128results about How to "Has anticancer activity" patented technology

The invention relates to a zinc phthalocyanine complex and a preparation method thereof. The complex is (8-(7-coumarin oxygroup)-3,6-dioxoa-1-octyloxy; and the molecular formula of the zinc phthalocyanine complex is C42H32N8O6Zn. Coumarin oxygroup with a long alcoxyl chain is introduced at the periphery of the large ring of the zinc phthalocyanine, amphipathicity and biocompatibility of the zinc phthalocyanine complex are improved, and a photodynamic activity is improved. The zinc phthalocyanine complex is difficult to gather and favorable for improving cell intaking rate, and the photodynamic activity is improved; coumarin has an antitumor activity, and the coumarin is combined with photodynamic, so that the zinc phthalocyanine complex is favorable for serving as a photodynamic clinical medicine. The structure of a compound of the zinc phthalocyanine complex is single, and the compound is free from isomers, so that a product is easy to extract; and a synthetic method is simple, the side reaction is small, the yield is high, raw materials are readily available, cost is low, and industrial production is facilitated.

The invention discloses 5-iodine-4-sulfur-2'-deoxyuridine, and derivatives and a synthetic method of the 5-iodine-4-sulfur-2'-deoxyuridine. The synthetic method comprises the steps of using 5-iodine-2'-deoxyuridine as main raw material, treating by using acetic anhydride under a certain conditions to obtain 3', 5'-O-dioxo acetyl-5-iodine-2'-deoxyuridine, reacting under the action of phosphorus pentasulfide, then, introducing ammonia to saturated methanol solution, stirring and deprotecting at the room temperature to obtain 5-iodine-4-sulfur-2'-deoxyuridine. According to the invention, the compound and the derivatives have greatest absorption with the ultraviolet spectrum at 345 nm and stronger UVA photosensitivity. Therefore, the compound provided by the invention is a new basic base sulfur-containing nucleosides compound, can alternatively acts on cancer cells and has potential medical value; besides, the synthetic method provided by the invention has the advantages of simple reaction conditions, accessible raw material, low cost, high product yield, high purity and high efficiency.

A method for preparing deoxyfructosazine through chitin biomass comprises the following steps: uniformly mixing a dry chitin biomass raw material, an imidazole ionic liquid solution and an additive in a dimethyl sulfoxide reaction medium for reaction to obtain an intermediate product; adding a crystal solvent in the intermediate product to completely dissolve the product, performing hot filtration to remove insoluble impurities, performing rotary evaporation concentration on a filtrate, and performing recrystallization to obtain the product, namely the deoxyfructosazine. The method has the advantages that the raw material source is wide, pollution is avoided, the preparation is simple, and the product purity is high.

The invention discloses a method for preparing a nitrogen-containing heterocyclic ring compound by use of chitin biomass. The method comprises the following steps: uniformly mixing a chitin biomass raw material, an imidazole type ionic liquid solution and an additive for reaction, sequentially adding acetic oxide and pyridine into a reaction product for acylation, quenching the acylation-finished reaction liquid, adding an extracting agent into the acylation-finished reaction liquid for extraction, rotationally evaporating and concentrating to obtain an acylation product, adding an NaOH solution into the acylation product which is obtained through the extraction, stirring under a water-bath condition, adding hydrochloric acid which has the same molar weight as alkali, adding methanol, filtering to remove inorganic salt, rotationally evaporating and concentrating the filtrate to obtain a deacylation product, and crystallizing the deacylation product. The method disclosed by the invention has the advantages of simple process, high product purity, high yield and short reaction time.

The invention discloses cation amphiphilic membrane targeted alpha-helix polypeptides and an application thereof. The polypeptides comprise an amino acid sequence [X1X2X3X1X2X3X1]n-NH2, wherein NH2 represents amination of C terminal; X1 is polar amino acid with positive charges; X2 and X3 are nonpolar hydrophobic amino acids; n is a positive integer; and all amino acids are L type amino acids. According to the invention, a series of cation amphiphilic membrane targeted alpha-helix polypeptides are provided, and have anti-cancer activity; different types of hydrophobic amino acids (L, I, F, A and the like) are remarkably different in the membrane action effect; and if the concentration is higher than the key micelle forming concentration, the hydrophobic amino acids can be self-assembled into a micro-micelle to generate a violent cell killing effect, and a new basis is provided for the development of anti-cancer drugs.

The present invention relates to a recombinant plasma membrane-based vesicle, and more specifically to a recombinant plasma membrane-based vesicle comprising a VSV-G mutated protein in which histidine, which is the 162nd amino acid in the membrane, has been replaced with arginine, and a pharmaceutical composition, for treating cancer, comprising the recombinant plasma membrane-based vesicle.

The invention relates to dama-20S, 25S-epoxy-3beta, 12beta, 26-triol, as well as an extracting method and a pharmaceutical application thereof and belongs to the field of medicines. The extracting method comprises the following steps: getting proper amount of the American ginseng stem, adding 3-8 times of 60-95% ethanol, heating, performing reflux extraction, extracting 50L for 3-6 hours each time and for 5-7 times, combining the extracting solution, and recovering the solvent till the solvent does not exist; performing silica gel column chromatogram on the ethanol extractive with an eluent comprising CHCl3 and MeOH at a ratio of 90-120:10-30, performing C18 reversed-phase column chromatography with an eluent comprising MeOH and H2O at a ratio of 80-90:20-10, and recrystalizing with ethanol and water in the ratio of 2:4-6 to obtain the Dama-20S, 25S-epoxy-3beta, 12beta, 26-triol. The compound not only has an antitumor activity, but also has the pharmacological actions for treating the coronary heart disease, the myocardial ischemia, the ischemia shock, the arrhythmia and the reperfusion injury, and can be used for preparing the medicines for treating the coronary heart disease, the myocardial ischemia, the ischemia shock, the arrhythmia and the reperfusion injury and the medicines for resisting liver cancer, mammary cancer, cervical carcinoma and astroglioma; besides, the compound has the characteristics of wide action scope and obvious effect.