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Ginkgo biloba leaf total terpene lactone extract, and its preparing method, medicinal composition and use

The technology of ginkgolide and ginkgo biloba is applied in the fields of phytochemistry and medicinal chemistry, which can solve the problems of experimental depression that has not yet been seen against animals, and that patients have not received adequate treatment, and achieves high safety, small side effects, and effective doses. low effect

Inactive Publication Date: 2007-06-13
ZHEJIANG HISUN PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Mental depression ranks fifth among the top ten diseases in the world, and it is expected to jump to the second place by 2020. According to WHO figures, there are currently 85 million depressed patients in the world. It is estimated that by 2005, the number of depressed patients will The incidence rate will reach 10% of the total population; and there are 10-20 million people who have suicidal thoughts every year. Although the severity of depression is so great, these patients are not adequately treated, only 53% of the patients Less than 10% of patients with depression who have been treated with drugs have received appropriate drug treatment
However, ginkgolide has not yet seen anti-depressive research in animal experiments

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Preparation of Ginkgo biloba total lactone extract of the present invention

[0027] Get 2 kg of Ginkgo biloba coarse powder, add 20 liters of 60% ethanol, heat to reflux, extract 2 times, each time for 3 hours, reclaim ethanol, go up DM-130 macroporous adsorption resin (Shandong Lukang Pharmaceutical Co., Ltd. resin branch factory production) Column, eluted with 60% ethanol, collected the ethanol eluate, recovered ethanol, put it on a polyamide column (column chromatography, produced by Shanghai Chemical Reagent Company), eluted with water, collected the water eluate, concentrated under reduced pressure to an appropriate amount, and used Extract with ethyl acetate, recover the solvent, and dry under vacuum at 80°C to obtain 3.8 g of total lactones from Ginkgo biloba, with a total lactone content of 83.38%. The content of each lactone in the total lactone, the content of GJ is 3.62%, the content of GC is 12.70%, the content of BB is 49.59%, the content of ...

Embodiment 2

[0028] Embodiment 2: Preparation of Ginkgo biloba total lactone extract of the present invention

[0029] Get 2 kg of Ginkgo biloba coarse powder, add 24 liters of acetone and heat to reflux, extract 2 times, each 2 hours, reclaim acetone, go up DM-130 macroporous adsorption resin (Shandong Lukang Pharmaceutical Co., Ltd. Resin Branch Factory production) column, 60 % ethanol for elution, collect the ethanol eluate, reclaim ethanol, put it on a polyamide column (column chromatography, produced by Shanghai Chemical Reagent Company), wash it with water, collect the water eluate, concentrate under reduced pressure to an appropriate amount, and wash with ethyl acetate Extract, recover the solvent, and dry in vacuum at 80°C to obtain 3.95 g of total lactones from Ginkgo biloba, with a total lactone content of 85.11%. The content of each lactone in the total lactone, wherein the content of GJ is 7.37%, the content of GC is 14.94%, the content of BB is 47.84%, the content of GA is 24....

Embodiment 3

[0030] Embodiment 3: the preparation of Ginkgo biloba total lactone extract of the present invention

[0031] Get 2 kg of ginkgo leaf coarse powder, add 24 liters of acetone and heat to reflux, extract twice, each time for 2 hours, recycle acetone, put on D101 macroporous adsorption resin (produced by Tianjin Pesticide Factory) column, wash with 70% ethanol, collect ethanol for elution solution, recovered ethanol, put it on a polyamide column (column chromatography, produced by Shanghai Chemical Reagent Company), eluted with water, collected the water eluate, concentrated under reduced pressure to an appropriate amount, extracted with ethyl acetate, recovered the solvent, and dried in vacuum at 80°C , to obtain 4.87g of ginkgo biloba total lactones, with a total lactone content of 71.76%. The content of each lactone in the total lactone, wherein the content of GJ is 9.41%, the content of GC is 20.22%, the content of BB is 40.58%, the content of GA is 24.65%, and the content of...

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PUM

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Abstract

The present invention relates to a new-type high-effective safety medicine-ginkgo leaf total lactone for curing depression. It is a terpene lactone extracted from ginkgo biloba. L or other portions of said plant, such as ginkgo nut, ginkgo root bark and ginkgo twing, in which five terpene lactone compounds of bilobalide A, bilobalide B, bilobalide C, bilobalide J and bilobalide are mainly contained.

Description

technical field [0001] The present invention relates to the fields of phytochemistry, medicinal chemistry and the like, in particular, the present invention relates to total lactone extract of ginkgo biloba and its preparation method and application. Background technique [0002] Mental depression ranks fifth among the top ten diseases in the world, and it is expected to jump to the second place by 2020. According to WHO figures, there are currently 85 million depressed patients in the world. It is estimated that by 2005, the number of depressed patients will The incidence rate will reach 10% of the total population; and there are 10-20 million people who have suicidal thoughts every year. Although the severity of depression is so great, these patients are not adequately treated, only 53% of the patients Less than 10% of patients with depression who have been treated with drugs have received appropriate drug therapy. Fluoxetine, sertraline, paroxetine, etc. are SSRI drugs, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K9/16A61K9/20A61K9/48A61P25/24
Inventor 杨义芳
Owner ZHEJIANG HISUN PHARMA CO LTD
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