1125results about How to "Good anti-inflammatory effect" patented technology

A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a curcuminoid species and an effective amount of a second component selected from the group consisting of an alpha-acid species or a beta-acid species or derivatives thereof. The composition provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.

The invention discloses an emollient lotion for moisturizing skin and controlling oil. The emollient lotion is prepared from the following components in percentage by mass: 0.1-5% of hydrogenated phosphatidylcholine, 0.1-5% of phytosterol, 0.001-1% of ceramide, 0.1-5% of silica, 2-20% of humectant, 2-20% of grease, 0.1-1% of thickening agent, 0.5-5% of emulsifying agent, 0.1-0.6% of preservative and the balance of distilled water. The emollient lotion has efficient moisture retention and can be used for enhancing the protection mechanism of the skin, promoting the metabolism of cell membranes of the skin and achieving the aims of improving dry skin as well as relieving and repairing the skin.

The invention discloses the method for applying active constitutent of Bunge prickly ash to daily used chemical products, wherein the zanthoxylum oil extracted from Chinese prickly ash fruit and the pricklyash peel concrete extracted from the leaf, stem, bark and root of the Chinese prickly ash are used as the active composition, and conventional methods are employed to prepare the line products containing pricklyash peel active compositions.

The invention belongs to the technical field of medicines and particularly relates to a phosphodiesterase-4 inhibitor as shown in a general formula (I) and a pharmaceutically acceptable salt, a stereoisomer or a solvent compound thereof. In the formula, R1, R2, R3, R4, R5, R6, R7, R8, R9, R7', R8', R9', L and a ring A are as defined in the specification. The invention further relates to a preparation method for the compound, a pharmaceutical composition with the compound, and an application of the compound and the pharmaceutical composition to preparation of drugs for treating and / or preventing inflammatory diseases, disease symptoms and disease conditions characterized by or related with undesired inflammatory immune reaction and all diseases induced by or related with TNF-alpha (tumor necrosis factor-alpha) and PDE-4 (phosphodiesterase-4) hypersecretion.

The present invention provides an ophthalmic aqueous pharmaceutical preparation, which is excellent in anti-inflammatory effect, which is less stimulative and which has high safety and excellent storage stability. The ophthalmic aqueous pharmaceutical preparation comprises meloxicam and trometamol.

A compound of the formula (I):wherein R is hydrogen or C2-6 alkanoyl; X is halogen; and ring A is benzene ring which is optionally substituted by 1 to 4 substituents selected from {circle around (1)} halogen, {circle around (2)} hydroxy, {circle around (3)} C1-6 alkoxy optionally substituted by halogen or phenyl, {circle around (4)} C1-6 alkylthio optionally substituted by halogen or phenyl, {circle around (5)} C1-6 alkyl optionally substituted by halogen, {circle around (6)} C2-6 alkanoylamino or {circle around (7)} carboxy optionally esterified by C1-6 alkyl, or a salt thereof; which can be used for preventing or treating inflammatory disease, arthritis, chronic rheumatoid arthritis, autoimmune diseases, or rejection after organ transplantation.

The present invention provides a helical soft capsule. Every capsule contains 5-200mg of helical, the rest is solvent matrix, the described solvent matrix is one of PEG 300-1000, propylene alcohol, soybean oil and peanut oil or their composition. According to the requirements the medicinal color matter and flavor agent can be added into its liquid medicine. Said invented soft capsule has the sedation, can obviously reduce coriamyrtin convulsion incidence rate, prolong its generative latent period, reduce frequency of attack and shorten the time and process of attack, and has the actions of stopping pain and resisting inflammation, and has a certain action of relieving vasoconstriction and raising oxygen consumption of heart muscle, and its biological utilization rate can be raised by 10-59%.

Compositions and systems for topical ophthalmic application, which include an aqueous mixture of steroidal and non-steroidal anti-inflammatory agents in a flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye.

The invention provides a traditional Chinese medicine composition for treating colpitis mycotica, wherein the oral medicines are: 10-20 parts of viscum album, 10-20 parts of angelica, 10-20 of bighead atractylodes rhizome, 10-20 parts of motherwort, 10-20 of astragalus root, 10-20 parts of fructus zizyphi sativae, 10-20 parts of semen cuscutae, 10-20 parts of fruit of glossy privet, 10-20 of mulberry, 10-20 parts of rhizoma anemarrhenae, 10-20 of fructus rubi, 10-20 parts of Chinese magnoliavine fruit, 10-20 parts of scutellaria baicalensis, and 10-20 parts of patrinia; the external medicines are: 10-30 parts of root of Chinese pulsatilla, 10-30 parts of golden cypress, 10-30 parts of radix sophorae flavescentis, 10-30 parts of fructus cnidii, 10-30 parts of cortex dictamni, 10-30 parts of folium artemisiae argyi, 10-30 parts of clove, 10-30 parts of Chinese prickly ash, 10-30 parts of smoked plum, 10-30 parts of rhizoma smilacis glabrae, 10-30 parts of borneol, 10-30 parts of herba, and 10-30 parts of mint. The composition has fast effects of relieving itching, killing insect and degerming, strongly diminishes inflammation antibiotic property, and is high in bacteriostasis ratio, convenient for administration, easy for manufacturing and low in cost.

The invention provides a high-energy enteral nutrition multi polymerizer. The total energy of every 100g of the multi polymerizer is 450-500kJ. The energy ratio is as follows: 16-20% of protein, 35-50% of fat and 40-50% of carbohydrate. The multi polymerizer has the advantages of high fat, high energy, low carbohydrate and rich nutrition, meets the nutritional treatment guideline of modern medicine relevant to malignant tumor, has the obvious anti-tumor effect, and can improve the nutrition condition of tumor patients.

The invention relates to a dermatological pharmaceutical composition for the treatment of skin inflammation diseases, such as dermatitis, atopic dermatitis, vitiligo, alopecia areata, acne, psoriasis and pruritus. The invention comprises a base anti-inflammatory agent, such as indometacin; one or more optional active ingredients selected alternatively from among at least a corticoid and an antibiotic; and a combination of topical antioxidants used to potentiate the anti-inflammatory effect, selected from among green tea, lipoic acid, curcumin, ascorbyl palmitate, Coenzyme Q10, resveratrol, Pycnogenol™, L-camosine, taurine, vitamin E, vitamin C, papaya extract, isoflavones, manganese, lycopene and quercetin. At least one of the topical antioxidants is a peroxisome proliferator-activated receptor-gamma (PPAR-γ) activator. The invention also includes at least one antioxidant substance with an antiproliferative effect on keratonocytes, e.g. manganese, and at least one substance that blocks tumour necrosis factor-alpha (TNF-α) or other cytokines that provoke the acute phase of the inflammatory reaction, also with an antiproliferative effect, e.g. pentoxifylline.

The invention relates to a pharmaceutical composition with liver-protecting effects. The composition comprises the following substances by weight: 6-15 parts of black tea polyphenol and 2-6 parts of a Silybum marianum extract. The silymarin and black tea polyphenol with different drug effects have very clear roles in prevention and treatment of chemical liver injury from different targets and the ways of, and are complementary with each other to effectively prevent and treat chemical liver injury. The two medicines are combined to perform the efficacies of strengthening and nourishing the liver, coursing the liver, detoxifying and immunoloregulation. Tests have proved that the pharmaceutical composition provided by the invention can prevent liver injury.

The present invention discloses clerodendranthus spiatus extract for treating urinary calculus and its preparation process, and belongs to the field of Chinese herbal medicine extract and application technology. The clerodendranthus spiatus extract preparing process includes the following steps: soaking clerodendranthus spiatus in 4-10 times methanol to extract and concentrating to obtain extractum; dissolving the extractum in solvent in the same volume; extracting the solution first with petroleum ether and then with ethyl acetate and concentrating to obtain coarse extract; and chromatographic separation, eluting, collecting and concentrating to operate clerodendranthus spiatus extract A. The clerodendranthus spiatus extract A is liposoluble flavone glycoside compound and has obvious urinary calculus treating effects.

The invention relates to a dexamethasone-RGD polypeptide conjugate shown as general formula i, a preparation method thereof and application. In the formula i, RGDX is tetrapeptide Arg-Gly-Asp-X, wherein X is any amino acid of Val, Phe and Ser. Proved by experiments, the compound of the present invention has excellent immunosuppressive effect and anti-inflammatory effect, and the side effects of osteoporosis is reduced. The conjugate can be used as an immunosuppressant and anti-inflammatory agent for the side effect of low osteoporosis clinically. At the same time, the dexamethasone-RGD polypeptide conjugate of the present invention can self-assemble into stable nanoparticles with particle size of 200-500 nm, therefore the conjugate can be prepared into a target drug of immunosuppressive pharmacosome, microemulsion or liposome.

The invention discloses a preparation method and an application of a ginkgo leaf extract, wherein the method comprises the following steps of: a) washing and then drying ginkgo leaves; b) crashing and sieving; c) soaking by ethanol; d) oscillating by a ultrasonic cell crasher; e) extracting and filtering; and f) condensing in vacuum and drying. The invention has the advantages of adopting an ultrasonic-assisted extraction method, utilizing the functions of strong vibration, extremely high acceleration, strong cultivation effect, even stirring and the like generated by ultrasonic waves, accelerating the entry of the medicament effective constituents into the solvent, simultaneously avoiding the effect of high temperature on extraction constituents and greatly improving the yield of the extract. In the extract, flavonoids accounts for 36 percent, ginkgo terpene lactones account for over 8 percent while the injurant phenolic acid is less than 3PPM, therefore, the product has high safety. The obtained Ginkgo leaf extract of 4 to 6g is added to each kilogram of feeding stuff, therefore, the animal immune anti-inflammatory action and the production property can be raised by more than 10 percent and 2 to 3 percent respectively.

The present invention provides novel mechanisms that regulate the production of anti-inflammatory and pro-inflammatory mediators generated by 5-lipoxygenase. In this regard, the present invention establishes that phosphorylation of 5-Lipoxygenase by protein kinase A, has a crucial role in determining the end products of 5-Lipoxygenase. With translocation to the nucleus, potent proinflammatory leukotrienes are produced, whereas following phosphorylation by protein kinase A, anti-inflammatory mediators are produced. The present invention also discloses compounds that regulate these pro- and anti-inflammatory mediators.

The invention discloses a medicament for treating dermatophytosis, especially applicable to the people who suffer from the dermatophytosis and work outside all day without a rest. The medicament for treating the dermatophytosis can remove the dermatophytosis fundamentally, detoxify and relieve the itching without side-effect. The components for preparing the compound medicament for treating dermatophytosis in percentage are: 40-60% of vitamin B, A 40-60% of vitamin, 10-30% of lightyellow sophora root, 10-30% of chinaberry bark, 6-20% of herba schizonepetae, 20-40% of rhizoma coptidis, 10-30% of Baikal skullcap root, 10-30% of amur corktree bark, 10-30% of artemisia capillaris, 40-80% of dried alum, 12-14% of borneol, 6-10% of sandalwood, 6-15% of curcuma zedoary, 26-70% of gypsum fibrosum, 20%-40% of cnidium monnieri, 1-3% of poria cocos, 1-3% of broom cypress fruit, 1-3% of periostracum cicada, 1-3% of cortex dictamni, 1-3% of flax kernel, 1-3% of amur corktree bark, 1-3% of angelica root, 1-3% of Sichuan pepper, 2-4% of dried alum, 2-4% of lithospermum, 0.5-3.5% of centipede, 5-15% of radix achyranthis bidentatae, 1-5% of root of stephaniatetrandraS.Moore, and 1-5% of akebia stem.

The present invention relates to a pharmaceutical formulation for use in the administration of 2(1H)-quinolinone derivatives long-acting β2-agonists by inhalation. In particular this invention relates to a chemically stable highly efficient TA 2005 HFA solution formulation to be administered by pressurised metered dose inhalers (pMDIs) characterized by a deep lung penetration. The invention also relates to methods for the preparation of said formulation and to its use in respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).

The invention relates to special complete formula feed for sows in the perinatal period. The feed comprises components including corn, fermented soybean meal, fermented peanut meal, oat, super steamed fish meal, egg powder, glucose, brown sugar, an emulsified fish oil-lard compound, seaweed meal, multivitamins, composite organic trace elements, a compound enzyme for pigs, choline chloride, lysine, ethoxyquinoline, phytase, salt, stone powder, calcium hydrophosphate, chitosan oligosaccharide, linseed meal, a cucubalus root-ricepaperplant pith-motherwort herb extract and mushroom powder. The feed effectively solves several common problems such as constipation, prolonged labor, postpartum lactation disorder and inadequate milk in the perinatal period of the sows, provides great help for pig farms for increase of the sow health level, the subsequent litter size and the utilization years as well as reduction of the labor intensity of workers for nursing of the sows in the perinatal period, and has very high economic significance and usage value.

The invention relates to a special compound feed for litopenaeus vannamei. The feed is composed of following components in percentage by weight: 18 to 24% of steam fish meal, 17 to 22% of soybean meal, 15 to 24% of peanut meal, 2 to 4% of spray-dried animal blood cells, 2 to 4% of squid paste, 2 to5% of yeast extract, 20 to 25% of flour, 2 to 3% of fish oil, 1 to 2% of soybean oil, 1.0% of shrimp multi-vitamin, 2.0% of shrimp multi-mineral and 1.0% of litopenaeus vannamei special feed addictive, and the sum of the components mentioned above is 100%. The nutrition composite of the compound feed is obtained from numerous tests according to the nutrition need of litopenaeus vannamei, can fully satisfy the nutrition need of litopenaeus vannamei, improves the immunity and disease preventing ability of litopenaeus vannamei, and promotes the healthy growth of litopenaeus vannamei.

Compositions comprising an effective amount of a curcuminoid species and an effective amount of a diterpene lactone species, a triterpene species or derivatives thereof that have a synergistic effect on specific inhibition of inducible COX-2 activity and have minimal effect on COX-1 activity are disclosed. Methods of using the compositions for providing synergistic anti-inflammatory effects are also disclosed.

The invention relates to the technical field of medicine application, and particularly relates to a liquid medicine for preventing and treating allergic rhinitis and wet tissue or tissue prepared by applying the liquid medicine. The liquid medicine is prepared from the following raw materials in parts by weight: 10-90 parts of magnolia flower, 5-40 parts of centipeda minima and 5-40 parts of cocklebur fruit. The wet tissue and tissue for preventing and treating allergic rhinitis by applying the liquid medicine are prepared from natural skin-friendly non-irritative materials, comprise a plurality of traditional Chinese medicinal effective components with the effects of resisting rhinitis and restoring nasal cavity, and are used for preventing and relieving discomfort of the nose of a patient with allergic rhinitis in daily life and non-invasively cleaning snot and other excretions when rhinitis attacks. Traditional Chinese medicine is developed to the tissue mode which is concise and convenient, the tissue has good application value and market prospect, is advantageous to popularize modern application of traditional Chinese medicines, and is beneficial to pain relieving of patients with allergic rhinitis.

The present invention provides a vibroacoustic sound therapeutic system including an acoustic energy source having means for generating an acoustic drive signal, the acoustic drive signal being characterized by a frequency sweep between a relatively low frequency and a relatively high frequency, and one or more acoustic transducers adapted for operation in a liquid medium, the transducers being responsive to the acoustic drive signal to generate acoustic energy at frequencies corresponding to frequencies of the acoustic drive signal.

The invention provides methods for treating pathological conditions associated with an undesirable inflammatory component. The invention is generally directed to reducing inflammation by administering cells that have one or more of the following effects in an injured subject: interact with splenocytes, preserve splenic mass, increase proliferation of CD4+ and CD8+ T-cells, increase IL-4 and IL-10, decrease IL-6 and IL-1β, and increase M2:M1 macrophage ratio at the site of injury. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to have these effects. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired potency for achieving these effects.

The invention discloses a medical anti-adhesion membrane material with controllable degradation and a preparation method thereof, belonging to the field of biomedical materials. According to the invention, the membrane material is prepared by blending sodium hyaluronate and konjac klucomannan, using lactic acid as a property-modifying additive and using a mixed solution of ammonia water and anhydrous ethanol as a cross-linking agent; sodium hyaluronate is a good anti-adhesion material, but individually used sodium hyaluronate has a fast degradation speed and can not fulfill a good anti-adhesion effect; konjac klucomannan can control the degree of cross-linking, thereby realizing the goal of controllable degradation, and blending of sodium hyaluronate and konjac klucomannan enables sodium hyaluronate to be released slowly, thereby allowing the membrane material to meet demands for anti-adhesion action at different parts. The membrane material has the advantages of nontoxic degradation products, good biocompatibility, hygroscopicity and tensile properties, and the like, and can be used for intervertebral adhesion, intestinal adhesion, skin adhesion, intrauterine adhesion, etc.

An application of proanthocyanidin in preparing the medicines for treating ulcerative colitis and non-bacteria chronic colitis is disclosed.

The invention discloses a red kiwifruit room temperature storage and preservation operating method which comprises the following four steps: picking fresh red kiwifruits, preparing a preservative, dipping the fresh fruits and preserving the fresh fruits. The problems that the fresh red kiwifruits are difficult in room temperature storage and difficult in preservation are solved by utilizing a natural preservation method. According to the preservation operating method disclosed by the invention, due to two times of preservative liquid dipping treatment, dual-layer protection of a high-activity probiotics layer and a moisturizing and preservation antibacterial film is realized, skin shrinkage and fruit rot of the red kiwifruits are obviously controlled, the room temperature storage period and shelf life of the red kiwifruits are effectively prolonged, and the commodity value and economic benefits are improved; and moreover, the method can be popularized to be used in other fresh fruits.

The invention provides an external traditional Chinese medicine liniment for treating acne dermatosis and a preparation method thereof. Raw materials comprises, by weight, 10-15 parts of kuh-seng, 10-15 parts of the root of red-rooted salvia, 5-10 parts of scutellaria baicalensis, 5-10 parts of hemsleya amabilis, 2-5 parts of aloe, 2-5 parts of liquorice and 1-2 parts of borneol. The medicament can be used for controlling acne of various types, has accurate curative effect according to clinical verification, an effect rate of 67.56% and a total efficiency of 97.66%. The medicament also has effects of removing fat, caring skin, mitigating chromatosis and preventing acne. Based on an existing traditional Chinese medicine extraction technology, the invention improves a traditional technology; traditional Chinese medicine pharmacological composition is employed in the formula to overcome large compound of a traditional Chinese medicine, reduce medicine and save cost, etc. A water extraction and alcohol precipitation method and an alcohol extraction and water precipitation method are improved in the traditional Chinese medicine extraction technology, so as to prepare an effective ingredient which is suitable for water alcoholic solution comprehensive extraction. Traditional ethanol concentrations of tincture and spirit are improved in the preparation, and a dosage form has dual stability without adding any antiseptic. Medicament stability and drug effect are enhanced.

An exterior-applied Chinese medicine for treating burn and local phyma and inflammation is prepared from 10 Chinese-medicinal materials including sanguisorba root, catechu, coptis root, myrrh, etc. Its advantages are high curative effect and no by-effect.