96 results about "Flavone derivatives" patented technology

A cosmetic and / or dermopharmaceutical composition containing an extract selected from the group consisting of flavone derivatives, saponosides, oligomeric procyanolidones, sterols, and mixtures thereof, all of which are derived from an Argania spinosa plant.

The present invention relates to flavone derivatives in the structure as shown, and their preparation process and intermediate. These compounds have excellent PDE5 inhibiting activity, and may be applied in treating sexual disorder and vasoconstriction related diseases.

The invention relates to a fluorescence enhancement type hydrogen sulfide fluorescent probe and particularly relates to a fluorescence enhancement type hydrogen sulfide fluorescent probe based on flavone derivatives. Flavone derivatives are directly reacted with 2,4-dinitrofluorobenzene, and a reaction product is subjected to column chromatography to generate a pure probe product. According to the fluorescence enhancement type hydrogen sulfide fluorescent probe, probe molecules have the maximum absorption wavelengths of 460nm, relatively good solubility in a 1.5mM CTAB water solution and stable optical performance; by adding the probe molecules together with hydrogen sulfide, the absorption wavelengths are blueshifted from 460nm to 450nm, and the intensity of a fluorescence spectrum is continuously enhanced at 612nm and is maximally enhanced by 96 times. According to the fluorescence enhancement type hydrogen sulfide fluorescent probe, the deficiencies that an existing fluorescent probe is slow in response to hydrogen sulfide and high in detection line, and detection wavelengths are in a visible light region are overcome; the probe molecules are high in sensitivity, stable in optical performance, relatively high in synthetic yield, strong in capability of identifying hydrogen sulfide, high in response speed, wide in detection range and low in detection lower limit, the response range is 0-50 mu M, and the detection limit is 0.09 mu M; therefore, the fluorescent probe has practical application values in the fields of biological chemistry, environmental science and the like.

A fluoric isoflavone derivative and its preparing process are disclosed. Said derivative can be used to prepare the medicines for treating cancer, hypertension, hyperglycemia, dysphoria and bacterialand viral diseases. Its advantages are high curative effect and low poison.

Flavone derivatives, preparative method of the derivatives and use thereof as medicaments for treating diabetes. The structure of the derivatives is presented by formula 1: In the structure, R1 and R2, which are identical or not, represent hydrogen atom, halogen, cyano, hydroxyl, trifluoromethyl, thio-methyl, benzyloxy, C1-C8 linear chain or branch chain alkyl, C1-C8 linear chain or branch chain alkoxy. The pharmacological test indicates that the flavone derivatives can significantly increase the glucose consumption of Hep-G2 cell with insulin resistance activity, promote translocation of glucose transporter 4 of skeletal muscle cells (L6GLUT4myc) at different level, and significantly increase glucose intake and utilization by cells. The test proves the fact for the first time that the flavone derivatives can significantly promote translocation of glucose transporter 4 of skeletal muscle cells, and one of the mechanisms for treating diabetes is activating the cell AMPK phosphorylation and phosphorylating the downstream ACC.

The invention discloses a biflavone derivative fluorescent probe, a preparation method thereof and application of the biflavone derivative fluorescent probe in brain glioma imaging. The chemical nameof the biflavone derivative fluorescent probe is 1, 4-phenyl bis (4-oxo-4H-benzopyran-2, 3-diyl) diacrylate (PPDC), and the molecular formula of the biflavone derivative fluorescent probe is C30H22O8.The probe PPDC is obtained through two-step synthesis, shows great Stokes shift (261 nm), and can effectively overcome the defect of biological application blockage caused by fluorescence self-absorption. Fluorescence analysis research shows that the compound can be used for high-sensitivity detection of cysteine with the detection limit being 0.01 mu M; in addition, the probe can be used for effectively distinguishing interferent glutathione and homocysteine of cysteine in an organism. Accurate detection of trace cysteine in brain glial cells is helpful for early diagnosis of brain glioma. In view of the defects of current brain glioma in early detection and accurate excision, the method is expected to realize accurate surgical navigation in clinical surgical excision of the brain glioma, and has a good application prospect.

The invention relates to a method for synthesizing a 3-aryl flavone or coumarin compound through photo-initiation, and applications of the 3-aryl flavone or coumarin compound. The synthesis method comprises the following steps: exciting a flavone substance by visible light under an alkaline condition, and carrying out a monon transfer reaction with an aryl halide to initiate free radicals so as togenerate a 3-aryl flavone derivative in one step. According to the invention, the photoreaction activity of flavone and coumarin compounds under alkaline conditions is utilized, and the 3-aryl flavone or coumarin compound is synthesized through a one-step method by initiating free radicals through a single electron transfer reaction between a photo-excited flavone or coumarin compound and aryl halide, so that the method is simple and efficient, raw materials and reagents are cheap and easy to obtain, the reaction yield is high, few byproducts are produced, and the chemical and regioselectivity of the reaction is high.

The invention discloses a 8-alkylamine propyl-5, 7-disubstituted flavone derivant, which is characterized by the following: adopting flavone with tumour-proof activity as primer; introducing different alkylamine propyls into 8-position of mother core of flavone; synthesizing a series of product with ECA-109, A-549, HL-60, PC-3 and so on to inhibit external breeding.

The present invention provides a 3′,4′,5-trimethoxy flavone derivative and a pharmaceutically acceptable salt thereof, preparation thereof, and a pharmaceutical composition for the treatment and prevention of dry eye syndrome comprising the same as an active ingredient.The 3′,4′,5-trimethoxy flavone derivative and its pharmaceutically acceptable salt inhibit corneal damage through excellent stimulatory action on mucus secretion in the conjunctiva and therefore may be effective as a prophylactic or therapeutic agent for dry eye syndrome.