100 results about "Elemene" patented technology

The invention discloses an essence with moss faint scent and applications thereof. The essence with moss faint scent comprises following ingredients: orcinol monomethyl ether, divarinol monomethyl ether, ethyl everninate, methyl divaricatinate, beta-orcinol carboxylic acid methyl ester, orcinol carboxylic acid ethyl ester, ethyl divaricatinate, pinocarveol, bata-elemene, propylene glycol, and the like. Inherent aroma compounds of natural plant essences with moss faint scent are applied in the preparation of the essence of the invention, and the essence with moss faint scent is prepared by such steps: dissolving the ingredients, and allowing the mixture to stand. Technologies are simple and are easy to operate; ingredients are easy to obtain; cost is low; operability is high; scent lasting time is long; scent quality is high; the moss faint scent is true to nature; the essence of the invention can be used as a substitute of natural moss faint scent essences so as to reduce the demand for natural essences, and possesses promising application prospect in the fields of daily use essences and cigarette essences.

A beta-elemene pyrimidine derivative series is disclosd, which is prepared through reaction of beta-elemene on hypochlorite or NBS to obtain intermediate, and reacting on the pyrimidine's cyclic derivative in DMF or DMSO solvent.

The present invention discloses a kind of high-purity elemene medicine, which features the beta-elemene content as high as 98-99.9 wt%. One of its preparation process includes twice precise fractionation of elemene material containing beta-elemene of 80-92 wt% inside one heating reactor in precise fractionating tower with stainless steel cylinders as stuffing at vacuum degree of 200-500 Pa, flow rate ratio of 5 to 1 to collect the fraction at temperature of 82-83 deg.c. One other preparation process includes twice precise fractionation, and column chromatographic separation to eliminate impurity with the chromatographic column stuffed with silica gel after activation at 115-125 deg.c for 1.5 hr, and has even high beta-elemene content.

The invention discloses a phthorimaea operculella zell attractant comprising the following components in parts by volume: 8-10 parts of alcohol compound, 0.5-1.5 parts of ester compound, 2-3 parts of aldehyde compound, 1-3 parts of terpene compound and 0.1-0.5 part of other compound, wherein the alcohol compound is any one of 1,8-eucalyptol and palustrol; the ester compound is any one of methyl jasmonate, anti-4, cis-7-C13 diene acetate and anti-4, cis-7, 10-C13 triene acetate; the aldehyde compound is any one of heptaldehyde, octyl aldehyde and nonaldehyde; the terpene compound is any one of limonene, phellandrene, terpinene, caryophyllene, pinene, elemene, ocimene, germacrene, farnesene and isolongifolene; and the other compound is any one of nicotine, solanone, norsolandione and para-cymene. The attractant is environment-friendly, does not injure natural enemies of pests and has remarkable attracting effect on phthorimaea operculella zell adults.

The invention relates to a method for extracting and separating beta-elemene, a device thereof and a method for preparing a filling thereof. The method for extracting and separating the beta-elemene provided by the embodiment of the invention comprises the steps as follows: the raw material of the beta-elemene is added to the upper end of a chromatography column, wherein, the chromatography column is provided with silver nitrate surface modification filling; eluent is added into the chromatography column to elute the mixed raw material of the beta-elemene and the filling; solution after the elution is collected at times; and silver ion in the solution which is collected at times after the elution is removed. In addition, the embodiment of the invention also provides the device used for extracting and separating the beta-elemene and the method for preparing the silver nitrate surface modification filling which is used in the method for extracting and separating the beta-elemene.

The invention discloses a preparation method and applications for a polydopamine coated mesoporous silica/elemene composite nanoparticle preparation. The preparation method includes dropwise adding anelemene and ethanol mixed solution into a mixed solution of mesoporous silica and deionized water under room temperature, performing centrifugation for 3 min after performing stirring for 4 h, and removing supernatant to obtain mesoporous silica/elemene composite nanoparticles; dropwise adding a mixed solution of the composite nanoparticles and the deionized water into a Tris buffer solution containing dopamine salt, performing stirring for 12 h at the room temperature, performing centrifugation for 3 min, and performing washing for 3 times with the deionized water; and obtaining polydopaminecoated mesoporous silica/elemene composite nanoparticles. The method can prepare polydopamine coated mesoporous silica/elemene nano-composite materials with different mass fractions. Through the showing of solid ultraviolet test results, good ultraviolet absorption can be achieved after polydopamine coats mesoporous silica/elemene nanoparticles, so that the nano preparation cannot be easily swallowed by a reticuloendothelial system and has good sustained release effects.

The invention discloses Beta-elemene amino acid derivatives as shown in the formula I and the salt accepted pharmaceutically, the synthesis method of the Beta-elemene amino acid derivatives and the usage in preparing anticancer drugs; wherein, in the formula I, R[1], R[2] are independently H or amino acid with one hydrogen atom substituted on amino; the condition is H when R[1] and R[2] are different. The synthesis method of the Beta-elemene amino acid derivatives in the formula I and the salt accepted pharmaceutically has the advantages of having good water soluble and biocompatibility and higher anticancer activity compared with Beta-elemene and an important reaction intermediate. The synthesis method can be used as synthesizing other Beta-elemene derivatives.

The invention relates to a combined drug, in particular to a combined drug with anti-tumor activity. The drug comprises elemene substances with anti-tumor effect, nonsteroidal substances with anti-inflammatory effect and one or more medicinal carriers. Such synergic combination ensures the combined drug to have better anti-tumor activity.

The invention discloses an elemene injection. One liter of the injection consists of the following raw materials: 5 to 20 grams of elemene, 15 to 60 grams of soybean lecithin for injection, 5 to 99.9 grams of oil for injection, 12 to 30 grams of glycerol for injection, and the balance of phosphate buffer solution. The invention also discloses a method for preparing the elemene injection. By controlling the content of lysophosphatide in an auxiliary material, namely soybean lecithin, and key preparation process conditions, an anti-cancer medicament, namely the elemene injection, is prepared, which has no hemoclasis, no vascular irritation and no risk of the survival of microorganisms after the sterilization, is suitable for intravenous injection or arterial intervention, has a dosage form of medicament-loaded emulsions, and is safe and effective.

The invention discloses a molecularly compatible pharmaceutical composition of docetaxel and elemene and application thereof. The docetaxel and elemene are in a mass ratio of 20-1000. The compositioncan be applied to treatment of breast cancer, lung adenocarcinoma, colon cancer, gastric cancer and prostate cancer, and especially has very good treatment effect on taxane drug-resistant breast cancer, taxane drug-resistant lung adenocarcinoma and taxane drug-resistant colon cancer. During application to preparation of drugs treating taxane drug-resistant tumors, the molecularly compatible pharmaceutical composition has significant anti-paclitaxel resistance effect, also can remarkably reduce the toxicity and greatly alleviate the pain of tumor patients. The pharmaceutical composition provided by the invention provides a new strategy for drug-resistant tumor treatment, and has important significance and broad application prospects for drug-resistant tumor treatment.

The invention provides a method for extracting delta-elemene. The method comprises the following steps of: (1) carrying out ordinary rectification by using zedoary turmeric oil of which the delta-elemene content is more than 1.5% as the raw material, wherein the vacuum degree inside a rectifying column is 150-300Pa and the rectification ratio is 2:1, and collecting distillate with a temperature of 128-135 DEG C; (2) carrying out primary fine rectification by using the distillate obtained in the step (1) as the raw material, subsequently carrying out the secondary fine rectification by using the obtained distillate as the raw material, wherein the rectification ratios are different (4:1 in the primary fine rectification, and 6:1 in the secondary fine rectification) and the vacuum degrees in precise rectifying columns are both set as 50-150Pa, and collecting distillate with a temperature of 120-125 DEG C; and (3) carrying out axial compression high pressure column separation by using the obtained distillate in the step (2) as the raw material. According to the method, a method of primary ordinary rectification, secondary precise rectification and axial compression high pressure column separation is utilized, delta-elemene with high purity is obtained, and the difficult problem that no reference substances of the delta-elemene are available for years is solved.

The invention relates to a pharmaceutical composition, characterized in that it comprises, as an active substance, a combination of beta-elemene, lupeol and a pharmaceutically active agent selected from cinnamaldehyde, 2-hydroxycinnamaldehyde, 2'- benzoyloxycinnamaldehyde, beta-sitosterol, curcumin and the mixtures thereof.

The invention discloses beta-elemene macrocyclic derivatives as well as a preparation method and application thereof in preparation of antitumor drugs. The structure of the beta-elemene macrocyclic derivative is as shown in any one of formulas (I)-(III).

The invention belongs to the technical field of medicines, and provides a medical compound containing borneol. The medical compound contains germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The medical compound containing borneol is definite in ingredients and controllable in quality; the content of camphol in the borneol is controlled, so that the blood concentration and the mucosa absorbing rate of the medical compound are improved; the medical compound provided by the invention can be used for preparing suppository, ointment, capsules, effervescent tablets, gels, lotions, film agents or foaming agents; and the medical compound provided by the invention can well treat HR-HPV (high-risk human papilloma virus) and/or LR-HPV (low-risk human papilloma virus), cervical disease and the like, and is suitable for wide clinical application.

An exterior-applied elemene medicine with slow release and low irritation is proportionally prepared from elemene, organic solvent, medicinal matrix, and the additive chosen from hyaluronic acid, sodium hyaluronate gel, hyaluronidase, carbomer, and chitin. Its preparing process is also disclosed.

The invention provides a method for detecting beta-elemene and related substances thereof, which comprises the following steps of: performing isocratic elution by taking a polysaccharide derivative ofwhich the surface material is amylose-tris (3-chloro-5-methylphenyl carbamate) as a filler and acetonitrile water as a mobile phase. According to the method, beta-elemene can be effectively separatedfrom adjacent impurities and all the impurities, the reproducibility is good, beta-elemene and related substances thereof can be accurately detected, the problem that beta-elemene and related substances thereof are difficult to separate is effectively solved, and therefore it is guaranteed that the quality of beta elemene is controllable.

The invention relates to a detection reagent kit and method of heat-resistant microorganisms in elemene lipidosome injection semi-finished products and belongs to the technical field of medical instruments and detection means. The detection reagent kit contains sterile elemene standard injection and heat-resistant microorganism biological indicator. The detection steps include S1 screening heat-resistant microorganisms in the elemene lipidosome injection semi-finished products by the boiling water bath; S2, separating, identifying and storing heat-resistant bacteria of bacillus; S3, preparing spore liquid of the heat-resistant bacteria prepared in the step S2, and calibrating concentration of spore liquid; S4, preparing biological indicator by products obtained in the step S3, and calibrating concentration of the biological indicator; S5, boiling quantitatively. The detection reagent kit fills the blank of the related technology and forms the detection technology of a complete closed loop from inspection, evaluation and treatment of heat-resistant microorganisms. The detection reagent kit helps detectors detect the pollution state of elemene, labor is saved, and detection efficiency is improved.