44 results about "Diamino acid" patented technology

The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular antigens. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the B cell epitope or within the T-helper epitope.

Disclosed herein are methods and compositions for identifying and / or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.

The invention discloses a synthesis method of (2S, 3S, 4S)-5-(3, 4-diamino-thiophane-2-group) valeric acid, while prior method has long reaction and partial decomposition of product in reaction caused by concentrated halogen acid, to affect the quality of d-biotin. The invention processes reflux reaction on diethyl malonate condensate, cyano compound or bis-benzyl biotin in halogen acid, adds glacial acetic acid later, refluxes until no single-benzyl biotin and d-biotin exist in product, concentrates to remove unreacted halogen acid and glacial acetic acid, adds absolute ethyl alcohol, freezes to 0-5DEG C, adds lithium hydrate to neutralize and precipitate white solid crystals, filters, poaches filter cake via absolute ethyl alcohol, and dries to obtain target product. The invention has short reaction and controllable reaction end, which leads glacial acetic acid in later reaction to effectively avoid diamino acid being decomposed in concentrated halogen acid, to improve product yieldand content.

The invention discloses a co-catalyzing preparation method of alpha, betal-diamino acid derivative of alpha-quaternary carbon. The alpha, betal-diamino acid derivative of alpha-quaternary carbon is synthesized by a reaction of three components: aryl acetic acid ester diazonium, arylamine, and sulfamide imine under co-catalysis of rhodium acetate squaric acid amide or metal magnesium salt. The alpha, betal-diamino acid derivative of alpha-quaternary carbon comprises a threo form alpha, betal-diamino acid derivative of alpha-quaternary carbon and an erythro form alpha, betal-diamino acid derivative of alpha-quaternary carbon shown as formula (II). The raw material provided by the invention is low in cost and easily available, and two chiral carbons are constructed at the same time by a one-pot method. The method is short in preparation line, simple to operate, mild in reaction condition, easy to synthesize the catalyst, high in atomic economy, high in yield and free from environmental pollution, and the threo form or / and the erythro form alpha, betal-diamino acid derivative of alpha-quaternary carbon can be conveniently obtained at the same time. A diversified compound framework is provided, and the method has important meaning on new medicine screening and pharmaceutical preparation technology.