63 results about "Isoflavone Derivatives" patented technology

Methods for the hydrogenation of isoflavones are described which provide access to workable quantities of isoflavan-4-ols, isoflav-3-enes, and isoflavans. The isoflavone derivatives can be obtained in high purity and in near quantitative yields whilst employing pharmaceutically acceptable reagents and solvents.

Disclosed are novel isoflavone derivatives having the structure of Formula I

which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

The invention concerns novel flavone and isoflavone derivatives of formulae (Ia) and (Ib) wherein: X represents a group of formula —COOR, or —PO(OR)₂; R represents a hydrogen atom or an alkaline or alkaline-earth metal, or a lower alkyl group; R₁ represents a hydroxy group, a lower alkoxy group or an acyloxy group; R₂ and R₃, identical or different, represent a hydrogen or halogen atom, or a trifluoromethyl group, a trichloromethyl group, a hydroxy group, an alkoxy group or an acyloxy group comprising 1 to 5 carbon atoms, or R₂ and R₃ can combine to form an alkylene dioxy group. The invention is useful for rheumatic diseases.

The invention discloses an isoflavone derivative, which specifically is a compound shown as formula (I), or its solvate, or its pharmaceutically acceptable salt. Specifically, R1-R3 are independently selected from alkyl of C1-C6 respectively, and M represents alkali metal or hydrogen. Experiments prove that the compound provided by the invention has anti-Coxsachie virus effect in test mice, and has effects superior to those of control drugs under high, medium and low doses. Therefore, the compound provided by the invention can be used for preparation of anti-Coxsachie virus drugs, and has simple and efficient preparation method, thus having broad market prospects. (formula (I)).

Isoflavones are modified by esterification at one or more of the C4′, C5, C6, and C7 positions to promote bioavailability, and especially to enhance solubility over the corresponding unesterified isoflavones. Preferred modifications produce a carboxylic acid hemiester or a phosphate ester which is biologically hydrolysable. Preferred starting isoflavones are genistin and daidzin, and still more preferably comprises an aglycone form such as genistein or daidzein. Esterified isoflavones may be employed therapeutically or prophylactically for a variety of conditions, provided as a dietary supplement, or added to natural or processed food-stuffs. Further preferred uses include incorporation of contemplated compounds into topical formulations, and especially cosmetic topical formulations.

The invention discloses a calycosin derivative and a synthesis method thereof. The derivative is prepared by the steps of: dissolving a compound 1 and a compound 2 in an organic solvent, making the compound 1 and the compound 2 react under a basic condition to obtain an intermediate product 3, and dissolving the intermediate product 3 and a compound 4 in an organic solvent to obtain the targeted crude product. Applicants find that the proliferation of human umbilical vein endothelial cells can be promoted by the derivative of low concentration, so that an effect of good vascular protection isachieved, and therefore the derivative can be applied to the preparation of ERalpha and GPR30 agonists; meanwhile, an inhibitory effect on MCF-7 cells can be generated by the derivative of low concentration (10 uM); the structures of the compound 1, the compound 2, the intermediate product 3 and the compound 4 which are involved in the derivative and the synthesis method of the derivative are shown as follows respectively.

The invention relates to a Vegetable estrogen analogy composition capable of replacing estrogen and its application, wherein the composition includes various isoflavones, isoflavone derivatives and phenol substance extracted from a plurality of plants, Chinese medicinal herbs and leguminous plants which has the function of estrogenic hormones.

The invention belongs to the field of medical technology and discloses a genistein derivative with a structure shown by formula I in the specification or a pharmaceutically acceptable salt thereof. The invention also discloses an application of the genistein derivative or the pharmaceutically acceptable salt thereof in preparing a tumor treating medicine, an application in preparing an inflammation-related tumor treating medicine and an application in preparing a medicine inhibiting tumor cell invasion and migration. The genistein derivative disclosed by the invention generates a growth inhibiting and killing effect on tumor cells to realize an anti-tumor effect and has broad-spectrum anti-tumor activity while the effect is relatively good; the genistein derivative promises a perfect treatment effect on the AOM/DSS induced inflammation related tumor; and with relatively good ability of inhibiting tumor cell invasion and migration, the genistein derivative can be used for preparing a medicine inhibiting tumor migration and can be made into tumor migration inhibiting medicines of various dosage forms, thereby providing a better choice for tumor patients.

The invention relates to a 7,4'-disubstituted isoflavone derivative and a preparation method and application thereof. The structural formula is shown in the specification, wherein R is 2-hydroxyl-3-di-n-propylaminly propyl, 2-hydroxyl-3-piperidyl propyl, 3-dimethylamino propyl or 3-diethylin propyl. The preparation method of the compound is simple and high in yield. The compound prepared according to the invention has good antitumor activity in vitro.

This invention belonging to chemical field is about preparation of high water-solubility soybean isoflavone and its derivative. By using cyclo-glucosyl transferase as enzyme and the highly dense starch as glycosyl donor, we convert natural soybean isoflavone to polysaccharide-isoflavone mostly complexed with cyclo-glucosyl. This invention is advantageous in high water-solubility compared with the natural ones. At the indoor temperature, its dissolvability is 95.2mM, 222 times higher than the natural soybean isoflavones. In the procedure, the aglycone structure hasn't been changed to remain natural activity in maximum. After filter and sterilization, the products could be injection, oral liquid and powder injection with cryodesiccation. It could be used in tumor (especially mammary cancer and prostate cancer), hectic fever, osteoporosis, hyperlipoidemia and so on. It overcomes the previous soybean isoflavone which could only be oral and which is low in biological effectiveness and therapeutic efficacy.

The invention discloses a composition of multiple isoflavone derivatives, and further discloses a preparing method of the composition and medical application of the composition in treating diabetes. The composition of the isoflavone derivatives is prepared by carrying out structural modification on 4,7-diacetyl isoferulic acid genistein, 7-2-bromo-ethoxy genistei and a genistein vanadyl complex. Results of administration hypoglycemic activity screening and cell activity experiments show that the composition has a very good hypoglycemic effect which is better that that of single compounds, and can be used for preparing medicine for treating type II diabetes.

The invention relates to the field of medicinal chemistry, aims to provide a substituted furan isoflavone derivative and a preparation method thereof. The substituted furan isoflavone derivative has a structure represented by the formula (I), wherein R1 and R2 are separately independently selected from the group consisting of a hydrogen atom, methyl, methoxyl or halogen. The product is a natural furan isoflavone analogue having a novel skeleton, and has potential pharmaceutical activity; the preparation of the compound can provide a support for research of the pharmaceutical activity of furan isoflavones; the preparation method has the advantages of simple steps and low loss rate and has great significance for industrialized production.