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1124results about How to "Good anti-inflammatory effect" patented technology

Phosphodiesterase-4 inhibitor

The invention belongs to the technical field of medicines and particularly relates to a phosphodiesterase-4 inhibitor as shown in a general formula (I) and a pharmaceutically acceptable salt, a stereoisomer or a solvent compound thereof. In the formula, R1, R2, R3, R4, R5, R6, R7, R8, R9, R7', R8', R9', L and a ring A are as defined in the specification. The invention further relates to a preparation method for the compound, a pharmaceutical composition with the compound, and an application of the compound and the pharmaceutical composition to preparation of drugs for treating and / or preventing inflammatory diseases, disease symptoms and disease conditions characterized by or related with undesired inflammatory immune reaction and all diseases induced by or related with TNF-alpha (tumor necrosis factor-alpha) and PDE-4 (phosphodiesterase-4) hypersecretion.
Owner:SHANDONG XUANZHU PHARMA TECH CO LTD

Helicid soft capsule and its preparation method

InactiveCN1535690ALessen the severity of seizuresAlpha-wave exponential decreaseOrganic active ingredientsNervous disorderConvulsionSedative Effects
The present invention provides a helical soft capsule. Every capsule contains 5-200mg of helical, the rest is solvent matrix, the described solvent matrix is one of PEG 300-1000, propylene alcohol, soybean oil and peanut oil or their composition. According to the requirements the medicinal color matter and flavor agent can be added into its liquid medicine. Said invented soft capsule has the sedation, can obviously reduce coriamyrtin convulsion incidence rate, prolong its generative latent period, reduce frequency of attack and shorten the time and process of attack, and has the actions of stopping pain and resisting inflammation, and has a certain action of relieving vasoconstriction and raising oxygen consumption of heart muscle, and its biological utilization rate can be raised by 10-59%.
Owner:KUNMING ZIJIAN BIOTECH

Traditional Chinese medicine composition for treating colpitis mycotica and preparation method of traditional Chinese medicine composition

The invention provides a traditional Chinese medicine composition for treating colpitis mycotica, wherein the oral medicines are: 10-20 parts of viscum album, 10-20 parts of angelica, 10-20 of bighead atractylodes rhizome, 10-20 parts of motherwort, 10-20 of astragalus root, 10-20 parts of fructus zizyphi sativae, 10-20 parts of semen cuscutae, 10-20 parts of fruit of glossy privet, 10-20 of mulberry, 10-20 parts of rhizoma anemarrhenae, 10-20 of fructus rubi, 10-20 parts of Chinese magnoliavine fruit, 10-20 parts of scutellaria baicalensis, and 10-20 parts of patrinia; the external medicines are: 10-30 parts of root of Chinese pulsatilla, 10-30 parts of golden cypress, 10-30 parts of radix sophorae flavescentis, 10-30 parts of fructus cnidii, 10-30 parts of cortex dictamni, 10-30 parts of folium artemisiae argyi, 10-30 parts of clove, 10-30 parts of Chinese prickly ash, 10-30 parts of smoked plum, 10-30 parts of rhizoma smilacis glabrae, 10-30 parts of borneol, 10-30 parts of herba, and 10-30 parts of mint. The composition has fast effects of relieving itching, killing insect and degerming, strongly diminishes inflammation antibiotic property, and is high in bacteriostasis ratio, convenient for administration, easy for manufacturing and low in cost.
Owner:南通市星期七旅游开发有限公司

Dermatological pharmaceutical composition for the treatment of skin inflammation diseases, such as dermatitis, atopic dermatitis, vitiligo, alopecia areata, acne, psoriasis, pruritus or combinations of same

The invention relates to a dermatological pharmaceutical composition for the treatment of skin inflammation diseases, such as dermatitis, atopic dermatitis, vitiligo, alopecia areata, acne, psoriasis and pruritus. The invention comprises a base anti-inflammatory agent, such as indometacin; one or more optional active ingredients selected alternatively from among at least a corticoid and an antibiotic; and a combination of topical antioxidants used to potentiate the anti-inflammatory effect, selected from among green tea, lipoic acid, curcumin, ascorbyl palmitate, Coenzyme Q10, resveratrol, Pycnogenol™, L-camosine, taurine, vitamin E, vitamin C, papaya extract, isoflavones, manganese, lycopene and quercetin. At least one of the topical antioxidants is a peroxisome proliferator-activated receptor-gamma (PPAR-γ) activator. The invention also includes at least one antioxidant substance with an antiproliferative effect on keratonocytes, e.g. manganese, and at least one substance that blocks tumour necrosis factor-alpha (TNF-α) or other cytokines that provoke the acute phase of the inflammatory reaction, also with an antiproliferative effect, e.g. pentoxifylline.
Owner:UMBERT MILL IGNACIO

Preparation method and use of ginkgo-leaf extract

The invention discloses a preparation method and an application of a ginkgo leaf extract, wherein the method comprises the following steps of: a) washing and then drying ginkgo leaves; b) crashing and sieving; c) soaking by ethanol; d) oscillating by a ultrasonic cell crasher; e) extracting and filtering; and f) condensing in vacuum and drying. The invention has the advantages of adopting an ultrasonic-assisted extraction method, utilizing the functions of strong vibration, extremely high acceleration, strong cultivation effect, even stirring and the like generated by ultrasonic waves, accelerating the entry of the medicament effective constituents into the solvent, simultaneously avoiding the effect of high temperature on extraction constituents and greatly improving the yield of the extract. In the extract, flavonoids accounts for 36 percent, ginkgo terpene lactones account for over 8 percent while the injurant phenolic acid is less than 3PPM, therefore, the product has high safety. The obtained Ginkgo leaf extract of 4 to 6g is added to each kilogram of feeding stuff, therefore, the animal immune anti-inflammatory action and the production property can be raised by more than 10 percent and 2 to 3 percent respectively.
Owner:曹阳春

Phosphorylation of 5-lipoxygenase at ser523 and uses thereof

The present invention provides novel mechanisms that regulate the production of anti-inflammatory and pro-inflammatory mediators generated by 5-lipoxygenase. In this regard, the present invention establishes that phosphorylation of 5-Lipoxygenase by protein kinase A, has a crucial role in determining the end products of 5-Lipoxygenase. With translocation to the nucleus, potent proinflammatory leukotrienes are produced, whereas following phosphorylation by protein kinase A, anti-inflammatory mediators are produced. The present invention also discloses compounds that regulate these pro- and anti-inflammatory mediators.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2

Compositions comprising an effective amount of a curcuminoid species and an effective amount of a diterpene lactone species, a triterpene species or derivatives thereof that have a synergistic effect on specific inhibition of inducible COX-2 activity and have minimal effect on COX-1 activity are disclosed. Methods of using the compositions for providing synergistic anti-inflammatory effects are also disclosed.
Owner:METAPROTEOMICS

Liquid medicine for preventing and treating allergic rhinitis and wet tissue or tissue prepared by applying liquid medicine

The invention relates to the technical field of medicine application, and particularly relates to a liquid medicine for preventing and treating allergic rhinitis and wet tissue or tissue prepared by applying the liquid medicine. The liquid medicine is prepared from the following raw materials in parts by weight: 10-90 parts of magnolia flower, 5-40 parts of centipeda minima and 5-40 parts of cocklebur fruit. The wet tissue and tissue for preventing and treating allergic rhinitis by applying the liquid medicine are prepared from natural skin-friendly non-irritative materials, comprise a plurality of traditional Chinese medicinal effective components with the effects of resisting rhinitis and restoring nasal cavity, and are used for preventing and relieving discomfort of the nose of a patient with allergic rhinitis in daily life and non-invasively cleaning snot and other excretions when rhinitis attacks. Traditional Chinese medicine is developed to the tissue mode which is concise and convenient, the tissue has good application value and market prospect, is advantageous to popularize modern application of traditional Chinese medicines, and is beneficial to pain relieving of patients with allergic rhinitis.
Owner:张大威 +1

External traditional Chinese medicine liniment for treating acne dermatosis and preparation method thereof

The invention provides an external traditional Chinese medicine liniment for treating acne dermatosis and a preparation method thereof. Raw materials comprises, by weight, 10-15 parts of kuh-seng, 10-15 parts of the root of red-rooted salvia, 5-10 parts of scutellaria baicalensis, 5-10 parts of hemsleya amabilis, 2-5 parts of aloe, 2-5 parts of liquorice and 1-2 parts of borneol. The medicament can be used for controlling acne of various types, has accurate curative effect according to clinical verification, an effect rate of 67.56% and a total efficiency of 97.66%. The medicament also has effects of removing fat, caring skin, mitigating chromatosis and preventing acne. Based on an existing traditional Chinese medicine extraction technology, the invention improves a traditional technology; traditional Chinese medicine pharmacological composition is employed in the formula to overcome large compound of a traditional Chinese medicine, reduce medicine and save cost, etc. A water extraction and alcohol precipitation method and an alcohol extraction and water precipitation method are improved in the traditional Chinese medicine extraction technology, so as to prepare an effective ingredient which is suitable for water alcoholic solution comprehensive extraction. Traditional ethanol concentrations of tincture and spirit are improved in the preparation, and a dosage form has dual stability without adding any antiseptic. Medicament stability and drug effect are enhanced.
Owner:CHENGDU YIHE BANGSEN TECH
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