33 results about "Germacrone" patented technology

A formulation, method and system for the topical, transdermal or transmucosal administration of a therapeutically effective active agent. Particularly, the invention provides a formulation, system and method for enhancing the permeation or penetration of active agents across the dermal or mucosal surfaces of a mammalian subject. The formulation includes a plant extract of the genus Curcuma of the family Zingiberaceae, a germacrone, or a natural or synthetic constituent thereof, which has been found to increase penetration of the active agent across the dermal or mucosal surface. If desired, a secondary permeation enhancer of a polyalcohol, a monoalkyl ether of diethylene glycol, a tetraglycol, or a mixture thereof can be used for certain active agents for optimal permeation enhancement.

The invention relates to a rapid center control testing method of Xingnaojing injection. The rapid center control testing method comprises the following steps of: (1) acquiring samples of primary distillate and secondary distillate in the preparation process of the Xingnaojing injection of different batches; (2) testing the areas of the curcuma zedoary diketone, the curcumenol and the Germacrone in the distillate samples and the total liquid phase peak areas by using a liquid chromatographic method, and testing the muscone peak areas in the distillate samples by using a gas chromatographic method; (3) acquiring near infrared spectrum data of the distillate samples; (4) constructing a model; and (5) testing the content of the curcuma zedoary diketone, the curcumenol, the Germacrone and the muscone in unknown distillate samples.

The invention discloses a high quality and yield culture technology of curcuma zedoaria, which comprises the following steps: land selection and preparation, seed curcuma preparation, sowing, field management, harvesting and prevention and cure of plant diseases and insect pests. The technology of the invention is characterized in that: the rotation land or clay with neutral PH or micro acid in which curcuma zedoaria is not planted in the previous year is selected; prior to sowing, the rootstalk with two or three heads which has a diameter of more than 20mm and a length of more than 50mm, or a big curcuma which has the diameter of more than 15mm and the length of more than 70mm is selected as the seed curcuma, and the seed curcuma is sowed from May 20 to May 30 in a normal year; the planting density is 2700-3300 plants per mu with the row spacing of 0.45-0.50m; during sowing, fossias are dug in field, sowing is carried out according to the planting spacing of 0.45-0.50m. The bottom fertilizer is applied in the space between seed curcumas, and covering soil is carried out. The technology can improve the yield of the medicinal materials of zedoary root and radix curcume longae produced by curcuma zedoaria by 15%-20%, increase the content of curcuminoids, the content of germacrone, the content of naphtha by 15%-20%, 16%-20% and 10%-15% respectively, and increase the economic benefit by 15%-20%.

The invention relates to a method for preparing germacrone, which belongs to the field of the preparation of traditional Chinese medicines. According to the method, the germacrone is extracted and prepared from raw materials which are rich in the germacrone. The preparation method comprises the following steps of: after primarily processing the raw materials which are rich in the germacrone, performing ultrasonic extraction by using an organic solvent at the temperature of below 45 DEG C; performing rotary evaporation and concentration to obtain extract; performing chromatography by using a silica gel-alumina composite column; performing gradient elution on the mixed solvent; recycling the solvent; and re-crystallizing by using petroleum ether-acetone or cyclohexane-ethanol to obtain the germacrone. By the preparation method, the germacrone has high yield; a closed system is adopted during extraction; solvent consumption is low; meanwhile, production safety is improved.

The invention provides an essence suitable for low-temperature non-combustion smoke products, a preparation method and an application thereof, and relates to the technical field of low-temperature non-combustion smoke products. The essence comprises components with antitussive and expectorant effect and the components with antitussive and expectorant effect is prepared from at least one of foliumArtemisiae Argyi oil, daurian rhododendron oil, oleum viticis negundo, alpha-asarone, Germacrone, P-Cymene, guaiacol sulfonic acid potassium, acetylcysteine, isofraxidine, esculetin, ligustilide, stachydrine, ligustrazine, imperatorin, isoimperatorin, Praeruptorin A, Praeruptorin B, Praeruptorin C, hygrine, and Cuscohygrine. The antitussive and expectorant active ingredient is natural active ingredient, which can volatilize and transfer to the total particulate matter of the smoke at atomization temperature, enrich the smoke and enhance the mouthfeel, and at the same time is partly absorbed bythe human body, so that the low-temperature non-combustible smoking product has the function of regulating the respiratory system function to a certain extent.

The invention discloses a medicine composition for treating pneumonia. The medicine composition is prepared from garlic, coptidis rhizomes, magnetite, Chinese siphonostegia herb, radix sophorae flavescentis, germacrone and bergenin according to a proportion. The medicine composition can be prepared into various dosage forms according to conventional preparation technologies and is significant in treatment effect when used for treating pneumonia.

The invention discloses a method for separating germacrone from Curcuma wenyujin volatile oil. The method comprises the following steps: fully mixing an aqueous solution of methyl-beta-cyclodextrin with n-hexane according to a volume ratio of 1:0.5-2, standing, carrying out liquid separation to respectively obtain an upper phase which is a mobile phase and a lower phase which is the stationary phase of a high-speed countercurrent chromatograph; and weighing the Curcuma wenyujin volatile oil, dissolving the Curcuma wenyujin volatile oil in a mixture containing the upper phase and the lower phase according to a volume ratio of 1:1, introducing the above obtained sample, carrying out high-speed countercurrent chromatographic separation, detecting through an ultraviolet detector, collecting corresponding effluents corresponding to peaks in the spectrogram of the ultraviolet detector, concentrating germacrone-containing effluents, and drying to prepare pure germacrone. The method has the advantages of simple operation, less solvent consumption, high efficiency, fastness, strong purposefulness and good separation effect.

The invention discloses a detection method for curcuma zedoaria in Fuping capsule. The detection method is characterized in that the curcuma zedoaria content is determined through gradient elution by using high performance liquid chromatography, wherein only the curcuma zedoaria in the Fuping capsule contains germacrone, such that the curcuma zedoaria content determination is exclusive. According to the present invention, the curcuma zedoaria content determination is performed in the Fuping capsule detection so as to effectively control the quality of the Fuping capsule.

The invention relates to a radix curcumae storage method, which comprises the following steps of (1) collecting side roots of fresh radix curcumae; eliminating fine roots, impurities and foreign materials; performing soaking by water for 5 to 10 min; brushing away soil and scar residues attached onto roots and stems; then performing flushing by flowing water for 0.5 to 1.5 min; (2) steaming the flushed radix curcumae for 1 to 2.5 h; (3) processing the radix curcumae by a far infrared drying method so that the water content is lower than 14 percent; (4) coating a glutin layer; then performing drying; (5) packaging the dried radix curcumae by a woven bag; putting the materials under the conditions of the temperature being 10 to 20 DEG C and the humidity being 51 to 53 percent. The method disclosed by the method has the advantages that curcuma zedoary oil and germacrone in the radix curcumae can be well retained; in the storage period, the moisture content increase speed and the reductionspeed of curcuma zedoary oil and germacrone content is slow; the effective storage time of the radix curcumae can be obviously increased.

The invention relates to a quality evaluation method of a five-ingredient capsule for warming and activating collaterals and eliminating arthralgia. 15 ingredients including coumarin, baicalin, epimedin C, icariin, cinnamic acid, wogonoside, cinnamyl aldehyde, baicalein, cinnamyl alcohol, 2-methoxycinnamyl aldehyde, wogonin, baohuoside I, dehydrated icariin, germacrone and pachymic acid are selected as quality markers of the compound; full-wavelength scanning detection is performed, and UHPLC quality evaluation is performed on WWCC (Wuwei Wuntong arthralgia-eliminating capsule) under two wavelengths of 203nm and 270nm; after the analysis method is established and verified, the 15 quality markers in the WWCC sample are quantitatively analyzed, a WWCC fingerprint spectrum under 270nm is constructed, and the overall quality evaluation of the WWCC sample is completed. The method provides a unique idea for WWCC comprehensive quality evaluation, and provides reference and demonstration effects for traditional Chinese medicine compound overall quality evaluation.

The invention provides a composition. The composition is composed of furandiene and germacrone. The invention also discloses an application of the furandiene-germacrone composition in preparation of medicines for treating psoriasis. The composition has a remarkable inhibition effect on content of NO released by LPS-induced RAW264.7 cells. The composition has remarkable effect of inhibiting proliferation of HaCaT cells. In-vitro tests prove that furandiene and germacrone have a remarkable curative effect on psoriasis and can be used for preparing medicines for treating psoriasis.

The invention provides perfume with a fatigue relieving effect and a preparation method of the perfume. The perfume is prepared from 5 to 15 parts of base oil, 10 to 25 parts of composite extracting solution, 1 to 3 parts of xylitol, 0.5 to 3 parts of PEG-40 hydrogenated castor oil, 1 to 5 parts of trimethyl isopropyl butyramide, 3 to 8 parts of beta-ethyl phenylacrylate, 1 to 4 parts of germacrone, 5 to 20 parts of lemon essence, 1 to 3 parts of jasmine essential oil, 1 to 5 parts of michelia alba essential oil, 65 to 85 parts of ethanol and 5 to 10 parts of deionized water, wherein the base oil is selected from one or more of grape seed oil, evening primrose oil and sandalwood oil; and the composite extracting solution is an extracting solution of maca (lepidium meyenii walp.) and tribulus terrestris.

The invention discloses a germacrone alcoholization and biological resolution method. The method comprises the following steps: by taking germacrone extracted from cedar branches and leaves as a raw material, carrying out reduction with sodium borohydride to obtain a compound II, carrying out enzymatic kinetic resolution reaction on the compound II to obtain a compound III and a compound IV, or carrying out dynamic kinetic resolution to obtain a compound III of which the yield is more than 90%, and hydrolyzing the compound III to obtain a compound V. According to the invention, a latent chiral ketone group in germacrone is further changed to a chiral hydroxyl center so as to carry out further resolution. The method disclosed by the invention has the characteristics of simple operation, high product yield, good optical purity and the like.