65 results about "Ginkgolide C" patented technology

The invention provides a gingko-buckthorn tea beverage, which is prepared by lotus leaf, hawkthorn, buckthorn extract, gingko leaf extract, black tea, pu'er tea and water. According to the ginkgolides A (C20H24O9), B (C20H24910) and C (C20H24O11) and bilobalide (C15H18O8), the content of the gingko leaf in the gingko-buckthorn tea is not less than 4.0mg; according to Isorhamnetin (C16H12O7), the content of the buckthorn and the gingko leaf is not less than 0.025mg; according to anhydrous rutin, the content of total flavonoid is not less than 0.13g. The invention also discloses a preparation method for the gingko-buckthorn tea beverage. The gingko-buckthorn tea beverage of the invention has the functions of blood-activating, stasis-dissolving, blood pressure decreasing and blood lipid decreasing, which is applicable for the prevention and health care of middle-aged and aged people, people with high blood lipid and high blood pressure and fat people.

The invention relates to the field of plant extraction and in particular relates to a method for detecting bilobalide injection for treating cardiovascular and cerebrovascular diseases and a method for determining content of active ingredients. The content of ginkgo terpene lactone in every 1ml of the determined bilobalide injection is 1-10mg / ml based on the total amount of bilobalide (C15H18O8), ginkgolides A (C20H24O9), ginkgolides B (C20H24O10) and ginkgolides C (C20H24O11), and preferably 4.25-5.75mg.

The subject invention provides ginkgolide C derivatives compounds having the structure: wherein R is H or -A-Ar, where A is an alkyl group; and Ar is an aryl group, which may contain heteroatoms and may be unsubstituted or substituted by one to five substituents each selected from the group consisting of hydrogen, alkoxy, —CH2CO2R4, and —CH2CONR5R6; where R4 is an alkyl group; and R5 and R6 are each, independently, hydrogen or a branched or unbranched alkyl group; wherein R1 is H or —COR7, where R7 is alkyl, aryl or amino; wherein R2 is present or absent, and when present is H, —COR8 or —CO-Z-R8; where R8 is alkyl, aryl or amino; and Z is oxygen; wherein R3 is present or absent, and when present is —COR9; where R9 is alkyl or aryl; wherein only one of R2 or R3 is present in the compound; wherein only two of R, R1, R2 and R3 are H; and wherein each of a and b designates a single covalent bond which is present or absent, where bond a is present when R3 is absent and bond b is present when R2 is absent; or an optically pure enantiomer of the compound. Additionally, the subject invention provides methods of inhibiting the activity of a glycine receptor using these compounds.

The present invention discloses a compound yinlingtong capsule quality detection method, which provides thin-layer identification on ganoderma lucidum, radix scrophulariae and acorus tatarinowii, wherein a high-performance liquid chromatography method is used to carry out content determination on ginkgolide A, ginkgolide B, ginkgolide C and bilobalide. According to the present invention, when the quality control method is used to carry out separation detection, advantages of interference factor resisting, high detection efficiency, good stability, rapid analysis and short detection period can be provided; and the method is the reliable compound yinlingtong capsule control method, and establishes the accurate and feasible control standard for the compound yinlingtong capsule quality detection.

The invention provides a method for detecting ginkgolide effective parts, relates to the field of plant extraction, particularly relates to a method for extracting and separating ginkgolide, and based on the extraction and separation method, the ginkgolide with unchanged components is obtained. The ginkgolide with fixed components is obtained by the steps of extraction, leaching, column chromatographic separation, crystallization and crystal mixing and contains 25.0-50.0 percent of bilobalide (C15H18O8), 20.0-45.0 percent of ginkgolide A (C20H24O9), 10.0-30.0 percent of ginkgolide B (C20H24O10) and 5.0-15.0 percent of ginkgolide C (C20H24O11), and the total amount of the bilobalide, the ginkgolide A, the ginkgolide B and the ginkgolide C is more than 95 percent.

The invention discloses application of ginkgo leaf total lactones in preparation of a medicament for preventing or treating deafness and tinnitus. The ginkgo leaf total lactones are extracted from ginkgo leaves, the lactone component content is 50 to 99 percent by HPLC (High Performance Liquid Chromatography) detection, and the ginkgo leaf total lactones mainly comprise four chemical components, namely ginkgo lactone A, ginkgo lactone B, ginkgo lactone C and ginkgo seed lactone. The inventor performs experiments of the ginkgo leaf total lactones on a rat audition effect, and the results show that the ginkgo leaf total lactones have certain protection effect on the rat audition, the effect of the ginkgo leaf total lactones is obviously superior to that of ginkgo leaf extract and a quantitative effect relationship is formed. Therefore, the ginkgo leaf total lactones can be used for preparing the medicament for preventing or treating the deafness and the tinnitus. The medicament is a medicinal composition prepared from the ginkgo leaf total lactones and medicinal auxiliary materials according to a conventional method. The medicament can be prepared into oral preparations such as tablets, capsules and the like, can also be prepared into injection preparations such as injection, freeze-dried powder and the like, and can further be prepared into patches and the like.

The invention relates to the field of medicine, in particular to application of one or more ginkgo terpene lactone compounds or pharmacologically acceptable salts, esters, hydrates, solvates and isomers of the ginkgo terpene lactone compounds or any crystal forms, racemic mixtures and metabolites of the ginkgo terpene lactone compounds or a mixture of the ginkgo terpene lactone compounds being used as effective components to preparation of drugs and health care products for preventing and / or treating tremor. The problem of the lack of the drugs for preventing and / or treating the tremor in an existing medicine field is solved. The ginkgo terpene lactone compounds and compositions both obviously improve the state of an illness of an essential tremor model mouse, and the improvement action ofa ginkgo terpene lactone B and bilobalide composition and a bilobalide A, bilobalide B and bilobalide C composition on the essential tremor model mouse is close to that of a positive drug propranololhydrochloride. The state of the illness of essential tremor patients and vascular tremor patients is obviously improved, and no adverse reaction is found in clinical observation cases.

The subject invention provides ginkgolide C derivatives compounds having the structure:wherein R is H or -A-Ar,where A is an alkyl group; andAr is an aryl group, which may contain heteroatoms and may be unsubstituted or substituted by one to five substituents each selected from the group consisting of hydrogen, alkoxy, —CH2CO2R4, and —CH2CONR5R6;where R4 is an alkyl group; andR5 and R6 are each, independently, hydrogen or a branched or unbranched alkyl group;wherein R1 is H or —COR7,where R7 is alkyl, aryl or amino;wherein R2 is present or absent, and when present is H, —COR8 or —CO—Z—R8;where R8 is alkyl, aryl or amino; andZ is oxygen;wherein R3 is present or absent, and when present is —COR9;where R9 is alkyl or aryl;wherein only one of R2 or R3 is present in the compound;wherein only two of R, R1, R2 and R3 are H; andwherein each of a and b designates a single covalent bond which is present or absent,where bond a is present when R3 is absent and bond b is present when R2 is absent;or an optically pure enantiomer of the compound. Additionally, the subject invention provides methods of inhibiting the activity of a glycine receptor using these compounds.

The invention relates to a content determination method of gingko diterpene lactone for injection, especially a method for simultaneous determination of the content of ginkgolide A, ginkgolide B, ginkgolide C and ginkgolide K in ginkgolide for injection by HPLC-ELSD technique. The method adopts a C18 chromatographic column, takes tetrahydrofuran-water-methanol (n-propanol) as the mobile phase, and determines the lactone content by means of gradient elution. The technology provided by the invention is simple, fast and accurate, and provides certain scientific basis for quality control of the gingko diterpene lactone for injection.

The invention relates to a cosmetic product effect additive, and particularly provides an anti-aging ginkgo leaf composition, which contains, by weight, 50-95 parts of ginkgo leaf total lactone, 22-60parts of ginkgo leaf total flavone, and less than 0.0035 part of ginkgo leaf ginkgolic acid, wherein the ginkgo leaf total lactone is one or a plurality of materials selected from ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J and bilobalide, and the ginkgo leaf total flavone is one or a plurality of materials selected from rutin, quercetin-3-O-glucoside, kaempferol-3-O-glucoside, isorhamnetin-3-O-glucoside and myricetin. According to the present invention, the composition can be obtained by mixing the monomers, and can further be obtained by extracting, separating and purifying ginkgo leaves; the effective components in the ginkgo leaves can be effectively enriched through the multi-stage purification with different resins so as to significantly improve the cell aging delaying effect of the composition; and the anti-aging ginkgo leaf composition can be widely used in various cosmetics.