31 results about "Halcinonide" patented technology

The present invention provides a preparation method of halcinide, comprising: 1) chlorination reaction: in SO 2 In the presence of, compound 1 reacts with a chlorinating reagent selected from the group consisting of acetyl chloride, propionyl chloride, benzoyl chloride, lithium chloride, carbon tetrachloride, chlorosuccinimide, dichloride One or more of hydantoin; 2) ring-opening reaction: compound 2 reacts with hydrogen fluoride to obtain hacinide. The beneficial effects of the invention are that the reaction conditions are mild, the environment is friendly, the operation is easy, the cost is low, and it has industrial value, can effectively control side reactions, and improve the reaction yield and quality; no high-risk reactions are involved in the process design, and it is easy to realize industrialization; There is a high pollution reaction, which reduces the pressure of environmental protection treatment.

The invention provides an application of a biomarker in the preparation of children's precocious puberty screening and diagnosis products; the biomarker includes halcinonide, corticosterone, cortisone, 11-deoxycorticosterone, 11-deoxycortisol , 17α‑hydroxyprogesterone, betasone butyrate, fludrocortisone acetate, methylprednisolone acetate, prednisolone acetate, hydrocortisone valerate, methyltestosterone, One or more of androstenediones. The present invention measures a plurality of children's samples, and the results show that specific compounds have significant differences between healthy children and precocious puberty children, and the P value of T test is less than 0.1, indicating that the contents of these compounds have significant differences. Therefore, these compounds with significant differences can be used as diagnostic markers for early screening and diagnosis of precocious puberty in children.

The invention discloses a method for the quantitative detection of halcinonide in cosmetics, which comprises the steps that: 1) halcinonide and butenolide II are added into chromatographic methanol to obtain a reference substance; 2) a butenolide II methanol solution is added into a centrifuge tube and then cosmetics to be detected are added into the centrifuge tube which is dried in a manner of blow; 3) an extraction reagent is added; 4) centrifugation is carried out to obtain all organic phase solutes; 5) the organic phase solutes are dissolved in a mobile phase and a liquid layer is obtained after centrifugation; 6) the reference substance obtained by the step 1) and the liquid layer by the step 5) are carried out high efficiency liquid chromatographic analysis respectively; 7) the content of halcinonide in cosmetics to be detected is equal to the absorption peak area ratio of the halcinonide and the butenolide II in the liquid layer which is multiplied by the concentration of the halcinonide in the reference substance and divided by the absorption peak area ratio of the halcinonide and the butenolide II in the reference substance. The method for halcinonide detection provided by the invention has the advantage of high accuracy.

Halcinonide cream is provided. The halcinonide cream comprises halcinonide adopted as the active component, solid in oil-phase components, a consistency modifier, a humectant, an emulsifier, an aseptic and water, and is characterized by also comprising edetate calcium disodium.

The invention discloses an ointment for treating gynaopathy and dermatoses and a preparation method thereof. The externally-applied ointment is prepared from halcinonide preparation, menthol crystal and camphor which are utilized as raw materials according to a certain preparation technology, and is prepared from the following raw materials in parts by weight: 6 to 6.5 parts of halcinonide preparation, 15 to 20 parts of menthol crystal, 15 to 20 parts of camphor, 3 to 3.5 parts of edetate disodium, 20 to 40 parts of polyethylene glycol mono stearate, 0 to 3 parts of essence, 0 to 2 parts of carbomer, 0 to 2 parts of sodium bicarbonate and 15 to 25 parts of pure water. The externally-applied ointment is low in cost, has the effects of clearing away heat, eliminating dampness, dispelling the wind, killing worms, diminishing inflammation and relieving itching, has better treatment effects, has the characteristics of being easy to prepare, lower in cost and obvious in treatment effect, and can be used for treating the gynaopathy, such as vaginitis, cervicitis and cervical erosion, caused by various germs, and treating the dermatoses, such as tinea corporis, tinea cruris, tinea of feetand hands and various dermatitis, caused by various fungus infection. The externally-applied ointment has exact treatment effects, takes effect rapidly, is low in cost and convenient to use, and has no toxic and side effects, thus being worthy of popularization and application.

The invention relates to the technical field of medicine, in particular to the application of halcinonide and its derivatives in the preparation of medicines for treating and / or preventing cerebrovascular diseases. The halcinonide and its derivatives described in the present invention have the general structural formula shown in formula (I), and their therapeutic effect on ischemic stroke is evaluated by MCAO cerebral ischemia-reperfusion injury animal model. The experimental results show that halcinonide and its derivatives prednisone and testosterone propionate can significantly improve the animal neurological deficit score, reduce the size of the infarct, can be used to treat ischemic stroke, and has a good clinical effect. Application prospects.