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New composition of salvia miltiorrhiza and derivative, preparation method and medicine application thereof

A technology of compounds and derivatives, applied in the field of medicine

Inactive Publication Date: 2009-09-23
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, Danshen or its components have not been used to fight cancer and treat mental illness

Method used

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  • New composition of salvia miltiorrhiza and derivative, preparation method and medicine application thereof
  • New composition of salvia miltiorrhiza and derivative, preparation method and medicine application thereof
  • New composition of salvia miltiorrhiza and derivative, preparation method and medicine application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment 1: pharmacodynamic experiment:

[0077] (1) Anti-senile dementia activity research

[0078] Antimicroglial activation drug screening.

[0079] The chronic inflammatory response mediated by the activation of microglia is an important link in the occurrence and development of neurodegenerative diseases. Inhibiting the activation of microglia may become a new target for drug discovery. LPS activates microglia to release NO, pro-inflammatory cytokines and reactive oxygen species. In this experiment, a screening platform for the abnormal activation of N9 microglia activated by LPS in vitro was established, and the release of NO from activated microglia was used as an index to screen the compounds with inhibitory effect on microglia activation among the three extracted and separated compounds.

[0080] Experimental Materials:

[0081] (1) Cells: N9 microglial cells

[0082] (2) Reagents: Fetal bovine serum (Gibco BRL, Grand Island, USA); IMDM medium (Gibco BRL,...

Embodiment 2

[0139] Structure analysis:

[0140] Compound (1) yellow powder (methanol), [α] D 20 20.4 (c=0.260, MEOH), the high-resolution mass spectrum gives the quasi-molecular ion peak m / z 319.0575[M+Na] + (calculated value is 319.0577), determine that molecular formula is C 17 h 12 o 5 . IR (KBr) spectrum 3425cm -1 Showing hydroxyl absorption, 1746cm -1 Showing lactone absorption, 1602, 1571cm -1 Shows benzene ring absorption. According to 1H-NMR (MeOH, 300Hz) and HMQC spectrum, a methyl hydrogen signal signal δ: 0.98 (3H, d, 7.2, δ C 22.8); a SP3 hybridized methine hydrogen signal δ: 4.96 (1H, q, 7.2, δ c 35.9); two adjacent hydrogen signals on two groups of benzene rings δ H : 6.67 (d, 1H, J=8.4, δ c 113.6) and δ H : 7.06(d, 1H, J=8.4, δ c 129.4), δ H 6.79 (d, 1H, J=8.4, δ c 124.4) and δ H 6.75 (d, 1H, J=8.4, δ c 120.2); and a hydrogen signal on a double bond δ H 7.66(s, 1H, δ c 141.4). 13 C-NMR (MeOH, 75Hz) gave 17 carbon signals, including two saturated ...

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PUM

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Abstract

The invention relates to a new composition of salvia miltiorrhiza and a derivative, a preparation method and application thereof, belonging to the technical field of medicine, wherein the three compositions are salvia miltiorrhiza new lactone A, salvia miltiorrhiza new lactone B and salvia miltiorrhiza new lactone C and derivative thereof and effective parts, which have a (1) chemical structure general formula. The invention also relates to application of a new skeleton composition and a derivative and an effective part thereof on preparing medicine, in particular to the application of same on preparing spiritual class medicine and anticancer class medicine, wherein R1 is selected from hydrogen, alkyl, undersaturated alkyl, hydroxide radical, alkoxyl, carboxyl, esterifiable carboxyl, balmy substituent, halogen, and the like, R2, R3 and R4 are selected from hydrogen, alkyl, undersaturated alkyl, balmy substituent, low grade sugar indican, polysaccharide indican, metallic ions and organic acid ester group, and the R2, the R3 and the R4 can be same and also can be different.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a new compound in salvia miltiorrhiza and derivatives thereof, a preparation method and a medical application thereof. Background technique [0002] Salvia miltiorrhiza Bge. is one of the medicines widely used in traditional Chinese medicine. As a drug for the treatment of cardiovascular diseases, it has a broad basis of medication and significant curative effect, and has a long history of clinical application. Modern medical research and clinical practice have shown that Danshen has the effect of dilating coronary arteries, increasing coronary blood flow, slowing heart rate, and improving myocardial hypoxia. It is often used to treat coronary heart disease, angina pectoris, chest tightness, and palpitations. It can treat myocardial infarction and myocarditis, and can improve acute symptoms and ischemic changes in ECG. Salvia miltiorrhiza can inhibit platelet aggregation, inhibi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/93A61K31/365A61P25/00A61P35/00A61P25/28A61P25/24
Inventor 宋少江彭缨梁啸姜珍马志强
Owner SHENYANG PHARMA UNIVERSITY
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