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1287 results about "Proanthocyanidin" patented technology
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Proanthocyanidins are a class of polyphenols found in a variety of plants. Chemically, they are oligomeric flavonoids. Many are oligomers of catechin and epicatechin and their gallic acid esters. More complex polyphenols, having the same polymeric building block, form the group of tannins.
Metabolic capacity enhancing compositions and methods for use in a mammal
InactiveUS20060024385A1Increase vitalityImproved and increased energy processing of given caloric foods)BiocideOrganic active ingredientsLipid formationMammal
Metabolic energy capacity enhancing compositions and methods for reducing oxidative stress and improving vitality in a mammal are disclosed. A composition for increasing metabolic energy capacity may be in a palatable liquid formulation or a solid dosage form and typically includes an anti-oxidant containing phytonectar and an energy catalyst. An anti-oxidant may include a polyphenol, anthrocyanin, bioflavonoid, proanthocyanidin, and a xanthone. An energy catalyst may include a mineral, vitamin, co-vitamin, carbohydrate and a lipid. In a presently preferred embodiment a composition includes phytonectar extracts from grape, aloe vera, apple, morinda citrifolia, scullcap, blueberry, prune, cranberry, elderberry, bilberry, and gentain and a mineral blend containing calcium, magnesium, manganese, zinc, chromium, selenium, iron, copper, molybdenum, vanadium, potassium, iodine, and cobalt. A method for increasing metabolic energy capacity in a mammal may include consuming a chemical component having the ability to undergo oxidation, producing free radicals and administering a composition having an anti-oxidant containing phytonectar and an energy catalyst.
Owner:PEDERSEN MARK A
Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions
Disclosed and claimed are cocoa extracts, compounds, combinations thereof and compositions containing the same, such as polyphenols or procyanidins, methods for preparing such extracts, compounds and compositions, as well as uses for them, especially a polymeric compound of the formula An, wherein A is a monomer of the formula:wherein n is an integer from 2 to 18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units;R is 3-(alpha)-OH, 3-(beta)-OH, 3-(alpha)-O-sugar, or 3-(beta)-O-sugar;bonding between adjacent monomers takes place at positions 4, 6 or 8;a bond of an additional monomeric unit in position 4 has alpha or beta stereochemistry;X, Y and Z are selected from the group consisting of monomeric unit A, hydrogen, and a sugar, with the provisos that as to the at least one terminal monomeric unit, bonding of the additional monomeric unit thereto (the bonding of the additional monomeric unit adjacent to the terminal monomeric unit) is at position 4 and optionally Y=Z=hydrogen;the sugar is optionally substituted with a phenolic moiety, at any position on the sugar, for instance via an ester bond, andpharmaceutically acceptable salts or derivatives thereof (including oxidation products).
Owner:MARS INC
Method and synergistic composition for treating attention deficit/hyperactivity disorder
InactiveUS6541043B2Minimize side effectsBiocideHydroxy compound active ingredientsBeta-CaroteneBetaine
A composition and method for treating Attention Deficit / Hyperactivity Disorder (ADHD) is provided which can be used both with and without ethical drugs now used to treat ADHD. The composition contains dimethylaminoethanol (DMAE), omega 3-fatty acids, betaine, oligomeric proanthocyanidins (OPC), folic acid, vitamins C, E, B12, B6, B5 and beta-carotene and minerals (calcium, magnesium, zinc and selenium). Ethical drugs such as amphetamines, methylphenidate HCl and pemoline are known to control ADHD, but each has significant side effects when used in their therapeutic dose. When combining the composition with such ethical drugs, the amount of the ethical drug can be lowered below a level which causes undesirable side effects which is an important feature. Preferred compositions contain one or more of lecithin, choline, 5-hydroxytryptophan, tyrosine, Reishi Extract, Kava Extract, Gingko, Ginseng and St. John's Wort.
Owner:PHILIP C LANG
Product and method for oral administration of nutraceuticals
ActiveUS20060134294A1Without detrimentally affecting the glycemic index of the consumerGreat tasteConfectionerySweetmeatsPlant sterolTagatose
A delivery system for nutraceuticals uses a low caloric chocolate base for containing one or more nutraceuticals, either blended with the chocolate itself, or added as a liquid or crème filling. The chocolate has a relatively high level of oligomeric proanthocyanadins, and preferably further includes a phytosterol and DHA, as well as being sweetened with a sweetener blend containing tagatose and a secondary low caloric, high intensity sweetener, preferably Lo Han Guo extract. Using the inventive system, delivery of nutraceuticals in unit dosage form is facilitated, as the selected dose is carried within individual chocolate product pieces that taste substantially the same as conventional chocolate, though with few calories from carbohydrates, or effects on insulin response encountered with typical chocolate formulations.
Owner:EURARK
Composition and method for reducing the risk or progression of cardiovascular, glaucoma, tardive dyskinesia and other diseases
InactiveUS20040087479A1Reduce riskShorten the progressBiocideOrganic active ingredientsBeta-CaroteneAdditive ingredient
Elevated levels of homocysteine have been implicated as an important risk factor for cardiovascular and other diseases. A composition for decreasing levels of plasma homocysteine and a method for administering the composition are provided, the composition containing dextromethorphan (DM), folic acid and vitamins B6 and B12. The composition provides a synergistic therapeutic effect so that lower amounts of the above ingredients may be employed to minimize any undesirable side effects caused by the use of high levels of a component such as DM. Preferred compositions for cardiovascular diseases further include lecithin, vitamin E, betacarotene, procyanidins / flavonoids, trimethylglycine, garlic oil and minerals. Other compositions for treating glaucoma include bilberry, bioflavonoids and beta-carotene and for treating tardive dyskinesia include an antioxidant such a grape seed extract and pine bark extract, lecithin and oligomeric proanthocyanidins. The compositions may be administered using any suitable means such as orally or intravenous.
Owner:SOSNOWSKI ROBERT E +1
Plant enzyme and preparation method thereof
The invention provides a preparation method for plant enzymes. According to the method, a plurality of plants, vegetables and fruits, seeds, herbal medicines, mushrooms and alga are used as raw materials, natural extraction of plant enzymes is carried out to obtain liquid containing plant active components, and a liquid stock solution of plant enzymes is obtained after fermentation and maturation of the liquid containing plant active components; the obtained liquid stock solution of plant enzymes contains a multienzyme ferment, a protein decomposition enzyme, a fat decomposition enzyme, a starch decomposition enzyme, proanthocyanidin, a plurality of natural vitamins, mineral matters, amino acids, trace elements, etc. The obtained liquid stock solution of plant enzymes is prepared into plant enzyme oral liquid, plant enzyme solid powder or plant enzyme capsules. The preparation method provided in the invention has the following advantages: preparation conditions in the method are simulation of natural generation conditions of enzymes, so preparation theory is scientific; preparation equipment is simple, applicable to large scale production; obtained plant enzymes never contain artificial pigments, synthetic fragrances or antiseptics, and are pure natural. The plant enzymes can be extensively used in health products or cosmetic and make-up products.
Owner:JILIN AODONG OHTAKA ENZYME
Tannin-chitosan composites
ActiveUS20110059162A1Improve mechanical propertiesImprove efficiencyAntibacterial agentsOrganic active ingredientsAdjuvantHydrogel film
Owner:WISCONSIN ALUMNI RES FOUND
Enteric formulations of proanthocyanidin polymer antidiarrheal compositions
InactiveUS20050019389A1Reduce secretionReduce acidityAntibacterial agentsBiocideSecretory diarrheaPharmaceutical formulation
Pharmaceutical compositions containing a proanthocyanidin polymer composition which are useful for the treatment and prevention of secretory diarrhea are provided. The invention specifically relates to pharmaceutical formulations of a proanthocyanidin polymer composition which has been isolated from a Croton spp. or a Calophyllum spp. In particular, the invention relates to a formulation of a proanthocyanidin polymer composition which protects the composition from the effects of stomach acid after oral administration, particularly to those formulations which are enteric coated. The invention also relates to methods of producing a directly compressible proanthocyanidin polymer composition, as well as compositions containing the directly compressible proanthocyanidin polymer composition.
Owner:NAPO PHARMA INC
Composition for improving blood cholesterol levels
A nutritional composition for improving blood cholesterol by jointly and simultaneously inhibiting cholesterol absorption, decreasing blood LDL levels, increasing blood HDL levels and interfering with HMG-CoA reductase synthesis or degradation in an individual comprising, therapeutically effective amounts of plant sterols or plant stanols or derivatives thereof, procyanidins, policosanol and niacin or derivatives of niacin is provided. Both a composition and a method are provided by the present disclosure.
Owner:IOMEDIX DEV INT
Tannin-chitosan composites
ActiveUS8642088B2Improve mechanical propertiesImprove efficiencyAntibacterial agentsPowder deliveryAdjuvantHydrogel film
The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and / or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.
Owner:WISCONSIN ALUMNI RES FOUND
Procyanidins oligomer and its preparing method and use
InactiveCN1654463AStrong Antioxidant FunctionStrong antibacterial functionOrganic chemistryAnimal feeding stuffAntioxidantFeed additive
The present invention relates to one kind of protocyanidin oligomer and its production process and application in food, health article, feed additive and animal medicine. The protocyanidin oligomer is dimer, trimer and tetramer, and is produced with condensated tannin as material and through oxidizing degradation with hydrogen peroxide or potassium chlorate as oxidant to obtain yellow or brown semi-transparent liquid and subsequent separation and purification. The protocyanidin oligomer of the present invention has powerful antioxidant function and antibiotic function, and my be used in food owing to no astringent taste and no negative effect on the activity of amylase in digestive tract, as feed additive to reduce coccidiosis infection of fowls and low cholesterol content in egg.
Owner:浙江德清利欣生物科技有限公司
Extraction agent used for extracting proanthocyanidin from plants and extracting method
An extractant for extracting proanthocyanidin from plant is metaphosphoric acid and / or sulfite. Its extracting process includes adding water to prepare solution, regulating pH value, immersing extracting by controlling temp and time, filtering, purifying, solvent eluting, concentrating and drying. Its advantages are dosage of extractant, high extracting rate and high purity and water solubility of product.
Owner:HUAZHONG AGRI UNIV
Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
A process is disclosed for the production of polyphenol oligomers having n polyphenol monomers, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomers. Advantageously, polyphenol monomers forming the polyphenol oligomers may be the same or different.
Owner:MARS INC
Use of oligomeric proanthrocyanidins
Methods of treating skin to counteract the effects of ageing as well as conditions such as acne, rosacea and cellulite along with methods of counteracting specific adverse biochemical reactions in the dermal region are disclosed, wherein the methods comprise (a) providing a skin substrate to be treated; and contacting the skin substrate with a cosmetic preparation comprising at least one oligomeric proanthocyanidin.
Owner:COGNIS FRANCE SA
Method of extracting oligo proanthocyanidin of grape seed
The method for extracting grape-seed oligoproanthocyandin includes the following steps: pulverizing grape-seed, sieving and defatting to obtain grape-seed dregs, extracting the grape-seed dregs by using organic solvent containing inorganic mineral acid, feltering, neutralizing with inorganic alkali, filtering and reduced pressure concentrating to obtain proanthocyanidin crude extract, then adding petroelum ether or chlorform into the crude extract, standing still, filtering and drying to obtain refined proanthocyanidin. The utilization of said method can quickly and simple extract the grape-seeds-waste material of winery and can obtain the invented oligoproanthocyanidin whose content is greater than 60% and yield can be up to 2%.
Owner:XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
Cosmetic and/or dermopharmaceutical preparations containing leaf extracts of the plant Argania spinosa
InactiveUS7105184B2Maintain good propertiesGood effectCosmetic preparationsBiocideSterolProanthocyanidin
Owner:COGNIS FRANCE SA
Procyanidin-L-arginine combinations
InactiveUS20030215558A1Enhanced levelReduce bitterDough treatmentConfectioneryButter cocoaProanthocyanidin
Cocoa components having enhanced levels of cocoa polyphenols, processes for producing the cocoa components while conserving a significant amount of the cocoa polyphenols, compositions containing the cocoa components or the cocoa polyphenols, and methods of using the cocoa components or the cocoa polyphenols for improving the health of a mammal are described. The cocoa components include partially and fully defatted cocoa solids, cocoa nibs and fractions derived therefrom, cocoa polyphenol extracts, cocoa butter, chocolate liquors, and mixtures thereof. The invention provides processes for extracting fat from cocoa beans and for otherwise processing cocoa beans to yield a cocoa component having conserved concentrations of polyphenols relative to the starting materials.
Owner:MARS INC
Lycium ruthenicum tablets and production method thereof
InactiveCN103431327ASolve the costSolve the problem that anthocyanins are easily destroyedFood shapingFood preparationBetacyaninsOrganic solvent
The invention relates to lycium ruthenicum tablets and a production method thereof. The lycium ruthenicum tablets are prepared by taking lycium ruthenicum as a raw material, selecting, washing, extracting, centrifuging for separation, performing membrane concentration, performing vacuum concentration, weighing, drying, grinding, mixing, pelletizing, drying, straightening and tabletting. The purpose of the invention is to solve the problems of high procyanidine loss and high organic solvent residue content when the lycium ruthenicum tablets are produced by a traditional method. The production method is simple and low in cost, the extraction rate of procyanidine reaches more than 92%, and the prepared lycium ruthenicum tablets are convenient to carry, high in added value and free from organic solvent residues.
Owner:GEERMU YUANXINTANG BIOLOGICAL SCI & TECH
Enteric formulations of proanthocyanidin polymer antidiarrheal compositions
InactiveUS7323195B2Improve compression performanceReduce weightAntibacterial agentsBiocideSecretory diarrheaPharmaceutical formulation
Pharmaceutical compositions containing a proanthocyanidin polymer composition which are useful for the treatment and prevention of secretory diarrhea are provided. The invention specifically relates to pharmaceutical formulations of a proanthocyanidin polymer composition which has been isolated from a Croton spp. or a Calophyllum spp. In particular, the invention relates to a formulation of a proanthocyanidin polymer composition which protects the composition from the effects of stomach acid after oral administration, particularly to those formulations which are enteric coated. The invention also relates to methods of producing a directly compressible proanthocyanidin polymer composition, as well as compositions containing the directly compressible proanthocyanidin polymer composition.
Owner:NAPO PHARMA INC
Method for extracting oligomeric proanthocyanidins
InactiveCN101845035AHigh purityHigh yieldOrganic chemistryOther chemical processesGradient elutionSolvent
The invention discloses a method for extracting oligomeric proanthocyanidins, which comprises the following steps of: extracting a plant raw material containing the oligomeric proanthocyanidins with a solvent; enabling a crude extract to pass through a macroporous adsorbent resin column; eluting with water to remove protein and polysaccharide impurities; carrying out gradient elution with water and one or more selecting from alcohol, methyl alcohol and acetone as an eluant; collecting mixed solution with the volume ratio of n-butyl alcohol, acetic acid and water of 4:1:5; standing for demixing, wherein the solution at upper layer is a developing solvent; and carrying out silica gel thin-layer chromatography, wherein the elution part with the Rf value of 0.2-0.5 on a thin-layer chromatography plate is the oligomeric proanthocyanidins extract. Compared with the prior art, the invention has the advantages that the purity and the yield are both remarkably improved, the yield of the oligomeric proanthocyanidins can reach more than 80 percent, the product purity is no less than 50 percent and is basically more than 80 percent, and the method has simple and convenient process, low cost and easy industrialization.
Owner:SHANGHAI INST OF PHARMA IND
Method of preparing oligomeric proanthocyanidins
InactiveCN101012216AImproves antioxidant activityIncrease productionOrganic chemistryOligomerProanthocyanidin
The invention discloses a making method to crack C-C bond among protocyanin polymer into oligomer protocyanin, which comprises the following steps: dissolving polymer in the solvent; adding 1-10mg / ml degrading liquid in the polymer; adding 5-20% acid catalyst in the degrading liquid; swaying evenly; reacting under 40-90 deg.c for 0.5-2h; insulating air.
Owner:ZHEJIANG UNIV
Anti-oxidation health-care wine and its production method
The invention relates to an anti-oxidation health-care wine and its production method, wherein the wine is prepared from the oxidation resistant reactive constituents in grape seed and peel extracted with high grade white spirit or brandy with high ethanol content, the the oxidation resistant reactive constituents in grape seed and peel is proanthocyanidin, resveratrol, polydatin, which can effectively remove excess oxygen-derived free radicals in human bodies.
Owner:RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
Reducing appetite in mammals by administering procyanidin and hydroxycitric acid
Procyanidin, optionally combined with hydroxycitric acid, is used in a method for the reduction of appetite in a mammal. Preferably procyanidin is administered to the mammal in a dosage of between 0.5 and 100 mg per kg bodyweight. Also shown is a process for the manufacture of an appetite reducing composition.
Owner:GNC HLDG LLC
Method for treatment of constipation-predominant irritable bowel syndrome
ActiveUS7556831B2Effective treatmentIncrease the number ofBiocideDigestive systemProanthocyanidinConstipation predominant irritable bowel syndrome
Methods for treating constipation-predominant irritable bowel syndrome comprise administering to a patient in need thereof a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat constipation-predominant irritable bowel syndrome (c-IBS). Treatment of c-IBS includes the treatment of the constipation component of c-IBS as well as the pain and abdominal discomfort associated with c-IBS. In one embodiment, the polymeric proanthocyanidin compound is crofelemer. In addition, methods for treating alternating constipation-predominant / diarrhea-predominant irritable bowel syndrome are an alternative embodiment of the invention.
Owner:NAPO PHARMA INC
Method of preparing blueberry leaf tea beverage
InactiveCN101129152APrevent rustPrevent bacterial growthTea substituesFood preparationNervous systemProanthocyanidin
The invention relates to a blueberry leaves drink with health function based on the blueberry leaves as main material and its making method, wherein the blueberry leaves contents a great amount of flavonoid with more than 40 physiologically activities of reducing blood sugar and blood fat and resisting arrhythmia, the resisting free radical oxidation ability of the blueberry is not compared with the other anti-oxidizing agent, meanwhile there is great amount proanthocyanidins contented in the blueberry with very good health function to the nervous system for children especially for the pregnant woman conspicuously. The making method is characterized by the following: picking the blueberry leaves with more than 90 days growth; using the technique process of washing, immersing, quick freezing, disintegrating, chilling, extracting with vacuum low-temperature, freezing, filtering, allocating, flash sterilizing and germ-free canned. The invention guarantees not to damage the nutrition and effective and active substances in the material almost, which makes the product have certain health function.
Owner:LIAONING TODAY AGRI
Lycium ruthenicum Murr effective extract and its extraction method and use
InactiveCN103230473ALess impuritiesHigh purityOrganic active ingredientsOrganic chemistryWater bathsDistillation
The invention discloses Lycium ruthenicum Murr effective extract and its extraction method and use. The extraction method comprises the following steps of carrying out vacuum drying of Lycium ruthenicum Murr, crushing it, adding 95% of ethanol into the crushed Lycium ruthenicum Murr, carrying out backflow 2 times, wherein each backflow process lasts for 1h, carrying out filtration, carrying out distillation of the filtrate at a temperature of 75 DEG C for concentration, transferring the concentrate into an evaporating dish, carrying out water-bath evaporation, carrying out vacuum drying at a temperature of 70 DEG C for 2h to obtain dry extract, adding methanol into the dry extract until a constant volume is realized, filtering by an organic microporous filter membrane having the aperture size of 0.45 microns and carrying out procyanidine extraction. The Lycium ruthenicum Murr effective extract obtained by the scientific and reasonable extraction method has novel purposes of reducing blood pressure, blood fat and blood sugar. The extraction method provides a novel measure for effective and full utilization of the Lycium ruthenicum Murr effective extract in products for treating or preventing diabetes, hyperlipidemia and hypertension. The extraction method shortens extraction separation time, reduces energy consumption in processes, and effectively reduces a production cost. The Lycium ruthenicum Murr effective extract has high purity, stable performances, fewer extract impurities and good quality. The extraction method adopts pharmaceutical health-care products having antioxidation effects.
Owner:SHANGHAI GENE CELL BIO MEDICAL TECH
Plant enzyme and preparation method thereof
Owner:JILIN AODONG OHTAKA ENZYME
Method for extracting oil and procyanidin from grape seeds
InactiveCN102517144AReduce dosageLow extraction temperatureOrganic chemistryAntinoxious agentsBetacyaninsNatural product
The invention relates to a technology for extracting effective components from a natural product and in particular relates to a method for extracting oil and procyanidin from grape seeds. The method comprises the following process steps: preparing grape seeds, grinding, performing ultrasonic extraction to obtain grape seed oil, and performing ultrasonic extraction to obtain procyanidin. The method integrates the characteristics of an ultrasonic extraction method and a double-solvent extraction method, has the characteristics of low solvent dosage, low extraction cost, high extraction efficiency, less influence on the environment and the like, and can be used for effectively avoiding the problem that in the extraction process of the prior art, the bioactivities of grape seed oil and procyanidin are damaged.
Owner:NINGXIA UNIVERSITY
Synthetic methods for preparing procyanidin oligomers
Processes are disclosed for the production of linear and branched procyanidin oligomers having “n” procyanidin monomeric units where n is 2 to 18. The processes include coupling protected, activated monomers with an unprotected monomer to produce a partially protected (4→8) dimer. The dimer is optionally blocked, coupled with an activated protected monomer to produce a partially protected, optionally blocked trimer, and deprotected. The steps can be repeated to produce higher oligomers. Processes are also provided for producing (8→8), (8→6), and (6→6) dimers and doubly branched oligomers. Crystalline 8-bromo tetra-O-benzyl (−)-epicatechin is produced under certain conditions.
Owner:MARS INC
Formulations for the treatment of arthritis conditions
InactiveUS20060280811A1Reduce cell proliferationStimulate proteoglycan synthesisBiocideNervous disorderBeta-boswellic acidGluconic acid
The present invention relates to formulations comprising combinations of analgesic / anti-inflammatory, immunomodulating and cartilage-reconstructing agents in particular comprising saligenig, boswellic acid, procyanidins, N-acety-glucosamine and either glucoronic acid or glucoronolactone, for the treatment of rheumatoid arthritis and, more generally, of arthritis conditions.
Owner:INDENA SPA
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