69 results about "Abietane" patented technology

The invention relates to corydalis and corydalis of isodon macrophylla which are extracted and separated from the isodon macrophylla and have the structural formula of ent-abietane diterpenoids, a preparation method and applications thereof. A plurality of in vitro anti-tumor activity experiments show that the compounds have significant effect of inhibiting the activity of tumor cells and can be applied in the preparation of medicaments for treating cancers and / or tumors. The invention can also provide the lead compounds for developing new medicaments for treating various common multiple cancers, thereby having important significance on developing and utilizing medicinal plant resources of China.

The invention provides a rosin type diterpene derivative as well as a preparation method and application thereof. The derivative is a compound with structure shown in a general formula I, II or III which is shown in the description or an addition salt formed by the compound and an acid or an alkali which is acceptable in pharmacy, wherein R1 is hydrogen, hydroxyl or alkoxy or acyloxy of C1-C3; R2 is saturated or unsaturated alkyl of C1-C3, oxygen-containing alkyl of C1-C3 or acid of C1-C3 and ester or salt of the acid; the derivative is prepared in the way that Clerodendrum bungei as a labiatae clerodendrum plant is used as a raw material and subjected to solvent extraction, and column chromatography separation and purification. According to the invention, on the basis that the rosin type diterpene derivative is obtained through separation, the fact that the compound has the function of suppressing the expression of SREBP is confirmed, a lead compound is provided for developing medicines capable of treating dyslipidemia, and important significance on the development of new application of natural products and botanical drugs is achieved.

The invention relates to a plant cell culture technology, in particular to a method for biosynthesizing abietane diterpenoid compounds by using cephalotaxus fortune culture cells. The method comprises the following steps of: placing cephalotaxus fortune cells in a common culture medium, and culturing, wherein50 to 150g of the cells are inoculated in each liter of wet weight of the culture medium; and adding an inducer at the final concentration of 10 to 2,000 mu M and 50 to 200g of adsorbent into each liter of culture medium at the initial stage of cell exponential growth, wherein the inducer is an abiological inducer or fungal elicitor. The method is a biosynthesis method and is stable and environment-friendly; and products are completely adsorbed onto the adsorbent, so that the operation process of separation and purification is greatly simplified, the cost is reduced and industrial production is easy to realize. Meanwhile, seven abietane diterpenoid compounds comprising a new compound are synthesized. The abietane diterpenoid compounds have high bioactivity, and are important lead compounds, and the technology has important commercial application prospect.

The invention relates to the technical field of medicines, and to abietane type diterpene enantiomer compounds, and a preparation method and application thereof. Specifically, the invention relates to diterpene compounds, i.e., sessilifols F, I and P, and the preparation method and application thereof in preparation of drugs used for treatment of neurodegenerative diseases. According to the invention, Chloranthus sessilifolius is extracted and separated to prepare the novel abietane type diterpene enantiomer compounds, i.e., sessilifols F, I and P, with a structural formula as shown in the specification; and pharmacological experiments show that the diterpene compounds have significant inhibitory activity of nerve inflammation (IC50 is smaller than 10 [mu]M), is free of toxic effect on cell survival, and can be applied in preparation of the drugs used for prevention and / or treatment of the neurodegenerative diseases which comprise, but not limited to, Alzheimer's disease (AD) and Parkinson's disease (PD).

The invention relates to an abietane type diterpene derivative (1-9) shown as a structural formula (I), a medicine composition prepared from the compound 1-9 at the effective treatment quantity and amedicinal carrier, preparation method of the abietane type diterpene derivative (1-9) and the medicine combination, and application thereof to preparation of medicine for treating human diseases, particularly, application as a selective SYK (spleen tyrosine kinase) inhibitor and application to preparation of medicine for treating various diseases mediated by SYK.

The invention provides an abietane type diterpenoid compound with blood lipid lowering activity as well as a preparation method and application of the abietane type diterpenoids compound. Particularly, the compound provided by the invention has a structure shown as the formula I in the description, wherein the definition of all radicals is described in the description. The compound provided by the invention has the activity of increasing low-density lipoprotein intake in vivo or in vitro, and has the potential of being used as novel blood lipid lowering medicine.

The present invention relates to the field of wood rosin and resin acid derivatives and more particularly to abietane-type diterpenoids as well as different uses thereof. Furthermore, the present invention relates to methods of coating surfaces, preventing, reducing or inhibiting bacterial biofilm formation, and treating or preventing disorders caused by microbial growth and viability as well as bacterial colonization.

The invention relates to application of abietane derivatives in the preparation of drugs for the prevention and treatment of cerebral ischemic diseases, and particularly relates to the use of the abietane derivatives in the preparation of the drugs for prevention and treatment of nerve cell injury related diseases including the cerebral ischemic diseases, a cerebral ischemia-reperfusion injury, sequelae of cerebral ischemia, an oxidative stress-induced brain injury and the like. In the evaluation of drug activity, inventors found that the kind of the abietane derivatives has a significant protective effect on an ischemic brain injury, and can be used in clinical application as drugs for neurocyte injury related diseases such as cerebral ischemia.

The invention relates to a compound of 18,19-dedimethyl-3-bis(methylmercapto) methylene-1-4-methyoxyl abietane-8,11,13-triene-4-ketone shown as a formula I1 as below and a midbody thereof. The invention also relates to a preparation method of the compound and application of the compound in the preparation of triptophenolide methyl ether.

The invention discloses an application of abietane type diterpene compounds. The formula of the abietane type diterpene compounds is represented by the formula I. At least one of the compounds represented by the formula I, and hydrates, pharmaceutically acceptable salts, tautomer, stereoisomer, and precursor thereof is taken as an active component to prepare drugs or health care food for inhibiting mast cell de-granulation. The results of experiments show that the compounds represented by the formula I can prominently inhibit mast cell de-granulation, can be used as an active component to prepare drugs or health care food for inhibiting mast cell de-granulation, further can be used as an active component to prepare a mast cell stabilizer, and can be used to prepare drugs or health care food for preventing or / and treating allergic diseases caused by mast cell de-granulation.

The invention relates to the technical field of anti-tumor compounds, in particular to an abietane type diterpenoid compound with an anti-tumor effect, a preparation method, a pharmaceutical composition and application, the chemical name of the abietane type diterpenoid compound is 12, 16-epoxy-17 (15-16)-trans-3, 5, 8, 12-abietane tetraene-7, 11, 14-triketone. The compound is extracted from air-dried branches of the clerodendranthus bracteatus, has an inhibition effect on various tumor cells, particularly has an obvious inhibition effect on human lung cancer cells A549, has a very great application prospect in preparation of antitumor drugs, and has great significance in improvement of medical and economic values of the clerodendranthus bracteatus. The method plays an important role in research on the nutritional value, potential toxicity, biological and pharmaceutical characteristics, chemical components and the like of Clerodendrum bracteatum.

The invention provides a series of open-loop abietane diterpene compounds or pharmaceutical salts thereof, pharmaceutical compositions composed of the compounds as effective ingredients and at least one pharmaceutically acceptable carrier, and a preparation method and an application of the compounds or the pharmaceutical salts thereof in preparation of drugs or functional foods for prevention and(or) treatment of hypertension, heart disease, myocardial ischemia, stroke and other cardiovascular and cerebrovascular diseases. The compounds 1-8 are novel open-loop abietane diterpene compounds, have significant vasodilation activity on KCl preshrunk rat thoracic aorta, have a novel chemical structure, and have many advantages as vasodilation drugs. The compounds 9 and 10 are known compounds, also have significant vasodilating effects on KCl preshrunk rat thoracic aorta, and have no reports in vasodilation at present.

The invention discloses a novel skeleton meroterpenoid compound and its preparation method, pharmaceutical composition and application in anticancer medicines. Abietane-type diterpene and phloroglucinol are connected through an alpha-pyrone unit so that the compound is formed. A pharmacological experiment shows that the compound has significant anti-tumor activity to pancreatic cancer, colon cancer, liver cancer, lung cancer, breast cancer, gastric cancer and esophageal cancer and can be used as an anti-tumor drug in clinical application.

The invention relates to the field of plant secondary metabolites. In order to develop a new natural anti-tumor medicine, the invention provides a diepoxy diterpene compound with an anti-tumor effectas well as a preparation method and application thereof. The chemical name of the diepoxy diterpene compound is 8(9), 12(16)-diepoxy-3, 7-dihydroxy-17 (15->16)-trans-5, 12-abietane diene-7, 11, 14-triketone. The compound is extracted and prepared from clerodendrum griffithianum, has an anti-tumor effect, has an inhibiting effect on various tumor cells such as human lung cancer cells A549, human cervical cancer HeLa cells, human breast cancer Bcap37 cells and human liver cancer SMMC7721 cells, especially has an obvious inhibitory effect on human breast cancer Bcap37 cells, has a very large application prospect in preparation of anti-tumor drugs, and plays an important role in improving the medical and economic values of clerodendrum griffithianum and promoting development and research on the nutritional value, potential toxicity, pharmacological characteristics, chemical components and the like of clerodendrum griffithianum.

The invention provides an abietane diterpenoid compound, a preparation method thereof, a pharmaceutical composition with antiplatelet activity and application thereof and belongs to the technical field of medicines. The abietane diterpenoid compound provided by the invention has remarkable inhibitory activity on arachidonic acid induced rabbit platelet aggregation and obvious in-vivo antithrombotic activity, and the pharmaceutical composition taking an antiplatelet compound as an effective component can be used for preparing a medicine for preventing and / or treating thrombotic diseases and hasa potential clinical application value.

The present invention relates to the technical field of medicine, and discloses the structure, the separation and the identification of a new abietane type diterpene glucoside compound (named tripterycosideA) separated from Tripteryginum Wilfordii Hook. F, and applications of the new abietane type diterpene glucoside compound in preparation of anti-inflammatory drugs.

The invention relates to a semi-synthesis method of abietane diterpene and a derivative thereof, the abietane diterpene derivative and application. Dehydroabietic acid is taken as a raw material, dehydroabietic acid is subjected to six-step reaction such as decarboxylation, allylic oxidation, hydroboration oxidation and alkylation to obtain abietane diterpene triptobenz L, acetic anhydride and cyclopropanecarboxylic acid are respectively selected to be subjected to acetylation and condensation reaction with the abietane diterpene triptobenz L, and the nepetafolin F and a new compound 19-cyclopropanecarboxyl-triptobenz L are respectively generated. The semi-synthesis method provided by the invention is simple and safe to operate, a compound basis is provided for carrying out anti-tumor mechanism experiments, in-vivo pharmacological experiments and pharmacokinetics experiments of the compounds, and the synthesized new compound has a better anti-tumor effect.

The invention relates to honeycomb carbon for efficiently removing TVOC, which comprises special carbon, and the special carbon comprises the following components: 93%-95% of activated carbon powder,1,200-1,500 mg / g of iodine value, 12-18 ml / g of methylene blue, 15% of moisture, 5% of tanshinone and 5% of ash. The special carbon with a unique formula is adopted, the activated carbon powder can purify a certain amount of TVOC through a physical adsorption method, tanshinone serves as a plant source air purification terpene compound, and the effect of purifying indoor air is achieved. Tanshinone is a main fat-soluble active ingredient of traditional Chinese medicine salvia miltiorrhiza in China, and belongs to abietane norditerpene compounds. TVOC is efficiently removed through plant sourceair purification and activated carbon adsorption, the indoor air quality is improved, and the body health of people is guaranteed.

The invention discloses a preparation method of Icetexane type abietane diterpene, which comprises the following steps: S1, adding carnosic acid into a methylation system, carrying out solid-liquid separation, and collecting a solid phase to obtain an intermediate 2; s2, adding the intermediate 2 into a reduction system, carrying out solid-liquid separation, and collecting a solid phase to obtain a prepared intermediate 3; and S3, adding the intermediate 3 into a rearrangement system, carrying out solid-liquid separation, and collecting a solid phase to obtain the Icetaxane diterpene. The synthesis method disclosed by the invention has the characteristics of short reaction time, high selectivity, high yield, large-scale preparation and no protection of key steps, and can be widely popularized and applied.

The invention relates to the technical field of separation and purification of schizonepeta bracteata, in particular to abietane diterpene as well as a preparation method and application thereof. The invention discloses a compound 1,2,3,4,4a,9,10,10a-octahydro-7-isopropyl-2,4a-dimetyl-1-metylenephenanthrane-2, 9-diol (nepetabrate D) for the first time, wherein in-vitro anti-inflammatory and antibacterial pharmacodynamic experiments are carried out on the compound; the experiments show that the compound has a relatively strong inhibition effect on RAW 264.7 cells; therefore, the compound can be applied to preparation of medicines for preventing inflammation and inhibiting bacteria or / and preparation of anti-inflammatory and antibacterial medicines or / and preparation of health-care products for preventing inflammation and inhibiting bacteria.

The invention discloses an abietane compound with a C-ring combined lactone ring novel skeleton, which is prepared by condensing an abietane diterpenoid quinone compound serving as a raw material andanhydride under the action of a metal catalyst. According to the novel abietane compound constructed by the invention, the non-planarity of the compound is effectively improved, the structure is novel, the corresponding biological activity is also remarkably improved, and the compound has greater patent medicine potential.

The invention belongs to the technical field of medicines, and relates to a 90% methanol extract prepared from branches and leaves of Pseudotsuga sinensis, labdane and abietane diterpenoid compounds separated from the methanol extract, a preparation method of the compounds and application of the compounds in pharmacy. A biological activity test shows that the compound remarkably inhibits ATP-citrate lyase (ACL); the compound can be used for preparing medicines or lead compounds of the medicines for preventing or treating ACL-mediated glycolipid metabolism disorder related diseases, such as hyperlipemia, atherosclerosis, non-alcoholic fatty liver disease, type 2 diabetes mellitus and obesity.

The invention relates to the technical field of separation and purification of overground parts of schizonepeta bracteata, in particular to Nepetatide J, a preparation method thereof and application of the Nepetatide J in preparation of drugs for preventing inflammation. The invention discloses the Neepetarate J for the first time, and the Neepetarate J disclosed by the invention has a relatively strong anti-inflammatory effect on RAW 264.7 cells stimulated by lipopolysaccharide (LPS), and can remarkably resist inflammation and inhibit inflammation, so that the Neepetarate J can be applied to preparation of inflammation prevention medicines and anti-inflammatory medicines.

The invention relates to anti Coxsackie virus effective components, which are separated from illicium jiadifengpi B.N.Chang, and comprise six novel abietane diterpene acid (1 to 6) compounds and seven known abietane diterpene acid (7 to 13) compounds, pharmacy-acceptable salts thereof, a preparation method thereof, a pharmaceutical composition containing the compounds, and applications of the compounds in the preparation of drugs for preventing Coxsackie virus.

The invention relates to a gel dressing for wound care and a preparation method thereof. The gel dressing for wound care comprises abietane diterpenes, and has excellent effect in promoting wound healing; especially, a combination of a compound 1 and a compound 3 can effectively shorten the time needed for wound healing, reduce secondary infection of wounds, and can be widely applied to treatment of ordinary wounds or traumatic wounds with self-healing difficulties, such as diabetic foot, burns and scalds.

The invention discloses use of Icetaxane type abietane diterpenes in preparing a medicine for treating colorectal cancer. An action mechanism of the Icetaxane type abietane diterpenes is as follows: a level of chaperonin binding immunoglobulin protein (BiP) in endoplasmic reticulum is up-regulated, a transfer of the BiP from cytoplasm to nuclei is promoted, and cell apoptosis is further induced. The invention further expands a use range of the Icetaxane type abietane diterpene and derivatives thereof.

The invention relates to the technical field of anti-tumor compounds, in particular to a 17 (15 to 16)-trans-abietane diterpenoid compound which is extracted from clerodendrum bracteatum and has an anti-tumor effect, a preparation method, a pharmaceutical composition and application of the 17 (15 to 16)-trans-abietane diterpenoid compound. The 17 (15 to 16)-trans-abietane diterpenoid compound is a natural anti-tumor compound extracted from clerodendrum bracteatum branches, has the biological activity of inhibiting tumor cells, particularly has an obvious cell inhibition effect on human promyelocytic leukemia cells HL-60, has a very great application prospect in preparation of anti-tumor drugs, and has an important effect on improving the medical and economic values of the clerodendrum bracteatum.

The invention discloses the application of Icetexane-type abietane diterpene in the preparation of colorectal cancer therapeutic drugs, and its action mechanism is to up-regulate the level of chaperone protein BiP (Binding immunoglobulin protein) in endoplasmic reticulum, and promote the transfer of BiP protein from cytoplasm to nuclei, thereby inducing apoptosis. The invention further expands the application range of the Icetexane type abietane diterpene and its derivatives.

The invention discloses a method for preparing an Icetexane-type abietane diterpene, which comprises the following steps: S1: adding carnosic acid to a methylation system, separating solid and liquid, and collecting the solid phase to obtain intermediate 2; S2: adding the obtained Add the intermediate 2 to the reduction system, separate the solid and liquid, collect the solid phase to prepare the intermediate 3; S3, add the intermediate 3 to the rearrangement system, separate the solid and liquid, collect the solid phase to prepare the Icetexane type abietane diterpene; the synthesis method of the present invention has the characteristics of short reaction time, high selectivity, high yield, large-scale preparation, and no need for protection in key steps, and can be widely popularized and applied.