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Application of trifolirhizin and antidepressant medicine

A clover bean pterosside and antidepressant technology, applied in the field of medicine, can solve problems such as side effects, achieve strong antidepressant effect and shorten immobility time.

Inactive Publication Date: 2020-05-29
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs can play a certain antidepressant effect, they will produce a series of side effects along with their drug effects; and a survey shows that about one-third of antidepressant patients are forced to stop taking the drug because they cannot tolerate the side effects of the drug

Method used

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  • Application of trifolirhizin and antidepressant medicine
  • Application of trifolirhizin and antidepressant medicine
  • Application of trifolirhizin and antidepressant medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Embodiment 1 of the present invention discloses a kind of preparation method of antidepressant medicine, specifically comprises the following steps:

[0036] (1) Weigh 10g pteroside, 2g microcrystalline cellulose, 5g sodium carboxymethylcellulose, 1.5g crospovidone and 20g pregelatinized starch, and set aside;

[0037] (2) Pass the 80-mesh sieve after the raw material is pulverized, fully mix, and add the ethanol that concentration is 60% twice, adopt wet granulation;

[0038] (3) Dry the prepared granules, and the dried granules are sized and blended, and then compressed into tablets to obtain Pterophyllin tablets.

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Abstract

The invention discloses an application of trifolirhizin to preparation of medicines for preventing or treating depression. The trifolirhizin is a flavonoid compound extracted from sophora alopecuroides, is safe and non-toxic in sources, has the effect of resisting depression, can be used for preparing antidepressant medicines, does not produce side effects and is safe and efficient. Besides, the invention also provides an antidepressant medicine. The antidepressant medicine comprises the trifolirhizin and a carrier acceptable for medicines.

Description

technical field [0001] The invention relates to the technical field of medicine, and more specifically relates to the application of pterostaloside and an antidepressant drug. Background technique [0002] Depression is one of the most common mental illnesses. It is characterized by significant and persistent depression, often accompanied by serious psychological and physical disorders, and is extremely harmful to human health. The world invests a lot in its research and development every year, bringing great benefits to the society. serious burden on the family. In addition, patients with depression are often accompanied by changes in eating patterns related to insomnia, lethargy, overeating, weight loss or anorexia, and more serious symptoms include some extreme symptoms such as circadian rhythm and endocrine disorders. At present, there are at least 90 million depression patients in my country, and only 5% of them have received treatment; at the same time, among the suic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/20A61P25/24
CPCA61K31/7048A61K9/2059A61P25/24
Inventor 王汉卿陶伟伟苟军丽肖东刘颖赵建军雍婧姣王庆贺凯张霞冯军王建寰高晓娟付慧玲柳全霞曾亮杨彩艳
Owner NINGXIA MEDICAL UNIV
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