Pharmaceutical composition of chlorambucil and medical application of pharmaceutical composition to anti-depression
A technology of chlorambucil and its composition, which is applied in the field of biomedicine, can solve the problems that there are no related reports on chlorambucil and its pharmaceutical composition, and achieve outstanding substantive features, improved antidepressant effect, Significantly improved effect
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Embodiment 1
[0017] Example 1: Compound (I) Separation Preparation and Structure Confirmation
[0018] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.
[0019] Separation method: (a) Grind the dried tuber root (2kg) of Pseudostellariae Pseudostellariae, extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until there is no alcohol smell (3L), and then use petroleum ether (3L ×3 times), ethyl acetate (3L×3 times) and water-saturated n-butanol (3L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) In the step (a), the n-butanol extract is removed with a D101 type macroporous resin, and first eluted with 10% ethanol for 8 column volumes, then with 70% ethanol for 1...
Embodiment 2
[0022] Embodiment 2: antidepressant effect
[0023] 1. Materials and methods
[0024] 1.1 Animals
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