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Anti-depression drug and application thereof

An antidepressant, drug technology, applied in the field of medicine

Active Publication Date: 2019-04-23
山东肽莱生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still no studies and reports on the use of uninhibited terpenes for depression

Method used

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  • Anti-depression drug and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1 Unkissed terpene tablet for antidepressant

[0076] Untethered terpene 100g

[0077] Hypromellose 24g

[0078] Lactose 9g

[0079] Povidone K30 6g

[0080] Magnesium Stearate 10g

[0081] Talc powder 2.7g

[0082] (1) Weigh the prescribed amount of terpene, hypromellose and lactose and mix them evenly as a medicine powder;

[0083] (2) Weigh the prescribed amount of povidone K30 and add water to prepare a povidone K30 aqueous solution with a mass concentration of 3%, add the povidone K30 aqueous solution to the powder for wet granulation, pass the wet granules through a 20-mesh sieve, and dry at 60°C for 1.5 hours Sieve through a 20-mesh sieve;

[0084] (3) Add the prescribed amount of magnesium stearate and talcum powder to the granules obtained from the whole granulation, and compress them into 1000 tablets.

Embodiment 2

[0085] Example 2 Unbound terpene pachylic acid A compound tablet for antidepressant

[0086] Untethered Terpene 80g

[0087] Pachymic Acid A 40g

[0088] Hypromellose 24g

[0089] Lactose 9g

[0090] Povidone K30 7g

[0091] Magnesium Stearate 10g

[0092] Talc powder 3g

[0093] (1) Weigh the prescription amount of terpene, pachymic acid A, hypromellose and lactose and mix them uniformly as a medicinal powder;

[0094] (2) Weigh the prescribed amount of povidone K30 and add water to prepare a povidone K30 aqueous solution with a mass concentration of 3%, add the povidone K30 aqueous solution to the powder for wet granulation, pass the wet granules through a 20-mesh sieve, and dry at 60°C for 1.5 hours Sieve through a 20-mesh sieve;

[0095] (3) Add the prescribed amount of magnesium stearate and talcum powder to the granules obtained from the whole granulation, and compress them into 1000 tablets.

Embodiment 3

[0096] Example 3 Unbound terpene pachylic acid A compound tablet for antidepressant

[0097] Untethered Terpene 80g

[0098] Pachymic Acid A 20g

[0099] Hypromellose 24g

[0100] Lactose 9g

[0101] Povidone K30 6g

[0102] Magnesium Stearate 10g

[0103] Talc powder 2.7g

[0104] (1) Weigh the prescription amount of terpene, pachymic acid A, hypromellose and lactose and mix them uniformly as a medicinal powder;

[0105] (2) Weigh the prescribed amount of povidone K30 and add water to prepare a povidone K30 aqueous solution with a mass concentration of 3%, add the povidone K30 aqueous solution to the powder for wet granulation, pass the wet granules through a 20-mesh sieve, and dry at 60°C for 1.5 hours Sieve through a 20-mesh sieve;

[0106] (3) Add the prescribed amount of magnesium stearate and talcum powder to the granules obtained from the whole granulation, and compress them into 1000 tablets.

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Abstract

The invention belongs to the field of drugs, and particularly relates to an anti-depression drug and application thereof. The active ingredients of the anti-depression drug at least comprise friedelin, preferably, the active ingredients of the anti-depression drug include the friedelin and pachymic acid A. When the friedelin and the pachymic acid A are used as a composition, the weight part ratioof the the friedelin to the pachymic acid A in the anti-depression drug is (2-4):1. Oral tablets are preferably selected as the form of the anti-depression drug. The accessories of the oral tablets comprise hydroxypropyl methylcellulose, lactose, povidone K30, magnesium stearate and talcum powder. The drug has an improvement effect on the behavioral features, caused by chronic unpredictable mild stress, of a rat depression model.

Description

technical field [0001] The invention belongs to the field of drugs, and in particular relates to an antidepressant drug and its application. Background technique [0002] Depression is a mental disorder that seriously plagues human mental activities. Patients usually manifest as depressed mood, lack of interest in things, and suicidal tendencies. Accelerated pace of social life and excessive mental stress are considered to be social factors that induce depression. At least for now, the acceleration of the industrialization process is indeed accompanied by an increase in the incidence of depression. According to statistics, in the context of the global population, the lifetime prevalence rate of depression is as high as 5.2% to 16.2%, among which the incidence rate of women is particularly prominent. It is speculated that the prevalence of depression in mainland China may reach 7% to 8%, and the trend of younger people is obvious. According to the statistics and predictio...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K31/575A61P25/24
CPCA61K31/56A61K31/575A61P25/24A61K2300/00
Inventor 张凤田孙丽丽孙益虎
Owner 山东肽莱生物制药有限公司
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