whole, insert them into the limit hole in the chute, use the motor to reverse the direction, and pinch off the remaining chain, so as to achieve the purpose of tightening the chain ; This device has been used on site for more than half a year. The maintenance workers generally report that it is safe and convenient to operate, which reduces the complicated work procedures of the operators, reduces the labor intensity of the workers, and protects the personal safety of the workers. 2. The device is easy to operate, which can help maintenance personnel reduce the time for troubleshooting and improve work efficiency.

A three-combination tool, with a flat-head screwdriver at the lower end of the T-shaped structure, a 14mm casing wrench at the left end, and a 17mm casing wrench at the right end. This three-combination tool combines three tools in one, which is very convenient.

The invention relates to the field of low-voltage line leakage protection, and discloses a low-voltage line electric shock fault judgment method based on a triple combination criterion and a residual current circuit breaker. According to distribution characteristics of residual current in a transformer area, a current harmonic amplitude change rule during an electric shock fault is studied, two indexes of an even harmonic change rate and a power frequency variation are defined, and a combination criterion combining an even harmonic change rate minimum threshold value, a power frequency change quantity threshold value and a residual current setting value is provided. The triple combination criterion provided by the invention is not only suitable for detecting the occurrence of a fault, but also can detect the situation that the fault disappears, when the third-stage line has a fault, the third-stage residual current circuit breaker acts to break the branch line, at the moment, the second-stage residual current circuit breaker detects that the fault disappears after a certain period of time and does not act, and the fault disappears. An electric shock fault can be better identified, frequent maloperation of the residual current circuit breaker is reduced, and a power grid system can operate more reliably.

The invention discloses a super-large span peripheral simply-supported prestressed double-layer and three-layer combined torsional reticulated shell structure, which comprises a torsional reticulated shell (1); framework columns (2) with unequal heights are arranged on the periphery of the torsional reticulated shell (1) according to the column reticulated distance requirement, and a central framework column (3) is arranged in the center of each side of the torsional reticulated shell (1); the overhung parts of the torsional reticulated shell (1) are simply supported at the tops of the framework columns (2); and a prestressed steel cable (4) is arranged on the central framework column (3) in the center of each side of the torsional reticulated shell (1). The combined torsional reticulated shell structure has good structural integrity, the lateral rigidity resistance of the structure is greatly improved, the hidden danger caused by the super-large overhung parts is eliminated, the steel for the structure is further optimized, the consumption of the steel is greatly reduced, and the requirements of 'energy conservation and synergism' are met; and the structure is particularly suitable for a super-large span torsional reticulated shell roof with span of 120 to 180 meters, and is a safe, reasonable, advanced and economic novel structural system.