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Preparing method for diphenhydramine molecularly imprinted electrochemical sensor

A technology of diphenhydramine and molecular imprinting, applied in scientific instruments, instruments, analytical materials, etc., can solve the problems of inappropriate matching between functional monomers and template molecules, poor toughness and rigidity of cross-linked membranes, and low sensitivity. Achieve excellent sensitivity, simple equipment, and high sensitivity

Inactive Publication Date: 2019-02-12
GUANGXI UNIV FOR NATITIES
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AI Technical Summary

Problems solved by technology

The current method has low sensitivity and poor drop resistance because the selected functional monomers and template molecules cannot be properly matched, and the toughness and rigidity of the crosslinked film are also poor.

Method used

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  • Preparing method for diphenhydramine molecularly imprinted electrochemical sensor

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Embodiment 1

[0016] 1. Treatment of glassy carbon electrodes

[0017] The glassy carbon electrode was polished with 1.0 μm, 0.3 μm and 0.05 μm alumina powder on a polishing cloth in turn, then placed in nitric acid with a volume ratio of 1:1 for 8 minutes, and then placed in absolute ethanol for 8 minutes , and finally ultrasonically cleaned with pure water.

[0018] 2. Preparation of diphenhydramine molecularly imprinted electrochemical sensor

[0019] Prepare 20 mL of a mixed aqueous solution of nickel sulfate with a concentration of 0.25 mol / L, zinc sulfate with a concentration of 0.25 mol / L and vitamin C with a concentration of 0.5 mol / L with water as a solvent, and prepare a concentration of 0.05 mol with benzyl alcohol as a solvent. / L pentaerythritol diphosphite distearyl 5 mL, and then the prepared 5 mL pentaerythritol diphosphite distearyl solution was added dropwise at a speed of 5 drops / second to the above-prepared 20 mL nickel sulfate, zinc sulfate and vitamin C mixed soluti...

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Abstract

The invention discloses a preparing method for a diphenhydramine molecularly imprinted electrochemical sensor. A diphenhydramine molecularly imprinted electrochemical sensor with high-sensitivity anddrop-resistant doped zinc-nickel layered powder composite materials can be prepared by taking the diphenhydramine as a template molecule, taking the pachymic acid as a functional monomer, taking the azobisisobutyronitrile as an initiator, taking the zinc-nickel layered powder composite material as a dopant, taking the 4-cyclohexyloxy-4'-cyanobiphenyl as a sensing membrane modifier, and taking theoleuropein as a crosslinking agent. The analyzing method is simple and practical, and the defects that the prior analyzing method is complex, the equipment is expensive, and the sensitivity is low areovercome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a diphenhydramine molecularly imprinted electrochemical sensor. Background technique [0002] Diphenhydramine is an antihistamine. It has the effect of antihistamine H1 receptor, has a strong inhibitory effect on the central nervous system, and has atropine-like effect. It is suitable for allergic diseases of skin and mucous membranes, such as urticaria, hay fever, allergic rhinitis, etc., as well as sedation, It has hypnotic effect and can also be used to prevent motion sickness such as seasickness, motion sickness, and airplane sickness. However, long-term or excessive use of such drugs can cause side effects such as difficulty urinating or painful urination, dizziness, dry mouth, nasopharynx, upper abdominal discomfort or stomach pain, renal failure, and liver damage caused by drug sensitivity. The country lists it as a controlled drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327
CPCG01N27/3275
Inventor 谭学才韦贻春李浩陈其锋雷福厚余会成
Owner GUANGXI UNIV FOR NATITIES
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