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Preparation method of total triterpene extract from poria cocos

A technology of total triterpenes and extracts, which is applied in the field of extraction and purification of effective parts of traditional Chinese medicines, can solve the problems that there are no literature reports on the extraction process of total triterpenes of Poria cocos, and achieve the goal of reducing safety hazards, reducing production costs, and having no environmental pollution Effect

Active Publication Date: 2011-10-05
武汉回盛生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report about the extraction process of the total triterpenes of Poria cocos

Method used

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  • Preparation method of total triterpene extract from poria cocos
  • Preparation method of total triterpene extract from poria cocos
  • Preparation method of total triterpene extract from poria cocos

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation method of Poria cocos total triterpene extract, the steps are as follows:

[0029] 1. Weigh the Poria tablets, add 4 times the weight of the Poria tablets, and soak in ethanol with a concentration of 60v / v% for 12h;

[0030] 2. After soaking, reflux extraction for 2 hours to obtain ethanol reflux extract;

[0031] 3. Suction filtration of the ethanol reflux extract to obtain the filtrate;

[0032] 4. Concentrate the filtrate by flash evaporation to a relative density of 1.01-1.10, and recover ethanol;

[0033] 5. Spray-dry the obtained concentrated solution to obtain the total triterpene extract product of Poria cocos. Collect the dried extract, seal it, weigh it, and store it in a dry place.

[0034] After testing, the content of total triterpenoids in the prepared poria cocos total triterpene extract is 31.4wt% (calculated as pachymic acid), and the yield of dry paste is 1.18% (by weight).

Embodiment 2

[0036] A preparation method of Poria cocos total triterpene extract, the steps are as follows:

[0037] 1. Weigh the Poria tablets, add 6 times the weight of the Poria tablets, and soak in ethanol with a concentration of 70v / v% for 10h;

[0038] 2. After soaking, reflux extraction for 2 hours to obtain ethanol reflux extract;

[0039] 3. Suction filtration of the ethanol reflux extract to obtain the filtrate;

[0040] 4. Concentrate the filtrate by flash evaporation to a relative density of 1.01-1.10, and recover ethanol;

[0041] 5. Spray-dry the obtained concentrated solution to obtain the total triterpene extract product of Poria cocos. Collect the dried extract, seal it, weigh it, and store it in a dry place.

[0042] After testing, the total triterpene content of the obtained Poria cocos total triterpene extract is 38.2wt% (calculated by pachymic acid), and the dry paste yield is 1.7% (by weight).

Embodiment 3

[0044] A preparation method of Poria cocos total triterpene extract, the steps are as follows:

[0045] 1. Weigh the Poria tablets, add 8 times the weight of the Poria tablets, and soak in ethanol with a concentration of 70v / v% for 8h;

[0046] 2. After soaking, continuously reflux extraction for 2 times, the first time is 2 hours, the second time is 1 hour, and the two extracts are combined to obtain the ethanol reflux extract;

[0047] 3. Suction filtration of the ethanol reflux extract to obtain the filtrate;

[0048] 4. Concentrate the filtrate by flash evaporation to a relative density of 1.01-1.10, and recover ethanol;

[0049] 5. Spray-dry the obtained concentrated solution to obtain the total triterpene extract product of Poria cocos. Collect the dried extract, seal it, weigh it, and store it in a dry place.

[0050] After testing, the total triterpene content in the obtained Poria cocos total triterpene extract is 40 wt% (calculated by pachymic acid). The dry past...

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Abstract

The invention belongs to the technical field of extraction and purification of the effective parts of traditional Chinese medicines, and in particular discloses a preparation method of a total triterpene extract from poria cocos, comprising the following steps of: (1) weighing herbal pieces of poria cocos prepared for decoction, adding 60-80v / v% ethanol which is 4-8 times of the amount of the medicinal material and soaking for 3-12 hours, performing reflux extraction 1-3 times for 1-2 hours every time, combining the ethanol reflux extracting solutions; (2) performing suction filtration on theethanol reflux extracting solution to obtain filtrate; (3) concentrating the filtrate by flash evaporation till the relative density is 1.01-1.10, recovering the ethanol; and (4) spray drying the obtained concentrated solution to obtain the total triterpene extract product from poria cocos, collecting the dried extract, sealing, weighing and storing in a dry place. The method is simple, and the used solvent can be recycled, thus reducing the production cost and saving the energy source. The content of total triterpene in the extract prepared by the method is 31-58wt% counted by pachymic acid,and the extract has obvious anti-tumor and immunoregulation functions.

Description

technical field [0001] The invention relates to the technical field of extraction and purification of effective parts of traditional Chinese medicines, in particular to a preparation method of a total triterpene extract of Poria cocos. Background technique [0002] Poria cocos (Schw.) Wolf is a commonly used traditional Chinese medicine, which has been used for both medicine and food since ancient times. The history is recorded in "Shen Nong's Materia Medica", which is listed as top grade. It is the dry sclerotia of Polyporaceae fungus Poria cocos (Schw.) Wolf. Nature and flavor are sweet and light, flat, and belong to the Heart, Spleen and Lung Meridians. It has the functions of dispelling dampness and diuresis, invigorating the spleen and stomach, calming the mind and calming the nerves. It is clinically used to treat dysuria, edema and fullness, phlegm retention and cough, vomiting, diarrhea, spermatorrhea, stranguria, palpitations, forgetfulness, etc. The main compon...

Claims

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Application Information

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IPC IPC(8): A61K36/076A61P35/00A61P37/02
Inventor 张卫元刘焱文刘国庆王光忠叶晓川邓媛媛邵贝贝张永丹
Owner 武汉回盛生物科技股份有限公司
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