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Lycium ruthenicum Murr effective extract and its extraction method and use

An extraction method and extract technology, which are applied in the field of black wolfberry effective extract, extraction and extract application, can solve the problems of lack of extraction technology of black wolfberry, and achieve shortening of extraction and separation time, reduction of energy consumption, and stable performance Effect

Inactive Publication Date: 2013-08-07
SHANGHAI GENE CELL BIO MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0029] It can be seen that the effective matter extraction technology of subdivided black fruit Lycium barbarum suitable for industrial application is still lacking.

Method used

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  • Lycium ruthenicum Murr effective extract and its extraction method and use
  • Lycium ruthenicum Murr effective extract and its extraction method and use
  • Lycium ruthenicum Murr effective extract and its extraction method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Using the dry extract of Lycium ruthenicum or the proanthocyanidins extracted therefrom as the effective substance, the pigment drug of Lycium nigra for the treatment of hyperlipidemia was prepared.

[0039] Using single factor comparison and orthogonal experiment method, the optimal extraction conditions of Lycium barbarum nigra pigment are as follows: 80% ethanol with pH 3.0 is used as extractant, extraction temperature is 50℃, extraction time is 3h, and solid-liquid ratio is 1:1 40; Use X-5 macroporous adsorption resin to purify the pigment. The optimal adsorption conditions are the resin column diameter-height ratio of 1:15, the flow rate of 3mL / min, pH 3.0, and the pigment solution concentration of 1g / L. The volume of wet resin reaches 0.03715g / mL; while 95% 7 alcohol is used as the eluent, the desorption effect is the best under the conditions of pH 2.0, flow rate 5mL / min, and 3 times the volume of the column bed, and the pigment is recovered. The rate ...

Embodiment 2

[0043] Example 2: Use black fruit Lycium barbarum dry extract or the proanthocyanidins extracted therefrom as effective substances to be used for scavenging DPPH free radicals, -OH and -O 2 Both have better treatment of black fruit wolfberry pigment health medicine.

[0044] Ultrasound-microwave synergistic extraction was used to extract the pigment of Lycium nigra, and spectrophotometry was used to detect the scavenging ability of the pigment of Lycium nigra to DPPH free radical, hydroxyl radical-OH and superoxide anion free radical-O2; The pigment solution has a good scavenging effect on DPPH free radicals, -OH and -O2.

[0045] The physicochemical properties and stability of black fruit wolfberry pigment were studied. The results show that black fruit wolfberry pigment is easily soluble in water and belongs to anthocyanin pigments; under acidic conditions, it has a certain tolerance to heat, and is resistant to visible light and ultraviolet light. The performance of light ...

Embodiment 3

[0046] Example 3: Using Lycium nigra fruit as raw material and ethanol as extractant, the influence of single factors such as ethanol concentration, extraction time, solid-liquid ratio, extraction temperature, etc. on the extraction effect of Lycium nigra pigments was discussed: on the basis of single factor experiment In the above, the L16(45) orthogonal test was used to determine the optimal extraction process for the pigment of Lycium ruthenicum. The results showed that the optimal extraction process for the pigment of Lycium ruthenica was 50% ethanol volume fraction, 60min extraction time, and the ratio of solid to liquid 1∶12 , the extraction temperature was 50 °C.

[0047] The anti-oxidative effect of Lycium nigra extract was determined by phenanthroline-Fe2+ oxidation method and pyrogallol auto-oxidation method; The scavenging rate of hydroxyl radical-OH is 60% ethanol > 95% ethanol > acetone > 95% ethanol containing 0.5% hydrochloric acid; the scavenging rate of supero...

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Abstract

The invention discloses Lycium ruthenicum Murr effective extract and its extraction method and use. The extraction method comprises the following steps of carrying out vacuum drying of Lycium ruthenicum Murr, crushing it, adding 95% of ethanol into the crushed Lycium ruthenicum Murr, carrying out backflow 2 times, wherein each backflow process lasts for 1h, carrying out filtration, carrying out distillation of the filtrate at a temperature of 75 DEG C for concentration, transferring the concentrate into an evaporating dish, carrying out water-bath evaporation, carrying out vacuum drying at a temperature of 70 DEG C for 2h to obtain dry extract, adding methanol into the dry extract until a constant volume is realized, filtering by an organic microporous filter membrane having the aperture size of 0.45 microns and carrying out procyanidine extraction. The Lycium ruthenicum Murr effective extract obtained by the scientific and reasonable extraction method has novel purposes of reducing blood pressure, blood fat and blood sugar. The extraction method provides a novel measure for effective and full utilization of the Lycium ruthenicum Murr effective extract in products for treating or preventing diabetes, hyperlipidemia and hypertension. The extraction method shortens extraction separation time, reduces energy consumption in processes, and effectively reduces a production cost. The Lycium ruthenicum Murr effective extract has high purity, stable performances, fewer extract impurities and good quality. The extraction method adopts pharmaceutical health-care products having antioxidation effects.

Description

technical field [0001] The invention relates to the technical field of treatment of international patent classification A61K36 / 815 Lycium barbarum or CO7D heterocyclic compounds, in particular to an effective extract of black Lycium barbarum, an extraction method and the application of the extract. Background technique [0002] In the prior art, Lycium barbarum is an important economic plant and a good product for both medicine and food, belonging to Solanaceae, and Lycium barbarum is a deciduous shrub. There are more than 80 species of this genus, and there are 7 kinds of wolfberry distributed in my country: Ningxia wolfberry, wolfberry, black fruit wolfberry, Xinjiang wolfberry, calyx wolfberry, column tube wolfberry, and Yunnan wolfberry. Among them, there are 3 kinds of traditional medicinal value, namely Huangguo wolfberry or Ningxia wolfberry variety, northern wolfberry or wolfberry variety, red branch wolfberry or Xinjiang wolfberry variety. In addition, the medicina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815C07D311/62A61K31/353A61K31/715A61P3/06A61P3/10A61P39/00
Inventor 黄盼华
Owner SHANGHAI GENE CELL BIO MEDICAL TECH
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