59 results about "Pachymic acid" patented technology

The present invention relates to a Chinese medicine Yangxin Anmian capsule preparation with the functions of nourishing yin, clearing away heat, nourishing heart and tranquilizing mind for curing the diseases of neurasthenia, neurosis, vexation and sleeplessness, profuse dreaming, dizzy head, tinnitus, limp aching lumbus and knees, etc. Said Chinese medicine capsule preparation is made up by using 10 Chinese medicinal materials of fresh deer's heart, fresh deer's blood, poria, spiny jujube kernel, longan flesh, schisandra berry and others and adopting traditional Chinese medicine preparation process.

The invention belongs to the technical field of extraction and purification of the effective parts of traditional Chinese medicines, and in particular discloses a preparation method of a total triterpene extract from poria cocos, comprising the following steps of: (1) weighing herbal pieces of poria cocos prepared for decoction, adding 60-80v / v% ethanol which is 4-8 times of the amount of the medicinal material and soaking for 3-12 hours, performing reflux extraction 1-3 times for 1-2 hours every time, combining the ethanol reflux extracting solutions; (2) performing suction filtration on theethanol reflux extracting solution to obtain filtrate; (3) concentrating the filtrate by flash evaporation till the relative density is 1.01-1.10, recovering the ethanol; and (4) spray drying the obtained concentrated solution to obtain the total triterpene extract product from poria cocos, collecting the dried extract, sealing, weighing and storing in a dry place. The method is simple, and the used solvent can be recycled, thus reducing the production cost and saving the energy source. The content of total triterpene in the extract prepared by the method is 31-58wt% counted by pachymic acid,and the extract has obvious anti-tumor and immunoregulation functions.

The invention relates to a preservative combination containing Chinese herbal medicine extract components and application thereof, which belong to the technical field of preservatives. The preservative combination contains 0.2 to 6.0 percent of active Chinese herbal medicine component, 92 to 99.6 percent of solvent and 0 to 2.1 percent of synergistic agent, specifically, the active Chinese herbal medicine component is a single compound or the mixture of a variety of compounds among berberine hydrochloride, epiberberine, jateorhizine, palmatin hydrochloride, laevosyringaresinol glucoside, stigmasterol, 7-methoxy-3-methyl-2, 5-hydroxy-9, 10-hydroxy, methylcyclodecane, nodakenetin, glycyrrhizic acid, pachymic acid, eburicoic acid and palmitic acid, the solvent is water, and the synergistic agent is one of citric acid, ethanol, vitamin B and vitamin C or the mixture of more than one of citric acid, ethanol, vitamin B and vitamin C. The preservative combination has a good preservation effect, does not have toxic and side effects, and also can be applied in the preparation of preparations for inhibiting staphylococcus aureus, mould, saccharomycete, saprophyte and colibacillus.

The invention discloses a method for extracting and preparing pachymic acid A and pachymic acid B from Poria Cocos peels. The method is characterized in that high-speed countercurrent chromatography is adopted to separate ethyl acetate extract powder of the Poria Cocos peels, wherein the stationary phase is the upper phase of an n-hexane / ethyl acetate / methanol / water mixture; and the mobile phase is the lower phase of the n-hexane / ethyl acetate / methanol / water mixture. The method for simultaneously extracting high-purity pachymic acid A and pachymic acid B from Poria Cocos peels is provided, high-speed countercurrent chromatography is adopted for crude extract of Poria Cocos peels, a solvent system is designed to effectively separate the pachymic acid A and pachymic acid B from total triterpenoids of Poria cocos respectively, and the solvent system is rapidly layered, and makes high-purity pachymic acid A and pachymic acid B separated and purified from the extract within 2 h.

The invention relates to application of pachymic acid A for preparing a diuretic medicine. Research results of the application show that pachymic acid A has a remarkable diuretic function on a water retention rat with normal saline burden, has a diuretic effect of retaining potassium and discharging sodium, and can provide a diuretic candidate medicine as a novel aldosterone antagonist or selective aldosterone receptor retardant in clinical application.

The invention belongs to the field of drugs, and particularly relates to an anti-depression drug and application thereof. The active ingredients of the anti-depression drug at least comprise friedelin, preferably, the active ingredients of the anti-depression drug include the friedelin and pachymic acid A. When the friedelin and the pachymic acid A are used as a composition, the weight part ratioof the the friedelin to the pachymic acid A in the anti-depression drug is (2-4):1. Oral tablets are preferably selected as the form of the anti-depression drug. The accessories of the oral tablets comprise hydroxypropyl methylcellulose, lactose, povidone K30, magnesium stearate and talcum powder. The drug has an improvement effect on the behavioral features, caused by chronic unpredictable mild stress, of a rat depression model.

The invention relates to a method for extracting pachymic acid and pachymaran from poria peel, wherein the method comprises the following steps: performing alcohol reflux extraction on poria peel, filtering, and concentrating the filtrate to obtain filtrate and filter residue; concentrating the filtrate and adding ethyl acetate for extraction; concentrating the extract, purifying on a silica gel column, and crystallizing to obtain pachymic acid; adding a sodium hydroxide solution into the filter residue, and performing reflux extraction; filtering; adding acid into the filtrate to regulate thepH value; adding alcohol for precipitation; washing the precipitate and drying to obtain pachymaran. According to the method, active ingredients in the poria peel can be fully utilized, high-purity pachymic acid and pachymaran can be obtained at the same time, the utilization rate of the poria peel is greatly increased, the problem of resource waste is solved, and the production cost is lowered.

The invention relates to a preparation method of a non-irritating composite moisturizing agent, which belongs to the technical field of daily chemicals. The present invention aims at the problem that the moisturizing ingredients in the current traditional skin moisturizing agents are mostly some chemical preparations, which will cause adverse reactions such as skin allergies and erythema while moisturizing the skin, and destroy and damage the tissue structure of the skin. Poria cocos and almonds are enzymatically hydrolyzed and subjected to high-pressure blasting treatment to extract pachymic acid, ergosterol, and bactericidal substances, which are mixed with the unique essential oils in almonds to prepare a moisturizer matrix, which is then mixed with bovine umbilical cord blood and added to Ganoderma lucidum spore powder It is fermented under strains to increase its skin-rejuvenating active substances and increase the hydrophilic matrix. Finally, it is mixed with natural preservative chitin and other additives to prepare chemical-free preparations, which are non-irritating to the skin and do not produce any adverse reactions. non-irritating complex moisturizer.

The present invention relates to a medicinal composition for treating senile dementia disease. Specifically, the medicinal composition for treating senile dementia disease comprises the following active ingredients and a pharmaceutically acceptable carrier; wherein the active ingredients are selected from the group consisting of pachymic acid, alpha-asarone, beta-asarone, tenuifolin, Onjisaponin B, Polygalaxanthone III, pachymaran, polysaccharide of rhizoma acori graminei, polysaccharide of Polygala tenuifolia and a combination thereof. Pharmacological experiments find that the medicinal composition has a good therapeutic effect on various animal models of senile dementia.

The invention discloses a structural formula of an LQC-Y as well as synthesis and an application thereof. Pharmacological experiments verify that the compound has a remarkable anti-tumor effect, wherein the single day maximum dosage of an LQC-Y3 mouse is 6000mg / kg. No toxic reactions happen within 14 days of continuous observation, thus, the drug is very high in safety and can be used for preparing drugs for preventing and treating cancers such as liver cancer and lung cancer. The structural formula of LQC-Y is as shown in the specification, wherein R represents sterides such as cholic acid, deoxycholic acid, ursodesoxycholic acid, chenodeoxycholic acid and hyodeoxycholic acid; triterpenoids such as oleanolic acid, ursolic acid, pachymic acid, glycyrrhetinic acid and glycosides; parietic acid, rheum emodin and other anthraquinone mother nucleus mono-substituted or multi-substituted structures; baicalein, baicalin and other flavone analogue compounds; shikimic acid, mono-substituted shikimic acid or multi-substituted shikimic acid; geniposidic acid and other iridoid acid derivatives; and paeonol, curcumin and structural derivatives.

The invention discloses a preparation method and application of Poria cocos acidic polysaccharide. The preparation method is a method of preparing Poria cocos acidic polysaccharide by taking degreasedPoria cocos powder as a raw material and an alkali solution as an extraction solvent, and conducting extracting for 2-12 hours at 20-50 DEG C under a stirring condition. The preparation process provided by the invention is simple to operate, low in cost and environment-friendly, and the obtained Poria cocos acidic polysaccharide is high in content and has an obvious effect of regulating immunity.

The invention relates to a method for increasing the yield of pachymic acid of poria cocos liquid fermented mycelium. The method comprises the steps of performing liquid fermentation on the a poria cocos bacterial strain ZJ2, and adding a masson pine extract, cellulose and composite vitamin B into a liquid seed culture medium and / or a liquid fermentation culture medium for poria cocos fermentation. By the method provided by the invention, the yield of the poria cocos mycelium can be optimized and maximized, the pachymic acid content of the mycelium is increased, industrialized production of the mycelium can be realized, the problem of damage to wild pine forest resource caused by the fact that poria cocos sclerotium is cultivated by pine tree pockets is solved, and foundation is laid and technical guarantee is provided for comprehensive development and industrialized production of the medical and edible value of the poria cocos ; the method is simple in process, effective and short in fermentation cycle, has application value in industrialized production, and can successfully fulfill the aim of obviously increasing the yield of the expression products.

A traditional Chinese medicine composition, made from cassia twig, poria, cortex moutan, Radix paeoniae alba, peach kernel in equal proportions. The traditional Chinese medicine composition comprises paeoniflorin, amygdalin, benzoylpaeoniflorin, cinnamic acid, paeonol, and cinnamaldehyde. The composition has the advantages of high production efficiency, high content of effective ingredients, high transfer rate of poria acid, reduced hygroscopicity, and improved dissolution of index ingredients.

The invention relates to an application of a pachymic acid A in preparation of a drug for treating a chronic kidney disease. A research result of an inventor shows that the pachymic acid A has a relatively good treatment effect on a rat model from which 5 / 6 kidneys are cut off. The pachymic acid A is capable of providing a novel candidate drug for treating the chronic kidney disease for clinical use.

The invention discloses a grape health-care beverage and a preparation method thereof. The preparation method comprises the following steps of taking semen cassiae, radix puerariae and poria cocos asauxiliary materials, and sequentially adding rhizopus chinensis and aspergillus niger fermentation liquor to perform glycolysis on radix puerariae and poria cocos tissues so as to promote release of functional substances; and mixing radix puerariae and poria cocos glycolysis substances with the semen cassiae and grape juice in a certain proportion, performing multi-strain mixed fermentation, performing filtration, performing blending, and performing sterilization so as to obtain the grape health-care beverage. Compared with a conventional grape beverage, the grape beverage produced by the method provided by the invention has the advantages that the contents of substances of puerarin, chrysophanol, pachymaran acid and the like in the grape beverage are obviously increased, so that the grapebeverage has favorable health-care functions of reducing blood sugar, tonifying the kidney, resisting oxidation, resisting fatigue, enhancing immunity and the like.

The invention relates to application of pachymic acid or pachymic acid derivative in preparing medicine for treating polycystic ovary syndrome and a medicinal preparation. The invention provides a newapplication of pachymic acid or a derivative thereof, which has a remarkably treatment effect for polycystic ovary syndrome, and does not have side effect. Pachymic acid is verified, by the embodiment of the invention, to be available in treating mice polycystic ovary syndrome, and can provide a new candidate medicine for treating polycystic ovary syndrome for clinic.

The invention relates to spleen tonifying and nerve soothing poria cocos tea and a production method thereof. The spleen tonifying and nerve soothing poria cocos tea is prepared from poria cocos, spina date seeds, folium photiniae, indian adenosma, Chinese yam, mint leaves, herba schizonepeta, peanuts, illicium difengpi, okra, aizoon stonecrop herbs and ligusticum wallichii rhizomes. The production method mainly includes the following steps that 1, the materials are prepared and cleaned up according to the formula; 2, drying and sterilizing are carried out; 3, the dried raw materials are selected by a ratio; 4, the raw materials are smashed, mixed and fried; 5, the raw materials are soaked and decocted for many times, and filtrate is extracted many times; 6, the filtrate is mixed and concentrated to obtain concentrated liquor, and the concentrated liquor is dried to obtain mixed powder; 7, a finished product is prepared through bagging and disinfecting. The spleen tonifying and nerve soothing poria cocos tea has the effects of tonifying the spleen, soothing the nerves, nourishing the spleen and tonifying middle-jiao and qi after being drunk for a long time.

The invention relates to use of compound pachymic acid in the pharmaceutical field. The product has the functions of decreasing the rejection reaction of a receptor to a graft after a transplant operation, protecting the stability of haemolymph cell mitochondrial membrane potential at the periphery of the receptor, reducing the apoptosis percentage of haemolymph cells at the periphery, stabilizing the quantity percentage of CD8 + lymph cells at the periphery, and reducing the apoptosis percentage of the haemolymph cells at the periphery and regulating the quantity percentage of CD4 + and CD8 + lymph cells under nontransplant conditions and so on, is used to reduce graft rejection reactions as well as regulate and stabilize the quantity, the proportion and the function of the lymph cells of organisms during the transplant of organs, tissues and cells of animals and human beings and so on.

The invention discloses a traditional Chinese medicine composition for benefiting qi and activating blood, protecting heart and nourishing lung, promoting sleep and preventing altitude sickness. The traditional Chinese medicine composition is made of the following compositions, specifically including: radix astragali, radix angelicae sinensis, radix platycodonis, kudzu vine roots, poria cocos, spina date seeds, smoked plums, licorice roots, radix angelicae dahuricae, rhizoma polygonati odorati, rhizoma curcumae longae, dried tangerine or orange peel, dates, white paeony roots, ginseng, stigmacroci, panax notoginseng, caulis polygoni multiflori and gastrodia elata. The traditional Chinese medicine composition has the beneficial effects that the medicines are in precise compatibility and reasonable composition, and take effects of activating blood and benefiting qi, protecting heart and nourishing lung, activating blood and dredging collaterals, promoting blood circulation in bodies, improving blood flows, and the like into play together; meanwhile, the composition is capable of improving the anti-hypoxic and anti-fatigue capability of an organism body, and reliving, preventing andtreating adverse plateau reactions and other complications caused on a plateau, oxygen supply is solved from human body oxygen demand principles, dryness hydropenia is solved from product properties,and both body demands and physiological needs can be met.

The present invention relates to a composition having efficacies of slimming body and reducing lipids. The composition is prepared by processing the following raw materials: lycopene, green coffee bean extract, coix seeds, smoked plums, wax gourd skins, poria cocos, semen ziziphi spinosae, radish seeds, mulberries, fructus cannabis, fructus aurantii, chrysanthemums, fructus sophorae and gynostemma pentaphyllum. The composition is used to be prepared into chewable tablets for consumptions, convenient, and good in tastes, and has extremely excellent health-keeping effects of slimming body and reducing lipids.

The invention discloses a traditional Chinese medicine active component composition for treating cardiovascular and cerebrovascular diseases. The traditional Chinese medicine active component composition is prepared by mixing two or three of pachymic acid, magnolol and 10-hydroxyl-removed gingerdione. Under the best combination, two or three components can be combined to remarkably reduce contentof TC, TG and LDL-C and increase content of HDL-C. After the two components are combined, four indexes cannot completely reach the blank control group level, but are close to the level of the blank control group. Three components can be combined for reducing the values of the four indexes or increasing the values to the blank control level.

The invention discloses a preparation method of fermented pachymic acid substitutional tea. The method comprises the following steps of taking phaseolus calcaratus as a culture medium raw material, inoculating poria cocos mycelia obtained by screening and expanding culture, performing culture, fermentation, drying and crushing, and adding traditional Chinese medicinal materials for compatibility to obtain the fermented pachymic acid substitutional tea. The used traditional Chinese medicinal materials include semen coicis, pericarpium citri reticulatae, folium mori, radix ginseng, red jujubes,folium nelumbinis, flos lonicerae, agastache rugosus and mint. The phaseolus calcaratus is used as the culture medium for poria cocos fermentation; and a prepared fermented product is different from traditional planted poria cocos, has strong fermentation sour taste, can obtain good taste after being directly brewed, and has the effects of clearing damp, resisting cancer and enhancing human immunity when being used in cooperation with other traditional Chinese medicinal materials. The pachymic acid tea micro-ecological fermentation process does not exist in the market and provides a new way for improving the absorption and utilization of poria cocos products by the human bodies.

The invention is applicable to the technical field of nutritious foods. The invention provides a special clinical nutrition formula food for lung cancer and a preparation method thereof. The formula comprises protein, polyunsaturated fat, vitamin A, vitamin C, vitamin E, vitamin D, reduced glutamine, dietary fibers, calcium, iron, copper, magnesium, zinc, selenium, chitosan oligosaccharide, glutamine, soy isoflavone, curcumin and pachymic acid. The formula raw materials are sterilized and are then subpackaged into a bottle to prepare the edible nutritional food. Aiming at the bad situations ofunreasonable diet structure, non-uniform nutrition and the like of lung cancer patients, the nutritional structure of lung cancer patients is improved and the body health condition is improved in anauxiliary manner mainly through diet regulation and control, supplementation of various vitamins and minerals and matching of medicinal and edible food and new resource food.

The invention discloses a health-care beverage and a preparation method thereof. The formula of the beverage comprises the following components in percentage by weight: 2-10 percent of reed stem, 2-10 percent of watermelon seed, 1-3 percent of indian buead, 1-2 percent of oriental waterplantain rhizome, 0.1-0.2 percent of an emulsifier and 0.02-0.025 percent of sodium citrate serving as auxiliary materials, and the balance of filtered water. The preparation method disclosed by the invention comprises collecting raw materials, extracting, blending, homogenizing, sterilizing and packing. The health-care beverage disclosed by the invention has rich and complete nutrition, and is rich in human body nutrient health-care components such as protein, fat, vitamin B2, lactoflavin, niconacid, pachman, pachymic acid, rhizoma alismatis acid and lecithin, and a plurality of trace elements such as potassium, calcium, phosphorus, selenium and the like. Through long-term drinking, the health-care beverage has the health-care effects of: resisting tumors, reinforcing immunity, resisting bacteria, promoting urination, reducing blood fat and blood sugar, reducing gastric acid and preventing pyloric channel ulcer.

Disclosed are the general structural formula of LQC-Y as well as the synthesis and use thereof. Pharmacological experiments demonstrated the marked antitumor effect of such compounds. Single day administration of LQC-Y3 to mice at a maximum dose of 6000 mg / kg showed no toxicity response during the 14-day continuous observation period, indicating the high safety of the compounds, and the compounds can be used to prepare medicaments for preventing and treating carcinomas such as liver cancer, lung cancer. In the general structural formula of LQC-Y, R represents steroid compounds such as cholic acid, deoxycholic acid, ursodeoxycholic acid, chenodeoxycholic acid, and hyodeoxycholic acid and so on; triterpenoid compounds such as oleanolic acid, ursolic acid, pachymic acid, glycyrrhetinic acid and glycosides thereof and so on; emodic acid, emodin and other mono-substituted or poly-substituted structures of anthraquinone parent nucleus; baicalein, baicalin and other flavonoid; shikimic acid, mono-substituted shikimic acid or poly-substituted shikimic acid; gardenia acid and other iridoid acid derivatives; paeonol, curcumin and structural derivatives thereof.

The invention discloses an in situ drug delivery system constructed by pachymic acid A and a preparation method and application of the in situ drug delivery system, and relates to drug delivery systems. The preparation method of the in situ drug delivery system comprises the steps that (1) a pachymic acid A solution is prepared as a solution A; (2) a doxorubicin hydrochloride solution is preparedas a solution B; and (3) the solution A is mixed with the solution B uniformly, and after standing, a stable PAA-DOX Gel drug-loaded gel is obtained, that is, the in situ drug delivery system constructed by the pachymic acid A is obtained. The gel prepared by the preparation method has a stable structure, PAA and DOX have a synergistic effect, high cytotoxicity is achieved, cancer cells can be killed even at low concentration, and natural product activity is exerted. Due to a special network structure of the PAA-DOX Gel, DOX can be wrapped in a gap of the gel, the spread of drugs is further prevented, and the drugs can be injected intratumorally to achieve persistent reserve and sustained release.

The invention discloses a veterinary drug for treating high-mortality lactation piglet diarrhea. The veterinary drug is prepared by the following raw materials in part by weight: 10-50 parts of poria peel, 10-50 parts of carbonized black plum, 10-50 parts of vinegar-fried radix paeoniae alba and 5-15 parts of honey-fried liquorice. The veterinary drug is safe and efficient and has controllable quality. The veterinary drug has the advantages that the poria peel, the carbonized black plum, the vinegar-fried radix paeoniae alba and the honey-fried liquorice are selected as the raw materials, the raw materials are natural traditional Chinese medicine, have a long clinical application history, and have small toxic and side effects and have no residue, and the natural traditional Chinese medicine raw materials and products thereof can be degraded in the natural environment and cannot cause environmental pollution; according to the clinical symptoms and the pathological change of the current high-mortality lactation piglet diarrhea, the treatment based on syndrome differentiation of traditional Chinese medicine is performed, the drug conforms to the characteristics of traditional Chinese medicine, and proved by experiments, the drug has remarkable effects; the product quality standards are made for the veterinary drug, and pachymic acid (C31H50O4) contained in the veterinary drug is not lower than 0.04 mg / ml; the quality is stable and controllable.

The invention relates to the field of pharmaceutical analysis, and provides a thin-layer chromatography identification method of a Danwei Kang capsule, which is characterized in that swertiamarin, wogonin, naringin, neohesperidin, alisol B, 23-acetyl alisol B and pachymic acid are added as reference substances; identification objects respectively point to seven thin-layer chromatography qualitative identification indexes of swertia mileensis, southwest scutellaria baicalensis, fructus aurantii, rhizoma alismatis and poria cocos which are main medicinal materials of a Danweishang capsule formula. Compared with the current drug standard of the Danwei Kang capsule, the method overcomes the technical defect that the current standard of the Danwei Kang capsule has few quality control points for identifying the medicinal materials of the prescription, and the provided identification item index is more comprehensive, strong in specificity, simple and rapid to operate, visual and clear in judgment and objective and reliable in conclusion, the invention provides a technical method for perfecting and improving the quality standard of the national medicine Danshenkang capsule and better controlling the quality of the medicine.

The invention discloses a preparing method for a diphenhydramine molecularly imprinted electrochemical sensor. A diphenhydramine molecularly imprinted electrochemical sensor with high-sensitivity anddrop-resistant doped zinc-nickel layered powder composite materials can be prepared by taking the diphenhydramine as a template molecule, taking the pachymic acid as a functional monomer, taking the azobisisobutyronitrile as an initiator, taking the zinc-nickel layered powder composite material as a dopant, taking the 4-cyclohexyloxy-4'-cyanobiphenyl as a sensing membrane modifier, and taking theoleuropein as a crosslinking agent. The analyzing method is simple and practical, and the defects that the prior analyzing method is complex, the equipment is expensive, and the sensitivity is low areovercome.