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Vegetable estrogen analogy composition capable of replacing estrogen and its application

An estrogen, natural plant technology, applied to the estrogen replacement madam and its application fields, can solve problems such as breast cancer and cervical cancer, and achieve the effects of regulating metabolism, increasing bone density, and delaying aging

Inactive Publication Date: 2005-07-06
天津市合大基因营养调控技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In the past, people used estrogen to inject or take oral estrogen, but it was found that this method could easily lead to breast cancer and cervical cancer.

Method used

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  • Vegetable estrogen analogy composition capable of replacing estrogen and its application
  • Vegetable estrogen analogy composition capable of replacing estrogen and its application
  • Vegetable estrogen analogy composition capable of replacing estrogen and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The ratio used by Mrs. Testrogen: Pueraria isoflavones 45%, Genistein 35%, Pueraria estradiol 10%, Pseudomestrolactone 10%, Active calcium trace, Pueraria starch, Vitamin D 3 Trace.

[0050] Experimental method: Take 80 mature female mice, 60 were ovariectomized, and 20 were sham-operated without ovariectomy. As a normal control, 60 ovariectomized mice were divided into 3 groups. The first group received no drug administration, and the second group received estrogen. (E 3 - the estrogen drug diethylstilbestrol), the third group was given the above-mentioned proportion of the present invention, and was killed after 4 months and 7 months of feeding respectively, and the bone density BMD and bone mineral content BMC were measured. Experimental results:

[0051] Effects on BMC and BMD in ovariectomized rats

[0052] Group Dose Number of animals 4 months 7 months

[0053] (mg / kg) (only) BMC(g) BMD(mg / cm 3 ) BMC(g) BMD(mg / cm 3 )

[0054] Sham operat...

Embodiment 2

[0061] The ratio used by Mrs. Tianestrogen: Genistein 70% Pueraria Isoflavone 20% Soy Isoflavone 10% Vitamin D 3 , soybean protein, and trace amounts of active calcium.

[0062] Experimental method: 40 post-weaning female rats with an average body weight of 66.61 grams were randomly divided into four groups, 10 in each group.

[0063] Group A high-dose experimental group (basic feed + the above-mentioned ratio of 41.6mg / kg)

[0064] Group B medium dose experimental group (basic feed + the above-mentioned ratio of 25.0mg / kg)

[0065] Group C low-dose experimental group (basic feed + the above-mentioned ratio of 12.5mg / kg)

[0066] Group D control group (basic feed)

[0067] The above-mentioned four groups of rats were decapitated after 12 weeks of culture, and bone phosphorus, bone calcium, bone mineral content (BMC) and bone mineral density (BMD) were detected, and the results were as follows:

[0068] Test items

A

B

C

D

Bone calcium conte...

Embodiment 3

[0075] The ratio used by Mrs. Estrogen: pseudoestrolactone 50% pueraria isoflavone 40% genistein isoflavone 10%, vitamin D 3 Active calcium, Pueraria starch trace.

[0076] Experimental method: Take 40 3-month-old SD female mice, with an average body weight of 200±10g, and divide them into 4 groups, 10 rats in each group. Group A is sham-operated, groups B, C, and D are ovariectomized, and the basal diet of group C is increased by this amount. The wife's estrogen 100mg / kg of embodiment proportioning, every day, D group basal feed adds western medicine [Natelin (sodium etidronate) that inhibits bone resorption] 10mg / kg, every day, change clothes stimulation after taking medicine 2 weeks Bone formation drug (simvastatin) 5mg / kg, every day, supplement CaCO at the same time during the bone formation phase 3 100mg / kg, daily, vitamin D 3 21IU / kg, every day, after raising for 10 weeks, decapitate, measure serum estradiol (E 2 - represents estradiol) and osteocalcin (BGP) in serum,...

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Abstract

The invention relates to a Vegetable estrogen analogy composition capable of replacing estrogen and its application, wherein the composition includes various isoflavones, isoflavone derivatives and phenol substance extracted from a plurality of plants, Chinese medicinal herbs and leguminous plants which has the function of estrogenic hormones.

Description

technical field [0001] The present invention relates to the application of health products for middle-aged and elderly people, especially the estrogen substitute of estrogen and its application. Drugs and phenolic substances, which have the function of estrogen, are used to replace and supplement the deficiency of estrogen in middle-aged and elderly women. Background technique [0002] Estrogen plays a decisive role in the growth, development, reproduction and aging process of women. [0003] During puberty, the growth and development of sexual organs are determined, the fallopian tubes, uterus, and vagina are enlarged and lengthened, fat is deposited in the mons pubis, labia majora, and labia minora, the blood circulation is rich and swollen, the mitosis of the vaginal epithelium increases sharply, and the thickness of the epithelium increases. At the same time, it also promotes the formation of female secondary sexual characteristics: development of mammary gland matrix, ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P3/06A61P9/10A61P9/12A61P19/10A61P35/00
Inventor 蒋谷人张梅蒋怀阳
Owner 天津市合大基因营养调控技术有限公司
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